Georges‐Philippe Pageaux
A5052064056- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Transplantation: Methods and Outcomes
- Systemic Lupus Erythematosus Research
- HIV/AIDS drug development and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Hepatitis Viruses Studies and Epidemiology
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Gallbladder and Bile Duct Disorders
- Galectins and Cancer Biology
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
Hôpital Saint Eloi
2016-2025
Université de Montpellier
2016-2025
Centre Hospitalier Universitaire de Montpellier
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2023
Hôpital Avicenne
2023
Institute for Regenerative Medicine & Biotherapy
2014-2022
Hospital Universitario Austral
2022
Austral University
2022
Paris-Est Sup
2022
Université Paris-Est Créteil
2015-2022
A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose not responding to medical therapy have a survival rate of approximately 30%. Since most deaths occur within 2 months, early transplantation attractive but controversial.We selected seven centers The had no prior episodes and scores 0.45 or higher according the Lille model (which calculates ranging 0 1, score ≥ indicating nonresponse an...
We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC).In a prospective-randomized open-label international trial, 525 LTx recipients HCC initially receiving mammalian target of rapamycin inhibitor-free were randomized 4 to 6 weeks after into group on (group A: 264 patients) or incorporating sirolimus B: 261). The primary endpoint was recurrence-free survival (RFS); intention-to-treat (ITT)...
Prednisolone or pentoxifylline is recommended for severe alcoholic hepatitis, a life-threatening disease. The benefit of their combination unknown.To determine whether the addition to prednisolone more effective than alone.Multicenter, randomized, double-blind clinical trial conducted between December 2007 and March 2010 in 1 Belgian 23 French hospitals 270 patients aged 18 70 years who were heavy drinkers with biopsy-proven as indicated by recent onset jaundice prior 3 months Maddrey score...
We recently identified a histological subtype of hepatocellular carcinoma (HCC), designated as "macrotrabecular-massive" (MTM-HCC) and associated with specific molecular features. In order to assess the clinical relevance this variant, we investigated its prognostic value in two large series patients HCC treated by either surgical resection or radiofrequency ablation (RFA). retrospectively included 237 samples 284 liver biopsies from RFA, respectively. Histological slides were reviewed...
The actual impact of transarterial chemoembolization before liver transplantation (LT) for hepatocellular carcinoma (HCC) on patient survival and HCC recurrence is not known. Between 1985 1998, 479 patients with in 14 French centers were evaluated LT. Among these patients, this case-control study included 100 who received LT (TACE group) control did receive (no-TACE group). Patients controls matched the pre-LT tumor characteristics, period transplantation, time spent waiting list, pre-...
Orthotopic liver transplantation (OLT) indication for hepatocellular carcinoma (HCC) is currently based on the Milan criteria. The University of California, San Francisco (UCSF) recently proposed an expansion selection criteria according to tumors characteristics explanted liver. This study: 1) assessed validity these in independent large series and 2) tested usefulness when applied pre-OLT tumor evaluation. Between 1985 1998, 479 patients were listed (LT) HCC 467 transplanted. According...
We conducted a multicenter randomized study in liver transplantation to compare standard-dose tacrolimus reduced-dose with mycophenolate mofetil reduce the occurrence of side effects. Two primary outcomes (censored criteria) were monitored during 48 weeks post-transplantation: renal dysfunction or arterial hypertension diabetes (evaluating benefit) and acute graft rejection risk). Interim analyses performed every 40 patients stop case increased risk rejection. One hundred ninety-five...
Abstract Background The potential anti-cancer effects of mammalian target rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic in the pure oncology setting, and at present, no endpoint-directed RCT has reported high-malignancy risk population immunosuppressed transplant recipients. Interestingly, since mTOR both immunosuppressive effects, they simultaneously protect against...
Alcoholic liver disease (ALD) is a major indication for transplantation (LT). Recurrent alcoholic cirrhosis (RAC) after LT can occur but has not been studied. The aims of this study were to estimate the prevalence, predictive factors, and natural history RAC LT.All patients transplanted ALD between 1990 2007 in three French centers included. diagnosis was based on histological evidence or series features combined with severe relapse.Among 1,894 adult patients, 712 survived >6 months. After...
Abstract Aims To evaluate the diagnostic performance of CT , MRI and CEUS alone in combination, for diagnosis HCC between 10 30 mm, a large population cirrhotic patients. Patients methods In multicentre prospective trial, 442 patients have been enrolled. Within month, were performed all A composite algorithm was defined to obtain more accurate gold standard. Results total 544 nodules 381 retained analysis. Eighty‐two percent male, mean age 62 years. For 10‐20 mm (n=342), sensitivity (Se)...
A joint meeting of the European Association for Study Liver (EASL) and American Diseases (AASLD) was held in London on September 30 October 1, 2017. The goals were to identify areas broad agreement disagreement, develop consensus, determine future directions ultimately reduce burden, morbidity, mortality alcohol-related liver disease (previously termed alcoholic disease). specific aims unmet needs investigation, order alcohol consumption, markers diagnosis prognosis disease, create a...
Macrotrabecular-massive hepatocellular carcinoma (MTM-HCC) is a novel morphological subtype of HCC associated with early relapse after resection or percutaneous ablation, independently classical clinical and radiological prognostic factors. The aim the present study was to identify immunohistochemical markers MTM-HCC, ease its diagnosis implementation into practice.To potential biomarkers we first analyzed gene expression profiling data from Cancer Genome Atlas further selected two candidate...
The benefits of prophylactic antibiotics for hospitalized patients with severe alcohol-related hepatitis are unclear.To determine the efficacy amoxicillin-clavulanate, compared placebo, on mortality in and treated prednisolone.Multicenter, randomized, double-blind clinical trial among biopsy-proven (Maddrey function score ≥32 Model End-stage Liver Disease [MELD] ≥21) from June 13, 2015, to May 24, 2019, 25 centers France Belgium. All were followed up 180 days. Final follow-up occurred...