Jan Rulíšek
A5012163149- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Poisoning and overdose treatments
- Respiratory Support and Mechanisms
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Renal function and acid-base balance
- Alcoholism and Thiamine Deficiency
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Ultrasound in Clinical Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Sepsis Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Cardiac Arrhythmias and Treatments
- Diabetes Management and Research
- Trauma Management and Diagnosis
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Psychedelics and Drug Studies
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
University of Southern Denmark
2022-2024
General University Hospital in Prague
2015-2024
Charles University
2014-2024
Masaryk University
2021-2024
University Hospital Kralovske Vinohrady
2023
Azienda Ospedaliera San Gerardo
2022
Copenhagen University Hospital
2022
Rigshospitalet
2022
Czech Academy of Sciences, Institute of Physiology
2014
<h3>Importance</h3> Out-of-hospital cardiac arrest (OHCA) has poor outcome. Whether intra-arrest transport, extracorporeal cardiopulmonary resuscitation (ECPR), and immediate invasive assessment treatment (invasive strategy) is beneficial in this setting remains uncertain. <h3>Objective</h3> To determine whether an early approach adults with refractory OHCA improves neurologically favorable survival. <h3>Design, Setting, Participants</h3> Single-center, randomized clinical trial Prague,...
<h3>Objective:</h3> To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by American Clinical Neurophysiology Society. <h3>Methods:</h3> In this cohort study, 4 specialists, blinded outcome, evaluated prospectively recorded EEGs Target Temperature Management trial (TTM trial) that randomized 33°C vs 36°C. Routine was performed still rewarming. were classified into...
Methanol poisonings occur frequently globally, but reports of larger outbreaks where complete clinical and laboratory data are reported remain scarce. The objective the present study was to report from mass methanol poisoning in Czech Republic 2012 addressing general epidemiology, treatment, outcomes, a protocol for use fomepizole ensuring that antidote provided most severely poisoned patients critical phase.A combined prospective retrospective case series 121 with confirmed poisoning.From...
Rationale: Because encouraging rates for hospital and long-term survival of immunocompromised patients in ICUs have been described, these are more likely to receive invasive therapies, like extracorporeal membrane oxygenation (ECMO).Objectives: To report outcomes treated with ECMO severe acute respiratory distress syndrome (ARDS) identify their pre-ECMO predictors 6-month mortality main ECMO-related complications.Methods: Retrospective multicenter study 10 international high volumes cases....
Tight glucose control (TGC) reduces morbidity and mortality in patients undergoing elective cardiac surgery, but only limited data about its optimal timing are available to date.The purpose of this article was compare the effects perioperative vs postoperative initiation TGC on adverse events surgery patients.This a single center, single-blind, parallel-group, randomized controlled trial.The setting an academic tertiary hospital.Participants were 2383 hemodynamically stable major with...
Abstract Background A recently published trial has shown no differences in outcomes between patients with new-onset supraventricular arrhythmia (SVA) septic shock treated either propafenone or amiodarone. However, these outcome data have not been evaluated relation to the presence absence of a dilated left atrium (LA). Methods Patients SVA and ventricular ejection fraction ≥35% were randomized receive intravenous (70mg bolus followed by 400-840mg/24h) amiodarone (300mg 600-1800mg/24h). They...
Introduction Cannabis is the most common recreational drug worldwide and synthetic cannabinoid receptor agonists are currently largest group of new psychoactive substances. The aim this study was to compare clinical features outcomes lone acute cannabis toxicity with agonist in a large series presentations European emergency departments between 2013-2020.
This study hypothesized that 3,4-methylenedioxymetamfetamine intoxication presents with distinct clinical features and outcomes when combined other substances of misuse, compared to mono-3,4-methylenedioxymetamfetamine intoxication. investigated the presentation acute intoxication, exclusive co-usage ethanol, 3,4-methylenedioxymetamfetamine-co-intoxication or without a focus on patient sex differences. A retrospective analysis was conducted using Euro-DEN Plus database (2013-2022), which...
