A5067225218- Pulmonary Hypertension Research and Treatments
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Retinal Imaging and Analysis
- Systemic Lupus Erythematosus Research
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Hormonal Regulation and Hypertension
- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- Chronic Disease Management Strategies
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 Clinical Research Studies
- Retinal and Optic Conditions
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Renal function and acid-base balance
- Cardiovascular Effects of Exercise
- IL-33, ST2, and ILC Pathways
- Electrolyte and hormonal disorders
- Sodium Intake and Health
Université de Montpellier
2015-2024
Centre Hospitalier Universitaire de Montpellier
2015-2024
Inserm
2015-2024
Centre National de la Recherche Scientifique
2016-2024
Institut Pasteur
2024
Hôpital Lapeyronie
2013-2023
Université d'Angers
2023
Centre Hospitalier Universitaire d'Angers
2023
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2014-2022
Hôpital Arnaud de Villeneuve
2018
Objective A transient increase in pulmonary arterial (PA) pressure can persistently depress right ventricular (RV) contractility. We investigated the effects norepinephrine and dobutamine on RV-PA coupling this model of RV failure. Design Prospective, controlled, randomized animal study. Setting University research laboratory. Subjects Twenty-two anesthetized dogs. Interventions Animals underwent (90-min) PA constriction to induce persistent They were randomly assigned control,...
Pulmonary thromboendarterectomy (PTE) is the preferred treatment for chronic thromboembolic pulmonary hypertension (CTEPH), but persistent after PTE, as a result of either inaccessible distal thrombotic material or coexistent intrinsic small-vessel disease, remains major determinant poor outcome. Conventional preoperative evaluation unreliable in identifying patients at risk predicting postoperative hemodynamic We postulated that arterial occlusion pressure waveform analysis, technique has...
Experimental and clinical data suggest that primary aldosteronism (PA) may be associated with cardiovascular hypertrophy fibrosis, in part independent of the BP level. Whether PA also result specific deleterious effects on kidneys was less studied. In 25 patients tumoral PA, renal studies (urinary excretion proteins, GFR, effective plasma flow [ERPF], as clearances technetium-labeled diethylene triaminopentaacetic acid 131I-ortho iodohippurate, respectively) were performed both before 6 mo...
In the early phase of pandemic, we were among first to postulate that neutrophil extracellular traps (NETs) play a key role in COVID-19 pathogenesis. This exploratory prospective study based on 279 individuals showed plasma levels elastase, myeloperoxidase and circulating DNA nuclear mitochondrial origins nonsevere (NS), severe (S) postacute (PAP) patients statistically different as compared healthy individuals, revealed high diagnostic power these NETs markers respect disease severity. The...
Objective: A transient increase in pulmonary arterial (PA) pressure can persistently depress right ventricular (RV) contractility. We investigated the effects of dobutamine and levosimendan on RV-PA coupling this model RV failure. Design: Prospective, controlled, randomized animal study. Setting: University research laboratory. Subjects: Fifteen anesthetized dogs. Interventions: Transient (90-min) PA constriction to induce persistent Random assignment 5 10 μg/kg/min or 12 μg/kg for mins...
Objective: Repeated episodes of pulmonary embolism can persistently increase arterial pressure and depress right ventricular contractility. We investigated the effects levosimendan on ventricular-pulmonary coupling in this model failure. Design: Prospective, controlled, randomized animal study. Setting: University research laboratory. Subjects: Fourteen anesthetized piglets. Interventions: acute embolisms were induced with autologous blood clots to induce persistent Animals randomly assigned...
Three-month chronic systemic-to-pulmonary shunting in growing piglets has been reported as an early pulmonary arterial hypertension (PAH) model with preserved right ventricular (RV) function. We sought to determine whether prolonged might be associated more severe PAH and RV failure. Fourteen were randomized a sham operation or the anastomosis of left innominate artery trunk. Six months later, shunt was closed animals underwent haemodynamic evaluation followed by tissue sampling for...
