A5091113016- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Dialysis and Renal Disease Management
- Cardiac Arrest and Resuscitation
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Vascular anomalies and interventions
- Hemodynamic Monitoring and Therapy
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Renal and Vascular Pathologies
- Peripheral Artery Disease Management
- Acute Kidney Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Heart Disease Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Arrhythmias and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
General University Hospital in Prague
2013-2025
Charles University
2016-2025
Cardion (Czechia)
2024
University of Southern Denmark
2022-2024
Czech Geological Survey
2022
Rigshospitalet
2022
Copenhagen University Hospital
2022
Zero to Three
2021
Edinburgh Cancer Research
2019
Third Way
2009
<h3>Importance</h3> Out-of-hospital cardiac arrest (OHCA) has poor outcome. Whether intra-arrest transport, extracorporeal cardiopulmonary resuscitation (ECPR), and immediate invasive assessment treatment (invasive strategy) is beneficial in this setting remains uncertain. <h3>Objective</h3> To determine whether an early approach adults with refractory OHCA improves neurologically favorable survival. <h3>Design, Setting, Participants</h3> Single-center, randomized clinical trial Prague,...
<h3>Objective:</h3> To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by American Clinical Neurophysiology Society. <h3>Methods:</h3> In this cohort study, 4 specialists, blinded outcome, evaluated prospectively recorded EEGs Target Temperature Management trial (TTM trial) that randomized 33°C vs 36°C. Routine was performed still rewarming. were classified into...
Objective: It has been repeatedly proven that statins improve endothelial function in isolated hypercholesterolaemia but there is far less evidence the case of combined hyperlipidaemia. Studies assessing effects fibrates on endothelium have neglected. Therefore, we conducted a trial which fenofibrate and atorvastatin monotherapy both endothelium-dependent vascular reactivity biochemical parameters were compared patients with Methods: 29 otherwise healthy males (aged 47.4±7.8 years)...
Objectives This cross-sectional analysis from the CZecking Heart Failure in patients with advanced Chronic Kidney Disease trial (ISRCTN18275480) examined pulmonary hypertension and right ventricular-pulmonary arterial coupling on chronic hemodialysis. The aims of this were: 1. To analyze relations between dialysis access flow current hydration; 2. structural heart changes associated uncoupling; 3. reveal prevalence, etiology severity Czech hemodialysis population.
The effects of a large arteriovenous fistula (AVF) on pulmonary perfusion remains to be elucidated. We aimed study, for the first time, real-time acute AVF regional distribution in novel porcine model. Ten healthy swine under general anesthesia were studied. was created by connection femoral artery and vein using high-diameter cannulas. closed after 30 min stabilization values recorded. then opened, new data collected reaching stable state. Continuous hemodynamic monitoring performed...
Background Cognitive deficit is a common problem in end-stage renal disease (ESRD) patients. Ultrafiltration and hemodialysis lead to profound hemodynamic changes. The aim of this pilot study was describe brain hand oxygenation values ESRD patients their changes during hemodialysis. Methods Twenty-seven treated by chronic 17 controls the same age were included study. Regional saturation oxygen (SrO 2 ) measured at frontal lobe with dialysis access using INVOS 5100C. In patients, SrO also...
<b><i>Background/Aims:</i></b> High rates of cognitive impairment (CI) are an alarming problem in patients undergoing chronic hemodialysis (HD). Its pathophysiology remains unclear and there indications that brain ischemia might be one the key causes. Cerebral tissue oxygenation, as measured by near-infrared spectroscopy, is known to decreased HD patients. However, it unknown whether CI associated or not with lower cerebral oxygenation these The primary aim our study...
Purpose Patency of mature vascular access for hemodialysis is mostly limited by the growing stenoses leading to acute thrombosis. The therapy choice usually percutaneous balloon angioplasty (PTA). However, PTA injures vessel wall and subsequent re-stenosis develops faster than de novo stenosis. Therefore, key in appropriate timing procedures – as late possible but before thrombosis develops. Ultrasonography combines morphologic functional assessment, former less precise angiography. aim this...
High-flow arteriovenous fistula (AVF) for haemodialysis leads to profound haemodynamic changes and sometimes heart failure (HF). Cardiac output (CO) is divided between the AVF body tissues. The term effective CO (COef) represents difference flow volume (Qa) better characterizes altered haemodynamics that may result in organ hypoxia. We investigated effects of Qa reduction on systemic brain oxygenation.This a single-centre interventional study. Twenty-six patients chronic with high (>1500...
The goal of vascular access creation is to achieve a functioning arteriovenous fistula (AVF) or graft (AVG). An autologous has been shown be superior AVG central venous catheters (CVCs) with lowest rate re-intervention, but vessel obstruction immaturity accounts for 20 % 54% cases primary failure AVF. This review focused on the factors influencing maturation; indication and timing preoperative mapping/creation access; ultrasound parameters AVF/AVG; early postoperative complications following...
Introduction: Late heart rate deceleration parallels the increase of systolic blood pressure during turbulence (HRT) after ventricular premature complexes (VPC). This is consistent with involvement baroreflex mechanism. Physiological background dynamics not known. Enhanced sympathetic activation and nonautonomic post‐VPC changes stroke volume have been speculated on. Methods Results: We studied 28 subjects (aged 56 ± 11 years; 20 males; 18 normal 10 abnormal left (LV) function) spontaneous...
Heart failure (HF) is a serious complication of end-stage kidney disease (ESKD). However, most data come from retrospective studies that included patients on chronic hemodialysis at the time its initiation. These are frequently overhydrated, which significantly influences echocardiogram findings. The primary aim this study was to analyze prevalence heart and phenotypes. secondary aims were (1) describe potential N-terminal pro-brain natriuretic peptide (NTproBNP) for HF diagnosis in ESKD...