A5083410146- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Cardiovascular Function and Risk Factors
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Patient Safety and Medication Errors
- Reconstructive Surgery and Microvascular Techniques
- Family and Patient Care in Intensive Care Units
- Neuroscience of respiration and sleep
- Intracranial Aneurysms: Treatment and Complications
- COVID-19 and healthcare impacts
- Transplantation: Methods and Outcomes
- COVID-19 diagnosis using AI
- Emergency and Acute Care Studies
- Breast Implant and Reconstruction
- Cardiac Arrhythmias and Treatments
- Hemodynamic Monitoring and Therapy
- Organ Transplantation Techniques and Outcomes
- Trauma Management and Diagnosis
- Cardiovascular Effects of Exercise
Ente Ospedaliero Cantonale
2016-2025
University of Geneva
2018-2025
Università della Svizzera italiana
2024
Ospedale Regionale di Mendrisio
2009-2023
University Hospital of Geneva
2020-2023
MRC Epidemiology Unit
2019-2021
Repubblica e Cantone Ticino
2021
Weatherford College
2021
University of Bern
2019
University Hospital of Bern
2019
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of embolism. Its incidence following embolism debated. Active screening for CTEPH in patients with acute yet to be recommended. This prospective, multicentre, observational study (Multicentre Observational Screening Survey the Detection Thromboembolic Pulmonary Hypertension Following Embolism (INPUT on PE); ISRCTN61417303 ) included from 11 centres Switzerland March 2009 November 2016. possible was performed at 6,...
Right ventricular (RV) adaptation is an important prognostic factor in acute and chronic pulmonary hypertension. Pulmonary vascular basal tone hypoxic reactivity are known to vary widely between species. We investigated how RV hypertension preserved species with low, intermediate, high resistance reactivity. Acute was induced by hypoxia, distal embolism, proximal constriction anesthetized dogs (n = 10), goats 8), pigs 8). vessels were assessed flow-pressure curves impedance quantify...
Pulmonary hypertension on heart failure (HF) limits exercise capacity and survival probably because of associated right ventricular (RV) failure. This study investigated the mechanisms RV function adaptation to early pulmonary in experimental HF. Seven weeks rapid pacing six dogs induced a HF characterized by cardiomegaly decreased left ejection fraction. Compared with eight control dogs, was borderline, mean artery pressure increased only 23 ± 2 (means SE) mmHg. However, vascular impedance...
The time constant of the pulmonary circulation, or product vascular resistance (PVR) and compliance (Ca), called RC-time, has been reported to remain over a wide range pressures, etiologies hypertension, treatments. We wondered if increased wave reflection on proximal obstruction, like in operable chronic thromboembolic might also decrease RC-time thereby increase pulse pressure right ventricular afterload. Pulmonary hypertension variable severity was induced either by obstruction (pulmonary...
Adverse events (AEs) frequently occur in intensive care units (ICUs) and affect negatively patient outcomes. Targeted improvement strategies for safety are difficult to evaluate because of the intrinsic limitations reporting crude AE rates. Single interventions influence positively quality care, but a multifaceted approach has been tested only selected cases. The present study was designed rate, types, contributing factors emerging AEs test hypothesis that intervention on medication might...
Objective Medication reconciliation (MedRec) is a relevant safety procedure in medication management at transitions of care. The aim this study was to evaluate the impact MedRec, including best possible history (BPMH) compared with standard patients admitted an internal medicine ward. Design Prospective interventional study. Data were analysed using descriptive statistics followed by univariate and multivariate Poisson regression models zero-inflated model. Setting Internal ward secondary...
Background/Objectives: Concerns about isotretinoin may affect both initiation and adherence in acne patients. We conducted a student-based transversal study including participants with knowledge on to assess related concerns factors as well the impact of an fact sheet before–after design. To our knowledge, no such surveys have been published evaluate concerns. Method: An online questionnaire treatment was distributed by social media. The written information assessed. Results: A total 528 had...
To compare risk factors, clinical presentation, and outcomes after posterior circulation arterial ischemic stroke (PCAIS) anterior (ACAIS) in neonates children.In this international multicenter observational study including children up to 18 years of age with (AIS), we compared radiologic features according location.Of 2,768 AIS cases, 507 (18%) were located the circulation, 1,931 (70%) 330 (12%) involved both. PCAIS was less frequent (8.8% vs 22%, p < 0.001). Children older than ACAIS...
The primary objective of this study was to compare measurements skeletal muscle index (SMI), visceral adipose tissue (VAT) and subcutaneous (SAT) at the level L3, on subjects who underwent computed tomography (CT) magnetic resonance imaging (MRI) examinations within a three-month period. secondary automatic semi-automatic quantifications same values for CT images.Among MRI our Institution between 2011 2020, exclusion criteria were: presence extensive artifacts; images not including whole...
