A5047575707- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Advanced X-ray and CT Imaging
- Hepatitis C virus research
- Bone fractures and treatments
- Cardiac Arrhythmias and Treatments
- Antifungal resistance and susceptibility
- Ultrasound in Clinical Applications
- Liver Diseases and Immunity
- Diversity and Career in Medicine
- Organ Transplantation Techniques and Outcomes
- Medical Imaging Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Statistical Methods in Clinical Trials
- Radiation Dose and Imaging
- Elbow and Forearm Trauma Treatment
- Immune Cell Function and Interaction
- Hip and Femur Fractures
- Pneumonia and Respiratory Infections
- Fungal Infections and Studies
- Autoimmune and Inflammatory Disorders Research
- Lysosomal Storage Disorders Research
Universität Hamburg
2018-2025
University Medical Center Hamburg-Eppendorf
2018-2025
Zimmer Biomet (Germany)
2021-2024
Eppendorf (Belgium)
2024
Heidelberg University
2017-2020
Charité - Universitätsmedizin Berlin
2019-2020
Helios Hospital Schwerin
2019-2020
Stiftung Institut für Herzinfarktforschung
2019-2020
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2018-2019
University Hospital Heidelberg
2017-2018
Device-detected atrial high-rate episodes (AHREs) are arrhythmias detected by implanted cardiac devices. AHREs resemble fibrillation but rare and brief. Whether the occurrence of in patients without (as documented on a conventional electrocardiogram [ECG]) justifies initiation anticoagulants is not known. Download PDF Research Summary. We conducted an event-driven, double-blind, double-dummy, randomized trial involving 65 years age or older who had lasting for at least 6 minutes one...
Even on optimal therapy, many patients with heart failure and atrial fibrillation experience cardiovascular complications. Additional treatments are needed to reduce these events, especially in preserved left ventricular ejection fraction.This prespecified subanalysis of the randomized EAST-AFNET4 trial (Early Treatment Atrial Fibrillation for Stroke Prevention Trial) assessed effect systematic, early rhythm control therapy (ERC; using antiarrhythmic drugs or catheter ablation) compared...
•This is the largest cohort of patients with autoimmune hepatitis and laboratory proven SARS-COV-2 infection reported to date.•There were no differences in rates major adverse COVID-19 outcomes between AIH those other liver diseases.•Patients had higher hospitalization than without disease, but increased risk ICU admission or death.•Independent factors for death age baseline disease severity, not use immunosuppression. Background & AimsSevere acute respiratory syndrome coronavirus 2...
Implant survival and implant success (freedom of biologic complications) are important factors in assessing the therapy. However, these not only determinants. Patients' satisfaction also plays a very role daily practice. Therefore, aim this study was to assess patients' regarding function (phonetics, chewing comfort, stability, cleanability) aesthetics patients treated with XiVE Frialite implants private periodontal practice ten years after placement. Furthermore, oral health-related quality...
Abstract Background and Aims Patients with long atrial high-rate episodes (AHREs) ≥24 h stroke risk factors are often treated anticoagulation for prevention. Anticoagulation has never been compared no in these patients. Methods This secondary pre-specified analysis of the Non-vitamin K antagonist Oral anticoagulants patients Atrial High-rate (NOAH-AFNET 6) trial examined interactions between AHRE duration at baseline edoxaban placebo factors. The primary efficacy outcome was a composite...
Objective The objective of this prospective study was to evaluate whether magnetic resonance imaging (MRI) is equivalent lateral cephalometric radiographs (LCR, "gold standard") in analysis. Methods applied MRI technique optimized for short scanning time, high resolution, contrast and geometric accuracy. Prior orthodontic treatment, 20 patients (mean age ± SD, 13.95 years 5.34) received LCR. datasets were postprocessed into cephalograms. Cephalometric analysis performed twice by two...
Many clinical trials focus on the comparison of treatment effect between two or more groups concerning a rarely occurring event. In this situation, showing relevant with an acceptable power requires observation large number patients over long period time. For feasibility issues, it is therefore often considered to include several event types interest, non-fatal fatal, and combine them within composite endpoint. Commonly, endpoint analyzed standard survival analysis techniques by assessing...
Despite advances in the management of bloodstream infections (BSI) caused by Candida spp., mortality still remains high critically ill patients. The worldwide epidemiology yeast-related BSI is subject to changing species distribution and resistance patterns, challenging antifungal treatment strategies. aim this single-center study was identify predictors after 28 180 days a cohort mixed surgical medical patients with candidemia.Patients, who had been treated for laboratory-confirmed spp. one...
