A5019759811- Poisoning and overdose treatments
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Opioid Use Disorder Treatment
- Emergency and Acute Care Studies
- Psychedelics and Drug Studies
- Substance Abuse Treatment and Outcomes
- Neuroscience of respiration and sleep
- Palliative Care and End-of-Life Issues
- Alcoholism and Thiamine Deficiency
- Drug-Induced Hepatotoxicity and Protection
- Healthcare Decision-Making and Restraints
- Restraint-Related Deaths
- Obesity and Health Practices
- Cardiac Arrest and Resuscitation
- Schizophrenia research and treatment
- Patient Dignity and Privacy
- Global Cancer Incidence and Screening
- Ethics in medical practice
- Neurotransmitter Receptor Influence on Behavior
- Homelessness and Social Issues
- Prenatal Substance Exposure Effects
- Pesticide Exposure and Toxicity
- Veterinary Pharmacology and Anesthesia
- Pharmacovigilance and Adverse Drug Reactions
Kings Health Partners
2016-2025
Guy's and St Thomas' NHS Foundation Trust
2016-2025
King's College London
1994-2021
St Thomas' Hospital
2004-2019
HM Prison and Probation Service
1995-2001
University of London
1994
Birmingham City Hospital
1985
Context. Despite the potential for recreational drugs and new psychoactive substances (NPSs) to cause significant morbidity mortality, there is limited collection of systematic data on acute drug/NPS toxicity in Europe. Objective. To report collected by a network sentinel centres across Europe with specialist clinical research interest NPS address this knowledge gap. Methods. Sixteen 10 European countries (Denmark, Estonia, France, Germany, Ireland, Norway, Poland, Spain, Switzerland UK) all...
There has been a significant change in the use of recreational drugs last 5–10 years with increasing availability and range different new (or novel) psychoactive substances (NPS)...
Psychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this which drugs are most frequently implicated. We describe a European case series of psychosis toxicity, estimate the frequency for different drugs.
This article is commented on by Bateman DN and Dear JW. Should we treat very large paracetamol overdose differently? Br J Clin Pharmacol 2017; 83: 1163-5. https://doi.org/10.1111/bcp.13279 AIMS: Treatment of (acetaminophen) with acetylcysteine standardized, dose determined only patient weight. The validity this approach for massive overdoses has been questioned. We systematically compared outcomes in non-massive overdoses, to guide whether alternative treatment strategies should be...
Introduction Cannabis is the most common recreational drug worldwide and synthetic cannabinoid receptor agonists are currently largest group of new psychoactive substances. The aim this study was to compare clinical features outcomes lone acute cannabis toxicity with agonist in a large series presentations European emergency departments between 2013-2020.
Context: Synthetic cannabinoid receptor agonists are the largest group of new psychoactive substances reported in last decade; this study we investigated how commonly these drugs found patients presenting to Emergency Department with acute recreational drug toxicity.Methods: We conducted an observational cohort enrolling consecutive adult (ED) London (UK) January–July 2015 (6 months) toxicity. Residual serum obtained from a sample taken as part routine clinical care was analyzed using...
This study hypothesized that 3,4-methylenedioxymetamfetamine intoxication presents with distinct clinical features and outcomes when combined other substances of misuse, compared to mono-3,4-methylenedioxymetamfetamine intoxication. investigated the presentation acute intoxication, exclusive co-usage ethanol, 3,4-methylenedioxymetamfetamine-co-intoxication or without a focus on patient sex differences. A retrospective analysis was conducted using Euro-DEN Plus database (2013-2022), which...
The aim of the study was to compare self-reported and analytically confirmed substance use in cases acute recreational drug toxicity.We performed a retrospective analysis emergency department presentations toxicity over 2 years (October 2013 September 2015) within European Drug Emergencies Network Plus project.Among 10,956 during period, 831 could be included. Between toxicological results, highest agreement found for heroin (86.1%) cocaine (74.1%), whereas inhalants, poppers, magic...
