A5075542081- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Metabolism and Genetic Disorders
- Pulmonary Hypertension Research and Treatments
- Hormonal Regulation and Hypertension
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Porphyrin Metabolism and Disorders
- Adrenal and Paraganglionic Tumors
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Neurological disorders and treatments
- Biochemical and Molecular Research
- Genomic variations and chromosomal abnormalities
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Non-Invasive Vital Sign Monitoring
- Skin and Cellular Biology Research
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
Institute of Clinical and Experimental Medicine
2015-2024
Charles University
2014-2024
General University Hospital in Prague
2005-2024
Electrophysiology and Heart Modeling Institute
2024
Centre de Recherche Cardio-Thoracique de Bordeaux
2024
Hôpital Rangueil
2024
AZ Sint-Jan
2024
Na Homolce Hospital
2013-2024
Medical University of Graz
2024
Inserm
2024
Pulmonary vein isolation is the most prevalent approach for catheter ablation of paroxysmal atrial fibrillation. Long-term success procedure diminished by arrhythmia recurrences occurring predominantly because reconnections in previously isolated pulmonary veins. The aim EFFICAS I multicenter study was to demonstrate correlation between contact force (CF) parameters during initial and incidence gaps (gap) at 3-month follow-up.A radiofrequency with integrated CF sensor (TactiCath, Endosense,...
A challenge of pulmonary vein isolation (PVI) in catheter ablation for paroxysmal atrial fibrillation (PAF) is electrical reconnection the PV. EFFICAS I showed correlation between contact force (CF) parameters and PV durable but no prospective evaluation was made. II a multicentre study to prospectively assess impact CF guidance an effective reduction PVI gaps. Pulmonary using radiofrequency (RF) with integrated sensor (TactiCath™) performed patients PAF. Operators were provided I-based...
Device-detected atrial high-rate episodes (AHREs) are arrhythmias detected by implanted cardiac devices. AHREs resemble fibrillation but rare and brief. Whether the occurrence of in patients without (as documented on a conventional electrocardiogram [ECG]) justifies initiation anticoagulants is not known. Download PDF Research Summary. We conducted an event-driven, double-blind, double-dummy, randomized trial involving 65 years age or older who had lasting for at least 6 minutes one...
The Atrial Fibrillation Ablation Pilot Study is a prospective registry designed to describe the clinical epidemiology of patients undergoing an atrial fibrillation (AFib) ablation, and diagnostic/therapeutic processes applied across Europe. aims 1-year follow-up were analyse how centres assess in routine practice success procedure evaluate rate long-term safety/complications.Seventy-two 10 European countries asked enrol 20 consecutive first AFib ablation procedure. A web-based case report...
Observational studies and a recent randomized controlled trial have provided some evidence that cardioneuroablation (CNA) may prevent syncope recurrence in patients affected by cardioinhibitory reflex during the first 2 years following procedure. Nevertheless, many issues concerning clinical indications, methodology, long-term results remain unresolved. These constitute background of this manuscript which pioneers CNA experts debated critical aspects aimed at finding agreement or, if not...
The aim of our study was to assess the prevalence pseudo-resistance caused by noncompliance with treatment among patients severe resistant hypertension and analyze contributing factors.Three hundred thirty-nine (195 men) essential were studied. first group consisted 176 admitted for hospitalization exclusion a secondary cause centre (103 men); second one 163 out-patients (92 investigated time in an out-patient clinic. Unplanned blood sampling assessment serum antihypertensive drug...
Background— Catheter ablation has become an established treatment modality for a broad spectrum of ventricular tachycardias (VTs). We analyzed incidence and predictors major complications VT procedures in high-volume expert center. Methods Results— evaluated 548 consecutive patients who underwent 722 procedures, 473 (65.5%) structural heart disease the period 2006 to 2012. There were 45 (6.2%) observed 44 patients. Access site vascular most frequent (3.6%). Three (0.4%) had cardiac...
Catheter ablation (CA) for atrial fibrillation (AF) is a complex procedure that associated with higher risk of complications. This study aimed at exploring the complication rate and corresponding factors in high-volume centre routine use intracardiac echocardiography (ICE). In total 1192 consecutive AF procedures (100% ICE-guided; 96.4% 3D-navigated; point-by-point radiofrequency open-irrigated tip catheter; 22.4% robotic navigation; 25.4% repeated ablation) were performed 959 patients (aged...