The purpose of this study was to determine the site increased resistance using arterial occlusion technique in patients with severe pulmonary hypertension. Pulmonary vascular partitioned and venous components based on double exponential fitting analysis artery pressure decay curve: after balloon 36 hypertension (PAH); at baseline during inhalation 20 parts per million nitric oxide (NO); four chronic thromboembolic hypertension; two veno-occlusive disease. In PAH, baseline, mean 56±2 mmHg...
Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter vessels, raising risk cerebral ischemia. The aim this study was to characterize effects moderate short-term in patients with severe TBI by using concomitant monitoring metabolism, tissue oxygen tension (PbrO2), hemodynamics transcranial color-coded duplex sonography (TCCD).This prospective...
<h3>BACKGROUND AND PURPOSE:</h3> Ischemic stroke can be mimicked by nonischemic conditions. Due to emphasis on the rapid treatment of acute ischemic stroke, it is crucial identify these conditions avoid unnecessary therapies and potential complications. We investigated performance multimodal CT protocol (unenhanced brain CT, CTA, CTP) discriminate mimics from stroke. <h3>MATERIALS METHODS:</h3> retrospectively selected studies performed for clinical suspicion in our center a 24-month period,...
This study aimed to characterize patients admitted critical care following Emergency Department (ED) presentation with acute recreational drug toxicity and identify determinants of admission care. A retrospective multicenter matched case-control was conducted by the European Drug Network Plus (Euro-DEN Plus) over period 2014–2021. The cases were ED presentations care, controls consisted medically discharged directly from ED. potential assessed through multivariable conditional stepwise...
Objective To characterize the dose-related effects of dobutamine on pulmonary vascular tone and associated changes in right ventricular afterload canine microembolic lung injury. Design Prospective, interventional study. Setting University laboratory. Subjects Ten anesthetized ventilated dogs. Interventions Right heart catheterization for measurement resistance by multipoint mean artery pressure (Ppa)/cardiac output (Q) plots, partitioning occlusion method, determination arterial input...
<h3>Importance</h3> According to international recommendations, hospitals should use medication reconciliation prevent errors and improve patient safety. <h3>Objective</h3> To assess the impact of at hospital admission on patient-centered health care outcomes. <h3>Design, Setting, Participants</h3> This parallel group, open-label randomized controlled trial used centralized randomization intervention group (ie, individuals with reconciliation) or control only standard, physician-acquired...
Abstract Background All over the world, SARS-CoV-2 pneumonia is causing a significant short-term morbidity and mortality, but medium-term impact on lung function quality of life affected patients are still unknown. Methods In this prospective observational study, 39 with were recruited from single COVID-19 hospital in Southern Switzerland. At three months underwent radiological functional follow-up through CT scan, tests, 6 min walking test. Furthermore, was assessed self-reported...
All over the world, SARS-CoV-2 pneumonia is causing a significant short and medium-term morbidity mortality, with reported persisting symptoms, radiological lung alterations up to 6 months after symptoms onset. Nevertheless, 1-year impact on affected patients still poorly known. In this prospective observational study, 39 were recruited from single COVID-19 hospital in Southern Switzerland. They underwent 3-month follow-ups. At 1 year, 38 functional follow-up through function tests six...
Sildenafil has been shown to be an effective treatment of pulmonary arterial hypertension and is believed present with selectivity. This study was designed determine the site action sildenafil compared inhaled nitric oxide (NO) intravenous sodium nitroprusside (SNP), known as selective nonselective vasodilators, respectively. Inhaled NO (40 ppm), maximum tolerated doses SNP sildenafil, (5 microg x kg(-1) min(-1) 0.1 mg h(-1)), respectively, were administered eight dogs ventilated in hypoxia....
Background Family satisfaction of critically ill patients has gained increased interest as important indicator to evaluate the quality care in intensive unit ( ICU ). The family questionnaire FS‐ICU 24 ) is a well‐established tool assess such settings. We tested hypothesis that an intervention, aiming at improved communication between health professionals and patients' next kin improves satisfaction, assessed by . Methods Using multicenter before‐and‐after study design, we evaluated...
Abstract Aims Myocardial injury (MINJ) in Coronavirus disease 2019 (COVID-19) identifies individuals at high mortality risk but its clinical relevance is less well established for Influenza and no comparative analyses evaluating frequency implications of MINJ among hospitalized patients with or COVID-19 are available. Methods results Hospitalized adults laboratory confirmed A B underwent highly sensitive cardiac T Troponin (hs-cTnT) measurement admission four regional hospitals Canton...
The purpose of the present study was to analyze clinical features patients with traumatic brain injury (TBI), their age-related outcomes and determinants long-term outcome.This retrospective cohort conducted in a level I University Swiss trauma center. Consecutive moderate severe TBI admitted for more than 48 hours Intensive Care Unit (ICU) were included. Patients' characteristics, management during ICU stay, prognostic scores analyzed.Hundred-seventy-four (72% males, mean age 49 years)...