A5019447625- Forensic Toxicology and Drug Analysis
- Poisoning and overdose treatments
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Drug-Induced Hepatotoxicity and Protection
- Opioid Use Disorder Treatment
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Global Health Care Issues
- Health disparities and outcomes
- Treatment of Major Depression
- Substance Abuse Treatment and Outcomes
- Restraint-Related Deaths
- Climate Change and Health Impacts
- Liver Disease and Transplantation
- Alcoholism and Thiamine Deficiency
- Heavy Metal Exposure and Toxicity
- Pesticide Exposure and Toxicity
- Global Public Health Policies and Epidemiology
- Healthcare Decision-Making and Restraints
- Global Maternal and Child Health
- Pharmaceutical Practices and Patient Outcomes
- Metabolomics and Mass Spectrometry Studies
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
Guy's and St Thomas' NHS Foundation Trust
2016-2025
Kings Health Partners
2016-2025
King's College London
2016-2025
St Thomas' Hospital
2010-2023
American College of Medical Toxicology
2021-2023
The University of Texas Southwestern Medical Center
2022
University of Chieti-Pescara
2021
University of Lausanne
2021
University of Hertfordshire
2021
Università Cattolica del Sacro Cuore
2021
The Global Burden of Diseases (GBD), Injuries, and Risk Factors study used the disability-adjusted life year (DALY) to quantify burden diseases, injuries, risk factors. This paper provides an overview injury estimates from 2013 update GBD, with detailed information on incidence, mortality, DALYs rates change 1990 for 26 causes injury, globally, by region country.Injury mortality was estimated using extensive GBD database, corrections ill-defined cause death ensemble modelling tool. Morbidity...
In the Global Burden of Disease Study 2013 (GBD 2013), knowledge about health and its determinants has been integrated into a comparable framework to inform policy. Outputs this analysis are relevant current policy questions in England elsewhere, particularly on inequalities. We use GBD data mortality causes death, disease injury incidence prevalence analyse burden as whole, English regions, within each region by deprivation quintile. also assess attributable potentially preventable risk...
<h3>Importance</h3> Understanding global variation in firearm mortality rates could guide prevention policies and interventions. <h3>Objective</h3> To estimate due to injury deaths from 1990 2016 195 countries territories. <h3>Design, Setting, Participants</h3> This study used deidentified aggregated data including 13 812 location-years of vital registration generate estimates levels death by age-sex-year-location. The proportion suicides which a was the lethal means combined with an per...
Mental health is a public issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends the status populations and changes leading causes disease burden over time.
Mephedrone is a synthetic cathinone that commonly used as recreational drug among those who attend nightclubs. There have been increasing reports of toxicity associated with its use and it was controlled Class B under the Misuse Drugs Act (1971) in UK on 16 April 2010. has suggestion from media mephedrone common children/students but there no data prevalence general population. The aim this study to determine frequency school college/university aged individuals collect sources acute harm...
In May 2010, a team of national and international organizations was assembled to investigate children's deaths due lead poisoning in villages northwestern Nigeria.Our goal determine the cause childhood outbreak, risk factors for child mortality, identify children < 5 years age need emergency chelation therapy poisoning.We administered cross-sectional, door-to-door questionnaire two affected villages, collected blood from 2-59 months age, obtained soil samples family compounds. Descriptive...
Context. Previous reports of acute toxicity/harm associated with mephedrone use have been based on self-reported use; toxicological screening has not undertaken in these cases to determine whether used. Objective. To report the first case series analytically confirmed mephedrone-related toxicity. Materials and methods. Serum samples were collected from individuals presenting an emergency department (ED) toxicity related use. Toxicological analysis, by gas-chromatography coupled...
The supply of recreational drugs has changed and users increasingly buy 'legal highs' over the Internet. Use these is common there a potential for significant toxicity associated with their use.To determine content legal highs available purchase in UK whether remains consistent.Twenty-six were purchased monthly from five different Internet sites 6 months. These analysed to products any changes this time period.All supplied initially, but was decline month by month. following drug classes...
Ketamine was originally synthesised for use as a dissociative anaesthetic, and it remains widely used legitimately this indication. However, there is increasing evidence of non-medical recreational ketamine, particularly in individuals who frequent the night-time economy. The population-level sub-population (clubbers) prevalence ketamine not known but likely to be similar, or slightly lower than, that other drugs such cocaine, MDMA, amphetamine. predominant features acute toxicity associated...