During radiofrequency ablation, high electrode-tissue contact force (CF) is associated with increased risk of steam pop and perforation. The purpose this study, in patients undergoing ablation paroxysmal atrial fibrillation, was to: (1) identify factors producing CF during left (LA) pulmonary vein mapping; (2) determine the ability potential amplitude impedance to predict CF; (3) explore feasibility controlling power based on CF.A high-density map LA/pulmonary veins (median 328 sites)...
Abstract Background and Aims Patients with long atrial high-rate episodes (AHREs) ≥24 h stroke risk factors are often treated anticoagulation for prevention. Anticoagulation has never been compared no in these patients. Methods This secondary pre-specified analysis of the Non-vitamin K antagonist Oral anticoagulants patients Atrial High-rate (NOAH-AFNET 6) trial examined interactions between AHRE duration at baseline edoxaban placebo factors. The primary efficacy outcome was a composite...
Atrial high-rate episodes (AHRE) are atrial tachyarrhythmias detected by continuous rhythm monitoring pacemakers, defibrillators, or implantable cardiac monitors. occur in 10-30% of elderly patients without fibrillation. However, it remains unclear whether the presence these arrhythmias has therapeutic consequences. The AHRE increases risk stroke compared with AHRE. Oral anticoagulation would have potential to reduce but is also associated a rate major bleeding ∼2%/year. appears be lower...
Abstract Aims A pulsed electric field (PF) energy source is a novel potential option for catheter ablation of ventricular arrhythmias (VAs) as it can create deeper lesions, particularly in scarred tissue. However, very limited data exist on its efficacy and safety. This prospective observational study reports the initial experience with VA using focal PF. Methods results The population consisted 44 patients (16 women, aged 61 ± 14years) either frequent premature complexes (VPCs, 48%) or...
Objective: It has been repeatedly proven that statins improve endothelial function in isolated hypercholesterolaemia but there is far less evidence the case of combined hyperlipidaemia. Studies assessing effects fibrates on endothelium have neglected. Therefore, we conducted a trial which fenofibrate and atorvastatin monotherapy both endothelium-dependent vascular reactivity biochemical parameters were compared patients with Methods: 29 otherwise healthy males (aged 47.4±7.8 years)...
Complications of catheter ablation for atrial fibrillation (AF) are frequently related to vascular access. We hypothesized that ultrasound-guided (USG) venipuncture may facilitate the procedure and reduce complication rates.We conducted a multicentre, randomized trial in patients undergoing AF on uninterrupted anticoagulation therapy. The study enrolled consecutive 320 (age: 63 ± 8 years; male: 62%) were USG or conventional 1:1 fashion. It was prematurely terminated due substantially...
Background: Ventricular fibrillation (VF) storm after myocardial infarction (MI) is a life-threatening condition that necessitates multiple defibrillations. Catheter ablation potentially effective treatment strategy for VF refractory to optimal medical treatment. However, its impact on patient survival has not been verified in large population. Methods: We conducted multicenter, retrospective observational study involving consecutive patients who underwent catheter of post-MI without...
Short and rare episodes of atrial fibrillation (AF) are commonly detected using implanted devices (device-detected AF) in patients with prior stroke or transient ischemic attack (TIA). The effectiveness safety oral anticoagulation TIA device-detected AF but no ECG-documented is unclear.
Stereotactic arrhythmia radiotherapy (STAR) has been proposed recently in patients with refractory ventricular tachycardia (VT).
Abstract Aims Catheter ablation is an effective treatment method for recurrent ventricular tachycardias (VTs). However, at least in part, procedural and clinical outcomes are limited by challenges generating adequate lesion size the myocardium. We investigated of VT using a novel ‘large-footprint’ catheter that allows creation larger lesions either radiofrequency (RF) or pulsed field (PF) energy. Methods results In prospectively collected case series, we describe our initial experience with...
Background:Aldosterone has been shown to substantially contribute the accumulation of collagen fibers and growth factors in arterial wall, which can increase wall stiffness. This study aimed at comparing stiffness between patients with primary aldosteronism (PA), essential hypertension (EH), normotensive controls using carotid–femoral pulse wave velocity (PWV) central augmentation index (AI).