Background: Pulmonary endarterectomy (PEA) is the gold standard treatment for patients with operable chronic thromboembolic pulmonary hypertension. However, persistent hypertension (PH) after PEA remains a major determinant of poor prognosis. A concomitant small-vessel arteriopathy in addition to artery obstruction has been suggested play an important role development PH and survival PEA. One greatest unmet needs current preoperative evaluation assess presence severity arteriopathy. Using...
In the past decade, pulse pressure has emerged as a strong predictor of cardiovascular morbidity and mortality. During aging, elevation is consequence stiffening arterial wall. The relationship between renal aging process was studied in cohort 212 patients with never-treated isolated systolic hypertension. Glomerular filtration rate effective plasma flow were measured using constant infusion technetium 99m (99mTc)-DTPA 131I-ortho-iodohippurate, respectively, timed urine collections. function...
In large epidemiological studies and using serum creatinine or estimates of glomerular filtration rate (GFR), blood pressure has emerged as a predominant determinant the age-associated decline in renal function.The present longitudinal study (median follow-up period 5.8 years) was conducted 132 never-treated patients with essential hypertension at baseline. The effect treatment on GFR effective plasma flow, estimated by urinary clearances isotopic markers, assessed.Satisfactory control...
Retinal vascular caliber has been linked with increased cardiovascular risk and is predictive of pathology, including stroke coronary heart disease. Oxidative stress, as well inflammatory mechanisms, plays a major role in the pathogenesis progression atherosclerosis, plaque rupture thrombotic propensity. The purpose this study to explore relationship between retinal calibers biomarkers oxidative stress inflammation, subjects free pathology.Cross-sectional analysis from community-dwelling...
Background. The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of renin aldosterone system (RAAS), as cellular receptor to infect cells. Since RAAS can induce and modulate pro-inflammatory responses, it could play key role in pathophysiology Covid-19. Thus, we aimed determine levels plasma indicators activation series consecutively admitted patients our clinic. Methods. Plasma were measured, among...
Background— The phosphodiesterase type-5 (PDE-5) inhibitor sildenafil has been reported to improve pulmonary arterial hypertension (PAH), but the mechanisms that account for this effect are incompletely understood. Severe characterized by defects in a signaling pathway involving angiopoietin-1 and bone morphogenetic receptor-2 (BMPR-2). We investigated effects of on hemodynamics molecules piglet overcirculation-induced model early PAH. Methods Results— Thirty 3-week-old piglets were...
Pulmonary hypertension on heart failure (HF) limits exercise capacity and survival probably because of associated right ventricular (RV) failure. This study investigated the mechanisms RV function adaptation to early pulmonary in experimental HF. Seven weeks rapid pacing six dogs induced a HF characterized by cardiomegaly decreased left ejection fraction. Compared with eight control dogs, was borderline, mean artery pressure increased only 23 ± 2 (means SE) mmHg. However, vascular impedance...
In essential hypertension, the regression of left ventricular hypertrophy is an important goal treatment. addition to treatment-associated changes in blood pressure (BP), roles other determinants regression, including dietary sodium intake, deserve investigation. present study, change echographic mass index (LVMI) was assessed 182 patients with never-treated hypertension at baseline and after 3 years treatment by angiotensin converting enzyme inhibitors or II receptor antagonists given...
Background Cardiovascular mortality is increased in patients with rheumatoid arthritis (RA). RA associated an left ventricular mass index (LVMI), a strong marker of cardiovascular mortality, and vessel abnormalities. Experimental studies have suggested that tumour necrosis factor α (TNFα) may induce LV hypertrophy. Objective To study the effect medium-term (3- 6-months) treatment TNFα inhibitor etanercept (ETN) synthetic disease-modifying antirheumatic drugs (sDMARDs) on morphological...
While several studies from China have reported COVID-19-related liver injury, there are currently no data on dysfunction in hospitalized COVID-19 patients Europe. The aim of this study was to describe the prevalence and predictive value abnormal function with COVID-19. This a retrospective cohort confirmed two referral hospitals France. Clinical, biological radiological were collected analysed. In all, 234 by RT-PCR included. Liver 66.6% admission. multivariate logistic regression, test...