Short and rare episodes of atrial fibrillation (AF) are commonly detected using implanted devices (device-detected AF) in patients with prior stroke or transient ischemic attack (TIA). The effectiveness safety oral anticoagulation TIA device-detected AF but no ECG-documented is unclear.
ABSTRACT Background Obtaining non‐directed samples from the upper bronchial tree is easier to perform and poses fewer risks for critically ill patients than deep bronchoalveolar lavage (BAL). Since invasive pulmonary aspergillosis associated with a high mortality in patients, timely diagnosis rapid initiation of treatment are utmost importance. Objectives The objective this study was compare Galactomannan (GM) testing by Enzyme Immunoassay (EIA), GM Lateral Flow Assay (LFA) detection...
Objectives Fat quantification by dual-energy computed tomography (DECT) provides contrast-independent objective results, for example, on hepatic steatosis or muscle quality as parameters of prognostic relevance. To date, fat has only been developed and used source-based DECT techniques fast kVp-switching CT dual-source CT, which require a prospective selection the imaging mode. It was purpose this study to develop material decomposition algorithm in phantoms validate it vivo patient liver...
Refractory ascites is the main reason for implantation of a transjugular intrahepatic portosystemic shunt (TIPS) in liver cirrhosis, but control by TIPS fails relevant proportion cases. Here, we investigated whether routine parameters pre-TIPS can predict persistent after and predicts long-term clinical outcome.A detailed retrospective analysis 128 patients receiving expanded polytetrafluoroethylene-covered stents treatment refractory was performed. Persistent post-TIPS defined as prolonged...
Transnasal videoendoscopy (TVE) is the standard of care when staging pharyngolaryngeal lesions. This prospective study determined if preoperative TVE improves prediction difficult videolaryngoscopic intubation in adults with expected airway management addition to Simplified Airway Risk Index (SARI).374 anesthetics were included (252 TVE). The primary outcome was a alert issued by anesthetist after Macintosh videolaryngoscopy. SARI, clinical factors (dysphagia, dysphonia, cough, stridor, sex,...
Cirrhosis is associated with an increased surgical morbidity and mortality. Portal hypertension the surgery type have been established as critical determinants of postoperative outcome. We aim to evaluate hypothesis that preoperative transjugular intrahepatic portosystemic shunt (TIPS) placement in patients cirrhosis a lower incidence in-house mortality/liver transplantation (LT) after surgery.A retrospective database search for years 2010-2020 was carried out. identified 64 who underwent...
Liver stiffness (LS) as measured by transient elastography is increasingly used to noninvasively assess liver fibrosis. However, LS efficiently modulated confounders like arterial and portal pressure (PP). We here study the effect of acute hemodynamic changes on (measured µFibroscan) in a rodent model cirrhosis response pharmacological modulation PP losartan, nitric oxide donors, propranolol. Additionally, hepatic venous gradient (HVPG) under propranolol therapy were assessed with regard...
In medical studies with recurrent event data a total time scale perspective is often needed to adequately reflect disease mechanisms. This means that the hazard process defined on since some starting point, e.g. beginning of disease, in contrast gap where restarts after each event. While techniques such as Andersen-Gill model have been developed for analyzing from perspective, simulation data, sample size planning, not investigated so far.We derived algorithm covering can be used planning...
Abstract Objective To analyze changes in the muscular fat fraction (FF) during immobilization at intensive care unit (ICU) using dual-energy CT (DECT) and evaluate predictive value of DECT FF as a new imaging biomarker for morbidity survival. Methods Immobilized ICU patients ( n = 81, 43.2% female, 60.3 ± 12.7 years) were included, who received two dual-source scans (CT1, CT2) within minimum interval 10 days between 11/2019 09/2022. The was quantified posterior paraspinal muscle by...
Background Re-treatment in patients with a chronic hepatitis C virus (HCV) infection and previous failure to direct-acting antiviral (DAA) treatment remains challenge. Therefore, we investigated the success rate of re-treatment regimens used at our center from October 2011 March 2018. Methods A retrospective analysis DAA-based HCV therapies 1096 was conducted. Factors associated virological relapse were identified by univariable multivariable logistic regression, evaluated an sustained...