Novel psychoactive substances (NPS) have been increasingly reported in the last 15-20 years. We aimed to describe presentations emergency department (ED) with acute recreational drug toxicity involving NPS.Data were extracted from European Drug Emergencies Network (Euro-DEN) Plus database for all ED (36 EDs 24 countries) between January 2014 and December 2019. Patient demographics, agents involved, clinical outcomes described subgroup of NPS was compared rest cohort.Out 43,633 Euro-DEN...
Context: Acidemia is a marker of prognosis in methanol poisoning, as well compounding formate-induced cytotoxicity. Prompt correction acidemia key treatment toxicity and methods to optimize this are poorly defined.Objective: We studied the efficiency by intermittent hemodialysis (IHD) continuous renal replacement therapy (CRRT) mass outbreak poisoning.Methods: The study was designed observational cohort study. mean time for an increase 1 mmol/L HCO3–, 0.01 unit arterial blood pH, total HCO3–...
<b><i>Background:</i></b> The regional citrate anticoagulation (RCA) induces changes in total (Ca<sup>tot</sup>) and ionized (Ca<sup>2+</sup>) calcium. As of now, we do not have much information about parallel (Mg<sup>tot</sup>) (Mg<sup>2+</sup>) magnesium. <b><i>Methods:</i></b> authors compared Mg<sup>2+</sup> Mg<sup>tot</sup> with Ca<sup>2+</sup>...
Objectives: There is some controversy as to whether there a benefit from the use of centrifugal pump compared with roller during cardiopulmonary bypass facilitate cardiac surgery. We two pumps, primary aim determining any difference in effects on inflammation after pulmonary endarterectomy surgery which required prolonged and deep hypothermic circulatory arrest. Methods: Between September 2010 July 2013, 58 elective patients undergoing were included this prospective, randomised, controlled...
Context 3,4-Methylenedioxymethamphetamine (MDMA) remains one of the most commonly used recreational drugs in Europe. Monitoring Emergency Department (ED) presentations with acute toxicity associated MDMA is important to determine trends use and harms.Methods Data were extracted from European Drug Emergencies Network (Euro-DEN) Plus database for all ED involving use, alone or combination other substances, between 1 January 2014 31 December 2017. Geographical distribution, time trends, patient...
Intermittent hemodialysis (IHD) is the modality of choice in extracorporeal treatment (ECTR) acute methanol poisoning. However, comparative clinical effectiveness intermittent versus continuous modalities (CRRT) unknown. During an outbreak mass poisoning, we therefore studied effect IHD CRRT on mortality and prevalence visual/central nervous system (CNS) sequelae survivors.The study was designed as prospective observational cohort study. Patients hospitalized with a diagnosis poisoning were...
Regular endotracheal tube cuff monitoring may prevent silent aspiration.We hypothesised that active management of the tracheal during deep hypothermic cardiac arrest would reduce subglottic aspiration. We also determined to study its effect on postoperative mechanical ventilation and incidence positive cultures.A randomised clinical trial.The was conducted in a University Teaching Hospital from September 2008 November 2009.Twenty-four patients undergoing elective pulmonary endarterectomy...
Context: The influence of co-morbid conditions on the outcome acute methanol poisoning in mass outbreaks is not known.Objective: objective this to study impact burden co-morbidities, complications, and methanol-induced brain lesions hospital, follow-up, total mortality.Methods: All patients hospitalized with during a outbreak were followed prospective cohort until death or final follow-up after 6 years. age-adjusted Charlson co-morbidity index (ACCI) score was calculated for each patient. A...
The authors present a case of massive lung bleeding following pulmonary endarterectomy (PEA) that was treated with peripheral veno-venous extracorporeal membrane oxygenation (VV ECMO). patient repeatedly underwent bronchoscopy for airway blood clot obstruction and finally successfully weaned off the support. discuss indications ECMO in treatment most serious complications PEA, emphasize importance echocardiographic evaluation right ventricular function relation to indicated type...