A5049307189- Opioid Use Disorder Treatment
- Poisoning and overdose treatments
- Pain Management and Opioid Use
- Pharmaceutical Practices and Patient Outcomes
- Prenatal Substance Exposure Effects
- Potassium and Related Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Diabetes Treatment and Management
- Drug-Induced Hepatotoxicity and Protection
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Pain Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Pharmacogenetics and Drug Metabolism
- Diabetes Management and Research
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Primary Care and Health Outcomes
- Maternal Mental Health During Pregnancy and Postpartum
University of Toronto
2016-2025
Sunnybrook Hospital
2016-2025
Institute for Clinical Evaluative Sciences
2016-2025
Sunnybrook Research Institute
2016-2025
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2015-2024
SickKids Foundation
2009-2024
3M (United States)
2012-2024
St Michael's Hospital
2015-2024
St. Michael's Hospital
2009-2023
The Randomized Aldactone Evaluation Study (RALES) demonstrated that spironolactone significantly improves outcomes in patients with severe heart failure. Use of angiotensin-converting-enzyme (ACE) inhibitors is also indicated these patients. However, life-threatening hyperkalemia can occur when drugs are used together.We conducted a population-based time-series analysis to examine trends the rate prescriptions and hospitalization for ambulatory before after publication RALES. We linked...
<h3>Background</h3> Prior studies suggest that unintended medication discrepancies represent errors are common at the time of hospital admission. These particularly worthy attention because they not likely to be detected by computerized physician order entry systems. <h3>Methods</h3> We prospectively studied patients reporting use least 4 regular prescription medications who were admitted general internal medicine clinical teaching units. The primary outcome was (errors) between physicians'...
<b>Background:</b> Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance this drug interaction is unknown. <b>Methods:</b> We conducted a population-based nested case–control study among patients aged 66 years or older who commenced between Apr. 1, 2002, and Dec. 31, 2007, following hospital discharge after treatment acute myocardial infarction. cases in our were those readmitted with infarction within 90 days discharge....
Context Drug-drug interactions are a preventable cause of morbidity and mortality, yet their consequences in the community not well characterized. Objective To determine whether elderly patients admitted to hospital with specific drug toxicities were likely have been prescribed an interacting week prior admission. Design Three population-based, nested case-control studies. Setting Ontario, Canada, from January 1, 1994, December 31, 2000. Patients All Ontario residents aged 66 years or older...
Opioids are widely prescribed for chronic nonmalignant pain, often at doses exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective this study was to characterize relationship between dose and opioid-related mortality.We conducted a population-based nested case-control Ontario, Canada, residents aged 15 64 years who were eligible publicly funded prescription drug coverage had received an...
Chronic noncancer pain includes any painful condition that persists for at least three months and is not associated with malignant disease.[1][1] According to seven national surveys conducted between 1994 2008, 15%–19% of Canadian adults live chronic pain.[2][2]
<h3>Importance</h3> Opioid prescribing and overdose are leading public health problems in North America, yet the precise burden has not been quantified. <h3>Objective</h3> To examine of opioid-related mortality across United States over time. <h3>Design, Setting, Participants</h3> This study used a serial cross-sectional design which cross sections were examined at different time points to investigate deaths from causes between January 1, 2001, December 31, 2016. <h3>Main Outcomes...
<h3>Background</h3> Suicide is a leading cause of death, and rates are especially high among the elderly. Medical illnesses may predispose to suicide, but few controlled studies have examined association between specific diseases suicide. We explored relationship treatment for several risk suicide in elderly patients using population-based approach. <h3>Methods</h3> All Ontario residents 66 years or older who committed January 1, 1992, December 31, 2000, were identified from provincial...
<b>Introduction:</b> Opioid-related mortality appears to be increasing in Canada. We examined the true extent of problem and impact introduction long-acting oxycodone. <b>Methods:</b> trends prescribing opioid analgesics province Ontario from 1991 2007. reviewed all deaths related use between 2004. linked 3271 these administrative data examine patients’ health care services before death. Using time-series analysis, we determined whether addition oxycodone provincial drug formulary January...
