A5026025381- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Climate Change and Health Impacts
- Global Health Care Issues
- Viral gastroenteritis research and epidemiology
- Clinical Nutrition and Gastroenterology
- Animal Virus Infections Studies
- COVID-19 and healthcare impacts
- Healthcare cost, quality, practices
- Hepatitis B Virus Studies
- Global Health Workforce Issues
- Liver physiology and pathology
- Electrolyte and hormonal disorders
- Central Venous Catheters and Hemodialysis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Healthcare Systems and Challenges
- Agriculture Sustainability and Environmental Impact
- Dysphagia Assessment and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Arrest and Resuscitation
- Gastrointestinal motility and disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
Edinburgh Royal Infirmary
2015-2024
Freeman Hospital
2021-2022
Royal Edinburgh Hospital
2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2021-2022
British Society for Haematology
2022
Creative Research Enterprises (United States)
2021-2022
Hospital Universitario Doctor Peset
2021
Universitat de València
2021
University Hospital of North Tees
2021
Newcastle University
2021
Abstract Background Ribavirin is currently recommended for treating chronic hepatitis E virus (HEV) infection. This retrospective European multicenter study aimed to assess the sustained virological response (SVR) in a large cohort of solid organ transplant (SOT) recipients with HEV infection treated ribavirin monotherapy (N = 255), identify predictive factors SVR, and evaluate impact RNA mutations on response. Methods Data from 255 SOT 30 centers were analyzed. was given at median dose 600...
Summary Background Acute liver failure is a rare and devastating clinical condition resulting from sudden loss of hepatic parenchyma metabolic function. The Scottish Liver Transplant Unit ( SLTU ) offers specialist management emergency transplantation to patients with acute across Scotland. Aim To describe temporal changes in number admissions, aetiology failure, severity disease at presentation outcomes over 22‐year period. Methods Retrospective analysis the database, including all admitted...
Background Previous studies showed low levels of circulating hepatitis E virus (HEV) in Scotland. We aimed to reassess current Scottish HEV epidemiology. Methods: Blood donor samples from five blood centres, the minipools for routine screening and liver transplant recipients were tested antibodies RNA determine seroprevalence viraemia. data compared with results previous covering 2004–08. Notified laboratory-confirmed cases (2009-16) extracted national surveillance data. Viraemic donors...
Palliative care remains suboptimal in advanced cirrhosis, part relating to a lack of evidence-based interventions. Ascites the most common cirrhosis complication resulting hospitalisation. Many patients with refractory ascites are not candidates for liver transplantation or transjugular intrahepatic portosystemic shunt, and therefore, require recurrent palliative large volume paracentesis hospital. We review available evidence on use long-term abdominal drains cirrhosis. Pending results...
Summary Background Hepatitis E virus (HEV) is the most common acute viral hepatitis in Scotland. Little known about burden of morbidity and mortality, which can be high chronic liver disease or immunocompromised states. Aims To record mortality HEV Methods Demographic, clinical laboratory data were collected retrospectively from all cases reported to virology departments across nine NHS health boards, between January 2013 2018. Results Five hundred eleven included (Mean age 62, 64% male). 58...
Healthcare services have a significant environmental cost that is contributing to the current climate crisis. Patients with liver disease are vulnerable consequences of change, but progress has been slow in making hepatology more sustainable. This article explores how change may impact on disease, we make early steps apply principals sustainable healthcare into our daily practice and identifies areas for future research priorities.
The prevalence of cirrhosis has risen significantly over recent decades and is predicted to rise further. Widespread use non-invasive testing means increasingly diagnosed at an earlier stage. Despite this, there are significant variations in outcomes patients with across the UK, areas higher levels deprivation more likely die from their liver disease. This three-part best practice guidance aims address outpatient management cirrhosis, order standardise care reduce risk progression,...
A 39-year-old female presented with a one-week history of jaundice and nausea after taking an over-the-counter herbal supplement containing ashwagandha root extract. Initial investigations revealed hepatocellular pattern liver enzyme abnormality jaundice. Investigations, including viral serology, specific autoantibodies ultrasound scan the abdomen, were unremarkable. Liver biopsy showed acute cholestatic hepatitis confluent necrosis but no features chronicity. These histopathological...
We are in a climate emergency—this is anthropogenic, and we can do something about it. An awareness of carbon footprinting essential to allow us understand address this issue, both our personal professional lives. The aim article demystify make the concept relevant gastrointestinal healthcare professional.
The prevalence of cirrhosis has risen significantly over recent decades and is predicted to rise further. Widespread use non-invasive testing means increasingly diagnosed at an earlier stage. Despite this, there are significant variations in outcomes patients with across the UK, areas higher levels deprivation more likely die from their liver disease. This three-part best practice guidance aims address outpatient management cirrhosis, order standardise care reduce risk progression,...
There are two distinct phases in the natural history of cirrhosis: compensated disease (corresponding to Child Pugh A and early B disease), where patient may be largely asymptomatic, progressing with increasing portal hypertension liver dysfunction decompensated late B-C), characterised by development overt clinical signs, including jaundice, hepatic encephalopathy (HE), ascites, renal variceal bleeding. The transition from cirrhosis (DC) heralds a watershed nature prognosis disease. DC is...
Recent fate-mapping studies in mice have provided substantial evidence that mature adult hepatocytes are a major source of new after liver injury. In other systems, integrin αvβ8 has role activating transforming growth factor (TGF)-β, potent inhibitor hepatocyte proliferation. We hypothesized depletion would increase proliferation and accelerate regeneration Using Itgb8flox/flox;Alb-Cre to deplete αvβ8, partial hepatectomy, liver-to-body weight ratio were significantly increased compared...