Jérôme Dumortier
A5091564657- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Transplantation: Methods and Outcomes
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Polyomavirus and related diseases
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neurological Complications and Syndromes
- Abdominal vascular conditions and treatments
- Gastrointestinal Tumor Research and Treatment
- Viral-associated cancers and disorders
- Gastroesophageal reflux and treatments
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Pancreatic and Hepatic Oncology Research
Hôpital Edouard Herriot
2016-2025
Hospices Civils de Lyon
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Inserm
2000-2024
ERN RARE-LIVER
2023-2024
HCL Technologies (India)
2014-2024
Thion Medical (France)
2024
Centre de Recherche en Cancérologie de Lyon
2011-2024
Université de Lyon
2010-2024
Centre National de la Recherche Scientifique
2024
Transcatheter arterial chemoembolization (TACE) offers a survival benefit to patients with intermediate hepatocellular carcinoma (HCC). A widely accepted TACE regimen includes administration of doxorubicin-oil emulsion followed by gelatine sponge—conventional TACE. Recently, drug-eluting bead (DC Bead®) has been developed enhance tumor drug delivery and reduce systemic availability. This randomized trial compares conventional (cTACE) DC Bead for the treatment cirrhotic HCC. Two hundred...
A 6-month abstinence from alcohol is usually required before patients with severe alcoholic hepatitis are considered for liver transplantation. Patients whose not responding to medical therapy have a survival rate of approximately 30%. Since most deaths occur within 2 months, early transplantation attractive but controversial.We selected seven centers The had no prior episodes and scores 0.45 or higher according the Lille model (which calculates ranging 0 1, score ≥ indicating nonresponse an...
There is no established therapy for hepatitis E virus (HEV) infection. The aim of this retrospective, multicenter case series was to assess the effects ribavirin as monotherapy solid-organ transplant recipients with prolonged HEV viremia.
Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim this registry-based observational study was to explore characteristics outcomes transplants included French nationwide Registry Solid Organ Transplant Recipients with Covid-19. Covid-19 diagnosed symptomatic patients who had positive PCR assay for SARS-CoV-2 or having typical lung lesions imaging. Clinical...
It remains unclear whether physicians should accept transplantation offers for candidates with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test due to the potential risk of severe infection after initiating immunosuppressive therapy. A multicenter observational study was conducted in 19 French solid organ units. Patients on waiting list liver or kidney transplants who had nasopharyngeal swab at time were recorded. Sixty-five patients included. The recipients...
Fatty liver disease is a potential long-term complication of transplantation (LT). We therefore aimed to determine the prevalence and risk factors steatosis in large population adult post-LT patients.We evaluated clinical, biological, histological, evolutive features patients with diagnosis made at biopsy examination during follow-up. Risk were analyzed by univariate multivariate analysis.In total, 1,596 biopsies from 599 available. Recurrent was present 178 patients. A histological 131...
<h3>Background</h3> Alcohol relapse can negatively influence the outcome after liver transplantation (LT). The aim of our study was to identify factors that could be associated with recurrence harmful alcohol consumption LT. <h3>Methods</h3> A total 387 consecutive patients (23.8% women) who underwent LT for alcoholic cirrhosis in Geneva, Switzerland, and Lyon, France, between 1989 2005 were evaluated. Mean ± SD age 51.3 7.5 years. Follow-up time 61.2 47.5 months. potential it studied....
Calcineurin inhibitors (CNIs) contribute to renal dysfunction following liver transplantation. This prospective, randomized, multicenter, 6-month study (with an additional 6 months of follow-up) evaluated whether everolimus with CNI reduction or discontinuation would improve function in maintenance transplant recipients experiencing CNI-related impairment. Patients started therapy (n = 72) continued receiving standard-exposure 73). At month 6, 80% the patients who had converted discontinued...
Alcoholic liver disease (ALD) is a major indication for transplantation (LT). Recurrent alcoholic cirrhosis (RAC) after LT can occur but has not been studied. The aims of this study were to estimate the prevalence, predictive factors, and natural history RAC LT.All patients transplanted ALD between 1990 2007 in three French centers included. diagnosis was based on histological evidence or series features combined with severe relapse.Among 1,894 adult patients, 712 survived >6 months. After...
Nonalcoholic fatty liver disease (NAFLD) is a potential long-term complication after transplantation (LT) and can occur as recurrent in patients undergoing for NAFLD or de novo others. The aim of this study was to compare these 2 different entities. From cohort adult between 2000 2010, we selected all with diagnosis made during biopsy examinations post-LT follow-up; clinical, biological, histological features were compared. 91 the period: 11 cases classified NAFLD, 80 NAFLD. groups not...
Renal dysfunction is frequent in liver cirrhosis and a strong prognostic predictor of orthotopic transplantation (OLT) outcome. Therefore, an accurate evaluation the glomerular filtration rate (GFR) crucial pre-OLT patients. However, these patients plasma creatinine (Pcr) inaccurate place serum cystatine C (CystC) still debated. New GFR-predicting equations, based on standardized assays Pcr and/or CystC, have been recently recommended general population but their performance has rarely...
Abstract Background Ribavirin is currently recommended for treating chronic hepatitis E virus (HEV) infection. This retrospective European multicenter study aimed to assess the sustained virological response (SVR) in a large cohort of solid organ transplant (SOT) recipients with HEV infection treated ribavirin monotherapy (N = 255), identify predictive factors SVR, and evaluate impact RNA mutations on response. Methods Data from 255 SOT 30 centers were analyzed. was given at median dose 600...