There is evidence of increasing use the synthetic cathinone mephedrone (4-methylmethcathinone), particularly amongst clubbers. However, there have only two single case reports toxicity. The aim this study to report pattern clinical toxicity seen with use.We describe 15 patients who presented our Emergency Department following self-reported use. Significant features included agitation in 53.3%, tachycardia 40%, systolic hypertension 20% and seizures 20%. Twenty per cent required treatment...
Aim: To assess the prevalence of use established illegal psychoactive drugs and emergent drugs, so-called "legal highs", amongst gay club-goers who are considered to be "early adopters" drug trends.Design: Three in situ surveys were conducted July 2010 with customers at two dance clubs (nightclubs) an area known for its "gay-friendly" night time economy. The assessed self-reported lifetime, past year, month, fieldwork day planned highs".Setting: This is a field study.Participants:...
Abstract Our objective was to identify microRNA (miRNA) biomarkers of drug-induced liver and kidney injury by profiling the circulating miRNome in patients with acetaminophen overdose. Plasma miRNAs were quantified age- sex-matched overdose (N = 27) without organ (APAP-TOX APAP-no TOX, respectively). Classifier tested a separate cohort 81). miRNA specificity determined non-acetaminophen murine models. Sensitivity stratification at hospital presentation 67). From 1809 miRNAs, 75 3-fold or...
<b><i>Background/Aims:</i></b> To assess whether novel psychoactive substances (NPS) displace established club drugs, supplement them or act as drugs of initiation via a study the relationship between mephedrone, ecstasy pills, cocaine and MDMA powder amongst club-goers considered to be ‘early adopters' psychostimulant/club drug trends. <b><i>Methods:</i></b> In situ surveys were conducted with 308 customers in two south London gay dance clubs...
A range of "Herbal High" products were tested for synthetic cannabinoids (cannabinomimetics) to qualitatively determine and compare their individual relative content. Liquid chromatography-high resolution accurate mass spectrometry was used rapidly screen samples a cannabinomimetics using mono-isotopic masses derived from the elemental composition target analytes. screening database over 140 compounds created. This approach, combined with further tandem spectrometric experiments, also...
Context. Despite the potential for recreational drugs and new psychoactive substances (NPSs) to cause significant morbidity mortality, there is limited collection of systematic data on acute drug/NPS toxicity in Europe. Objective. To report collected by a network sentinel centres across Europe with specialist clinical research interest NPS address this knowledge gap. Methods. Sixteen 10 European countries (Denmark, Estonia, France, Germany, Ireland, Norway, Poland, Spain, Switzerland UK) all...
There has been a significant change in the use of recreational drugs last 5–10 years with increasing availability and range different new (or novel) psychoactive substances (NPS)...
Aim: To conduct a follow-up study to assess the prevalence of use and popularity emergent psychoactive drugs (“legal highs”), amongst London club-goers 12 months after previous surveys in same location.Design: Four situ were conducted July 2011 at two fieldwork sites as self-reported both illegal “legal highs”.Setting: Field night-time economy South London, UK.Participants: 315 customers “gay-friendly” dance clubs.Measurements: Two-page research instrument designed for drug surveys.Findings:...
Extracorporeal treatments (ECTRs), such as hemodialysis and hemoperfusion, are used in poisoning despite a lack of controlled human trials demonstrating efficacy. To provide uniform recommendations, the EXTRIP group was formed an international collaboration among recognized experts from nephrology, clinical toxicology, critical care, or pharmacology supported by over 30 professional societies. For every poison, benefit ECTR is weighed against associated complications, alternative therapies,...
Paracetamol overdose is common but patient stratification suboptimal. We investigated the usefulness of new biomarkers that have either enhanced liver specificity (microRNA-122 [miR-122]) or provide mechanistic insights (keratin-18 [K18], high mobility group box-1 [HMGB1], and glutamate dehydrogenase [GLDH]). The use these could help stratify patients for their risk injury at hospital presentation.
In September 2012 the UK's Commission on Human Medicines (CHM) recommended changes in management of paracetamol poisoning: use a single '100 mg l(-1) ' nomogram treatment line, ceasing risk assessment, treating all staggered/uncertain ingestions and increasing duration initial acetylcysteine (NAC) infusion from 15 to 60 min. We evaluated effect this presentation, admission, treatment, adverse reactions costs poisoning.Data were prospectively collected adult patients presenting three large UK...