Background Prescription opioid use is highly associated with risk of opioid-related death, 1 every 550 chronic users dying within approximately 2.5 years their first prescription. Although gabapentin widely perceived as safe, drug-induced respiratory depression has been described when used alone or in combination other medications. Because and opioids are both commonly prescribed for pain, the likelihood co-prescription high. However, no published studies have examined whether concomitant...
The implications of the causal and ubiquitous use, by doctors health-workers politicians, word 9patient9 are here discussed. Given that many this noun do not include health or normality (rather contrary), it is questionable who, if anyone, profits from its indiscriminate use--and even, at all.
To examine the risk of new onset diabetes among patients treated with different HMG-CoA reductase inhibitors (statins).Population based cohort study time to event analyses estimate relation between use particular statins and incident diabetes. Hazard ratios were calculated determine effect dose type statin on diabetes.Ontario, Canada.All aged 66 or older without who started treatment from 1 August 1997 31 March 2010. The analysis was restricted users had not been prescribed a in at least...
Gatifloxacin has been associated with both hypoglycemia and hyperglycemia. We examined dysglycemia-related health outcomes various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years age or older.We conducted two population-based, nested case-control studies. In the first, case patients were persons treated hospital for after outpatient treatment macrolide, second-generation cephalosporin, respiratory fluoroquinolone (gatifloxacin, levofloxacin,...
Thiazolidinediones (TZDs), used to treat type 2 diabetes, are associated with an excess risk of congestive heart failure and possibly acute myocardial infarction. However, the association between TZD use cardiovascular events has not been adequately evaluated on a population level.To explore therapy failure, infarction, mortality compared treatment other oral hypoglycemic agents.Nested case-control analysis retrospective cohort study using health care databases in Ontario. We included...
<h3>Background</h3> Proton pump inhibitors (PPIs) cause interstitial nephritis and are an underappreciated of acute kidney injury. We examined the risk injury in a large population older patients receiving PPIs. <h3>Methods</h3> conducted population-based study involving Ontario residents aged 66 years who initiated PPI therapy between Apr. 1, 2002, Nov. 30, 2011. used propensity score matching to establish highly comparable reference group control patients. The primary outcome was hospital...
Abstract Clinical question What is the role of medical cannabis or cannabinoids for people living with chronic pain due to cancer non-cancer causes? Current practice Chronic common and distressing associated considerable socioeconomic burden globally. Medical increasingly used manage pain, particularly in jurisdictions that have enacted policies reduce use opioids; however, existing guideline recommendations are inconsistent, remains illegal therapeutic many countries. Recommendation The...
Importance Opioid-related harms constitute a major public health crisis in the US, and this has worsened during COVID-19 pandemic. Objectives To characterize societal burden of unintentional opioid-related deaths US describe changing mortality patterns Design, Setting, Participants A serial cross-sectional study examined all evaluated annually from calendar years 2011 to 2021. Main Outcomes Measures The opioid toxicity–related was estimated 2 ways. First, proportion that were attributable...
<h3>Background</h3> Recent debate has emerged regarding the cardiovascular safety of selective cyclooxygenase 2 inhibitors and possible cardioprotective effect naproxen sodium. We compared rates acute myocardial infarction (AMI) among elderly patients dispensed inhibitors, naproxen, nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs). <h3>Methods</h3> conducted a population-based retrospective cohort study using administrative health care data from Ontario, Canada, April...
Previous studies have suggested that a patient's sex may influence the provision and outcomes of critical care. Our objective was to determine whether age are associated with differences in admission practices, processes care clinical for critically ill patients.We used retrospective cohort 466,792 patients, including 24,778 admitted consecutively adult hospitals Ontario between Jan. 1, 2001, Dec. 31, 2002. We measured associations intensive unit (ICU); use mechanical ventilation, dialysis...