A5042440578- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Dialysis and Renal Disease Management
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Palliative Care and End-of-Life Issues
- Gallbladder and Bile Duct Disorders
- Nutrition and Health in Aging
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Primary Care and Health Outcomes
- Metabolism and Genetic Disorders
- Healthcare Policy and Management
- Systemic Lupus Erythematosus Research
- Nutritional Studies and Diet
- Urinary Bladder and Prostate Research
- Healthcare cost, quality, practices
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Biochemical Analysis and Sensing Techniques
- Drug Transport and Resistance Mechanisms
Leeds Teaching Hospitals NHS Trust
2008-2025
University Hospital Southampton NHS Foundation Trust
2016-2025
University of Southampton
2009-2025
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2024
Universitat Autònoma de Barcelona
2024
Institut Guttmann
2024
Auckland City Hospital
2022
Accident Compensation Corporation
2022
Ocean Power Technologies (United States)
2022
Southampton General Hospital
2006-2021
Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with history of heavy prolonged alcohol use. The short-term mortality among severe disease exceeds 30%. Prednisolone pentoxifylline are both recommended for the treatment alcoholic hepatitis, but uncertainty about their benefit persists.
There is no licensed treatment for non-alcoholic fatty liver disease (NAFLD), a condition that increases risk of chronic disease, type 2 diabetes and cardiovascular disease. We tested whether 15-18 months with docosahexaenoic acid (DHA) plus eicosapentaenoic (EPA) (Omacor/Lovaza) (4 g/day) decreased fat improved two histologically-validated fibrosis biomarker scores (primary outcomes). Patients NAFLD were randomised in double blind placebo-controlled trial [DHA+EPA(n=51), placebo(n=52)]....
Background & AimsInfections are common in patients with severe alcoholic hepatitis (SAH), but little information is available on how to predict their development or effects patients. Prednisolone advocated for treatment of SAH, can increase susceptibility infection. We compared the infection clinical outcomes treated and without prednisolone, identified risk factors SAH.MethodsWe analyzed data from 1092 enrolled a double-blind placebo-controlled trial evaluate efficacy prednisolone (40 mg...
The effect of host genetic variation on the outcome hepatitis C virus (HCV) infection and its treatment is poorly understood. chemokine receptors CCR5, CCR2, CCR3 their ligands, RANTES, MCP–1, MCP–2, MIP–1α, are involved in immune responses selective recruitment lymphocytes to liver HCV infection. We studied 20 polymorphisms within these genes investigated association with persistent carriage HCV, severity disease, hepatic inflammation, response a large European cohort. Significant...
The UK is increasingly being affected by unpredictable weather events with flooding, heatwaves and storms impacting on physical mental health livelihoods. All of these will become common as the climate crisis accelerates. Efforts made to reduce greenhouse gas (GHG) emissions are slow. Healthcare systems must meet growing demands a multi-morbid ageing population, while simultaneously reducing their environmental impact. NHS already under significant pressures currently ill-prepared deal...
<b>Background:</b> The rate of progression to cirrhosis varies among individuals chronically infected with the hepatitis C virus (HCV). Coagulation pathway activation in models hepatic fibrosis suggests variation coagulation components may influence fibrosis. We hypothesised that polymorphisms factors II and V affect HCV subjects. <b>Methods:</b> studied relationship between (calculated by dividing stage duration infection) genotypes specific genes 352 White European patients HCV. Genotyping...
<b>Introduction:</b> The rate of development liver fibrosis in hepatitis C virus (HCV) infection varies between individuals. This accounts for the variation duration progression to cirrhosis. aims this study were: (1) determine whether progresses linearly through grading scales and (2) identify factors which influence fibrosis. <b>Methods:</b> HCV infected patients who had undergone at least one biopsy were identified. Biopsies scored using modified HAI (Ishak) METAVIR systems, compared....
Abstract Background Alcoholic hepatitis is the most florid presentation of alcohol-related liver disease. In its severe form, defined by a Maddrey’s discriminant function (DF) ≥32, 28-day mortality rate approximately 35%. A number potential treatments have been subjected to clinical trials, which two, corticosteroids and pentoxifylline, may therapeutic benefit. The role controversial as trial results inconsistent, whereas pentoxifylline requires confirmation only one previous...
Summary Background Palliative care remains suboptimal in end‐stage liver disease. Aim To inform a definitive study, we assessed palliative long‐term abdominal drains disease to determine recruitment, attrition, safety/potential effectiveness, questionnaires/interview uptake/completion and make preliminary cost comparison. Methods A 12‐week feasibility nonblinded randomised controlled trial comparing large‐volume paracentesis vs refractory ascites due with fortnightly home visits for...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jul 2000A RANDOMIZED TRIAL COMPARING TRANSURETHRAL RESECTION OF THE PROSTATE, LASER THERAPY AND CONSERVATIVE TREATMENT MEN WITH SYMPTOMS ASSOCIATED BENIGN PROSTATIC ENLARGEMENT: CLasP STUDY JENNY L. DONOVAN, TIM J. PETERS, DAVID E. NEAL, SARA T. BROOKES, SANDEEP GUJRAL, K. NINAN CHACKO, MARK WRIGHT, GAIL KENNEDY, and PAUL ABRAMS DONOVANJENNY DONOVAN , PETERSTIM PETERS NEALDAVID NEAL BROOKESSARA BROOKES GUJRALSANDEEP GUJRAL...
Palliative care remains suboptimal in advanced cirrhosis, part relating to a lack of evidence-based interventions. Ascites the most common cirrhosis complication resulting hospitalisation. Many patients with refractory ascites are not candidates for liver transplantation or transjugular intrahepatic portosystemic shunt, and therefore, require recurrent palliative large volume paracentesis hospital. We review available evidence on use long-term abdominal drains cirrhosis. Pending results...
<h3>BACKGROUND/AIMS</h3> Hyaluronan (sodium hyaluronate) has been shown to confer objective and subjective improvement in patients with dry eye syndrome. This study compared the efficacy safety of a 0.1% solution hyaluronan 0.9% saline, when administered topically eye, treatment symptoms severe <h3>METHODS</h3> A randomised, double blind, crossover clinical trial which subjects were randomised receive either or applied as one two drops three four times day required. After 28 days' treatment,...
Two receptor chains, IL-10RA and IL-10RB, are known to mediate the functions of interleukin-10 (IL-10), which has been shown be involved in progression persistent hepatitis C virus (HCV) infection. Little information is available on role host genetic variation IL-10 genes outcome HCV IL-22, an homologue, shares IL-10RB chain with antiviral properties. We investigated possible polymorphisms IL-22 disease pathogenesis.This study population consisted 631 patients, recruited from several...
Background. Through migration, diversity of chronic hepatitis B virus (HBV) infection has changed, affecting disease burden and control. We describe clinical viral characteristics HBV in the United Kingdom. Methods. A total 698 individuals with were recruited from referral liver centers. Demographic, clinical, laboratory data collected. Results. Sixty-one percent patients male, 80% not born Kingdom, largest ethnicity was East/Southeast Asian (36%). Twenty-two e antigen (HBeAg) seropositive;...