A5045596231- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis C virus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Bowel Disease
- Advanced Optimization Algorithms Research
- Pancreatitis Pathology and Treatment
- Diabetes and associated disorders
- Mathematics and Applications
- Liver physiology and pathology
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Dietary Effects on Health
- Systemic Lupus Erythematosus Research
- Cardiovascular Function and Risk Factors
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Tumor Research and Treatment
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2016-2025
Hadassah Medical Center
2022
Quality and Reliability (Greece)
2014
Harvard University Press
2014
Massachusetts General Hospital
2011
University of Alberta
1973
Infliximab (IFX) is effective in the treatment of inflammatory bowel disease; however, effect often not durable. It unknown if proactive therapeutic concentration monitoring (TCM) IFX improves outcomes.This a retrospective observational study examining use TCM and titration to target for patients with disease clinical remission at tertiary care center. The primary aim was describe course who had TCM. A secondary analysis done assess this strategy superior standard care.Forty-eight were...
OBJECTIVES: Anticoagulants carry a significant risk of gastrointestinal bleeding (GIB). Data regarding the safety anticoagulation continuation/cessation after GIB are limited. We sought to determine and continuation GIB. METHODS: conducted prospective observational cohort study on consecutive patients admitted hospital who had while systemic anticoagulation. Patients were classified into two groups at discharge GIB: those resumed discontinued. in both contacted by phone 90 days following...
Hepatorenal syndrome type 1 (HRS-1) is a serious complication of advanced cirrhosis and potentially reversible form acute kidney injury that associated with rapidly deteriorating function. Liver transplantation remains the only curative treatment for decompensated cirrhosis. However, terlipressin, vasopressin analog, successfully reverses HRS-1, may improve patient survival while awaiting liver transplantation. Patients higher baseline serum creatinine have reduced response to terlipressin....
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated better long-term outcome. However, second-line therapies currently recommended only when ALP remain above 1.5 times the upper limit of normal (×ULN) after 12-month UDCA. We assessed whether, considered good responders to UDCA, were significant survival gains. Approach Results: performed a retrospective cohort study 1047 PBC who...
Primary biliary cholangitis is an autoimmune cholestatic liver disease characterized by progressive destruction of bile ducts, which can ultimately progress to chronic and cirrhosis. Ursodeoxycholic acid obeticholic are the only 2 Food Drug Administration (FDA)-approved medications for primary cholangitis. Unfortunately, up 40% patients with have incomplete response ursodeoxycholic acid, warranting essential need additional therapeutics. Peroxisome proliferator-activated receptor agonists...
Background: The Mayo Risk Score (MRS) predicts short-term mortality in primary sclerosing cholangitis (PSC) using the age, bilirubin, albumin, aspartate aminotransferase (AST), and variceal bleeding history. While MRS has been validated end-stage PSC, its ability to predict liver transplantation (LT) outcomes newly diagnosed patients without advanced disease remains unclear. This study evaluated effectiveness of predicting LT this patient population. Methods: We analyzed data from 109 adults...
INTRODUCTION: Muscle cramps are common among persons with cirrhosis and associated poor health-related quality of life. Treatment options limited. We sought to determine whether pickle juice can improve muscle cramp severity. METHODS: enrolled 82 patients a history >4 in the previous month from December 2020 2021. Patients were randomized 1:1 sips vs tap water at onset. Our primary outcome assessed 28 days was change severity measured by visual analog scale for (VAS-cramps, scaled 0–10)....
As ammonia metabolism is a complex multiorgan process, we sought to determine whether serum concentrations were associated with transplant-free survival in patients acutely decompensated cirrhosis and acute-on-chronic liver failure (ACLF).We studied 494 consecutive hospitalized between April 2007 September 2012 venous measured on hospital admission. The primary outcome was survival.Overall, rates of death or transplant within 30 90 days 23.1% (n=114) 37.7% (n=186), respectively. Forty-six...
Primary sclerosing cholangitis (PSC) is the leading indication of liver transplantation (LT) among autoimmune disease patients. There a scarcity studies comparing survival outcomes between living-donor transplants (LDLT)s and deceased-donor (DDLTs) in this population. Using United Network for Organ Sharing database, we compared 4679 DDLTs 805 LDLTs. Our outcome interest was post-LT patient graft survival. A stepwise multivariate analysis performed, adjusting recipient age, gender, diabetes...
The treatment of HBeAg-negative chronic hepatitis B (CHB) is considered to be open-ended, with no guidelines for cessation.To evaluate biochemical and virological relapse requiring retreatment in noncirrhotic CHB patients who stopped following a period prolonged viral suppression nucleotides/nucleosides.We performed single-centre retrospective chart review maintained 4-5 years on anti-viral treatment, thus subsequently treatment. primary end point composite was defined by an increase HBV DNA...
To objectively assess when gastroenterology (GI) fellows achieve technical competency to perform colonoscopy independently.New guidelines the procedural of GI in training have been developed. Although comprehensive, they do not account for quality metrics which independently practicing gastroenterologists are held.We performed a prospective study examining consecutive colonoscopies by from November 2013 through March 2014 at an academic medical center. Using brief postprocedure questionnaire...
Autoimmune liver diseases (AILDs): autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and sclerosing (PSC) have different survival outcomes after transplant (LT). Outcomes are influenced by factors including disease burden, medical comorbidities, socioeconomic variables.