To analyse the relative percentage of acute recreational drug toxicity emergency department (ED) presentations involving main groups according to age and sex investigate different patterns based on strata.We analysed all patients with included by Euro-DEN Plus dataset (22 EDs in 14 European countries) between October 2013 December 2016 (39 months). Drugs were grouped as: opioids, cocaine, cannabis, amphetamines, gamma-hydroxybutyrate (GHB), hallucinogens, new psychoactive substances (NPS),...
Novel psychoactive substances (NPS) have been increasingly reported in the last 15-20 years. We aimed to describe presentations emergency department (ED) with acute recreational drug toxicity involving NPS.Data were extracted from European Drug Emergencies Network (Euro-DEN) Plus database for all ED (36 EDs 24 countries) between January 2014 and December 2019. Patient demographics, agents involved, clinical outcomes described subgroup of NPS was compared rest cohort.Out 43,633 Euro-DEN...
Objective: To analyse the epidemiology, clinical picture and emergency department (ED) management of a large series patients who presented to European EDs after cocaine consumption, comparing data from powder (C1 group) crack (C2 consumers. Methods: Between October 2013 December 2016, Euro-DEN Plus Registry recorded 17,371 consecutive acute recreational drug toxicity presentations 22 in 14 countries. Epidemiological demographic data, co-ingestion alcohol other drugs, features, ED outcome...
This study aimed to characterize patients admitted critical care following Emergency Department (ED) presentation with acute recreational drug toxicity and identify determinants of admission care. A retrospective multicenter matched case-control was conducted by the European Drug Network Plus (Euro-DEN Plus) over period 2014–2021. The cases were ED presentations care, controls consisted medically discharged directly from ED. potential assessed through multivariable conditional stepwise...
Objectives: In May 2016, the Psychoactive Substances Act (PSA) came into effect in UK making it an offence to produce or supply new psychoactive substances (NPS). The aim of this study was determine whether associated with a change Emergency Department (ED) presentations acute NPS toxicity.Method: ED our inner-city hospital London, UK, toxicity 12 months before and after PSA introduction [June 2015–May 2016 (2015/2016) June 2016–May 2017 (2016/2017)] were obtained from database. following...
Context 3,4-Methylenedioxymethamphetamine (MDMA) remains one of the most commonly used recreational drugs in Europe. Monitoring Emergency Department (ED) presentations with acute toxicity associated MDMA is important to determine trends use and harms.Methods Data were extracted from European Drug Emergencies Network (Euro-DEN) Plus database for all ED involving use, alone or combination other substances, between 1 January 2014 31 December 2017. Geographical distribution, time trends, patient...
Background This study was conducted to retrospectively assess the relationships between: rhabdomyolysis (quantified by creatine kinase (CK) activity) and kidney injury serum creatinine concentration), sex, age, body temperature on admission, presence of seizures, agitation or aggression in patients presenting Emergency Department with acute recreational drug toxicity. We also investigated association substances ingested. Methods All presentations 16 sentinel Euro-DEN centres 10 European...
Abstract Background Isotonitazene is a novel opioid that was first reported in Europe 2019. There have been no reports of the detection isotonitazene patients presenting to emergency department with acute drug toxicity. Aim an increase presentations our toxicity August 2021. We aim describe this outbreak and provide detail on two cases which quantified serum samples. Methods Serum samples were available for comprehensive toxicological analysis presentations. Written consent obtained analysed...
Background and importance Patients who use recreational drugs frequently co-ingest ethanol, which is considered a central nervous system (CNS) depressant. The clinical relevance of this in acute toxicity involving other CNS depressants not well described. Objective To assess the impact ethanol co-use patients presenting to emergency department (ED) with depressant drugs. Design, settings participants A retrospective multicentre study using data from Euro-DEN Plus database January 2014...
To investigate if clinical features associated with acute cannabis intoxication in patients presenting to Emergency Departments for medical assistance differ according patient age and sex.We analysed presentations the Euro-DEN Plus dataset from 2014 2019 which was only drug involved (except alcohol), age, sex alcohol co-ingestion had been recorded. Age considered as categorical (five groups; <20, 20-29, 30-39, 40-49 ≥50 years), binary variable (male/female). We evaluated 12 key recorded...