A5088572554- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis C virus research
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Alcohol Consumption and Health Effects
- HIV-related health complications and treatments
- Gallbladder and Bile Duct Disorders
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Cardiac Health and Mental Health
- Anesthesia and Neurotoxicity Research
- Maternal Mental Health During Pregnancy and Postpartum
- High Altitude and Hypoxia
- Exercise and Physiological Responses
- Stress Responses and Cortisol
- Hepatitis Viruses Studies and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
Newcastle upon Tyne Hospitals NHS Foundation Trust
2020-2024
Newcastle University
2021-2024
Freeman Hospital
2021-2024
Newcastle upon Tyne Hospital
2021
Hospital Universitario Doctor Peset
2021
Universitat de València
2021
Creative Research Enterprises (United States)
2021
University Hospital of North Tees
2021
Jackson and Tull (United States)
2021
Sunderland Royal Hospital
2016
Summary Background Since 1970, there has been a 400% increase in liver‐related deaths due to the increasing prevalence of chronic liver disease United Kingdom (UK). The 2013 UK National Confidential Enquiry into Patient Outcome and Death report found that only 47% patients who died from alcohol‐related received ‘good care’ during their hospital stay. Aim To develop ‘care bundle’ for with decompensated cirrhosis, aiming ensure evidence‐based treatments are delivered within first 24 h...
In primary biliary cholangitis (PBC), static liver stiffness measurement (LSM) has proven prognostic value. However, the added value of LSM time course in this disease remains uncertain.
Uncertainty exists about how best to identify primary biliary cholangitis (PBC) patients who would benefit from second-line therapy. Existing, purely clinical, ursodeoxycholic acid (UDCA) response criteria accept degrees of liver biochemistry abnormality in responding patients, emerging data, however, suggest that any degree ongoing may, fact, be associated with an increased risk adverse outcomes. This cohort study explores the link between status, biology high-risk disease and its...
Objective Hepatitis C virus (HCV) infection is common. Although treatment effective, with oral antivirals curing >95% of patients, most individuals have comorbidities that persist long term. Therefore, our aim was to determine the prevalence potentially modifiable health problems in patients HCV and develop an care bundle identify target comorbidities. Design Cross-sectional, observational single-centre study recruited consecutive from viral hepatitis clinics. Data were collected on...
Generic fibrates are used off-label as add-in therapy for the management of primary biliary cholangitis (PBC) but with unproven long-term liver-related survival benefits. The recently developed fibrate, seladelpar, has shown promising results in clinical trials, these outcomes have been previously marred by safety concerns.We summarize existing treatment options PBC and evaluate current trial data seladelpar relation to liver biochemistry, symptomology, safety.Seladelpar leads marked...
Background and Aims. A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, a significant impact on quality life (QOL), no effective medical treatment. Allopregnanolone, neurosteroid, is positive allosteric modulator gamma-aminobutyricacid-A (GABA-A) receptors, associated disordered mood, cognition, memory. This study explored associations between allopregnanolone disease-specific QOL scoring system (PBC-40) in PBC patients. Method. Serum...
Pruritus is common and often undertreated in patients with primary biliary cholangitis (PBC). Existing treatments largely have an aging low-quality evidence base, studies included only small numbers of patients. More recent data that has added to our understanding pruritus come from clinical trials where itching was a secondary outcome measure trial designed primarily assess disease-modifying agents. This area represents unmet need the management PBC.
Objective Hepatitis C virus (HCV) infection is associated with an increased risk of cardiovascular disease (CVD) and reduced health-related quality life (HRQoL). Although physical activity (PA)/exercise has been shown to reduce CVD improve HRQoL in patients liver disease, there limited data HCV. We aimed explore the association between PA/exercise levels, HCV assess individuals’ attitudes PA/exercise. Design Cross-sectional observational study recruiting consecutive from viral hepatitis...
<h3>Introduction</h3> Cirrhosis and chronic infection with Hepatitis C Virus (HCV) is associated fatigue, depression neurocognitive deficits which profoundly affect health-related quality of life (QoL). Advances in antiviral therapy mean ~95% patients receiving treatment achieve sustained virologic response (SVR), reducing progression to cirrhosis. Whether these improved clinical outcomes translate improvements QoL has not been empirically assessed. Therefore, this study examined the...
<h3>Introduction</h3> Hepatitis C virus infection (HCV) is associated with an increased risk of cardiovascular disease (CVD) and reduced health-related quality life (HRQoL). Although physical activity (PA)/exercise has been shown to reduce CVD improve HRQoL in patients liver disease, there limited data HCV. We aimed explore the association between PA/exercise levels, HCV assess individuals' attitudes PA/exercise. <h3>Methods</h3> Cross-sectional observational study recruiting consecutive...
<h3>Introduction</h3> Transplantation is an established therapy for end-stage liver disease and there great demand donor organs. Psychosocial concerns are prevalent in patients undergoing transplant (OLT) assessment this may impact on post-transplant outcomes. In the UK no current standardised method quantifying OLT candidates' psychosocial risk. We investigated use of a risk tool assessing post-transplantation <h3>Methods</h3> A profile (mSIPAT) was retrospectively applied to all who...