A5003733406- Infectious Diseases and Mycology
- Liver Disease and Transplantation
- Mycobacterium research and diagnosis
- Analytical Chemistry and Sensors
- Liver Disease Diagnosis and Treatment
- Veterinary Pharmacology and Anesthesia
- Liver physiology and pathology
- Adipose Tissue and Metabolism
- Anesthesia and Sedative Agents
- Nanoplatforms for cancer theranostics
- Mesenchymal stem cell research
- Phagocytosis and Immune Regulation
- Actinomycetales infections and treatment
- Veterinary Equine Medical Research
- Animal Behavior and Welfare Studies
- High Altitude and Hypoxia
- Abdominal Surgery and Complications
- Acute Kidney Injury Research
- Human-Animal Interaction Studies
- Nanopore and Nanochannel Transport Studies
- Poisoning and overdose treatments
- Cellular transport and secretion
- Cassava research and cyanide
- Regulation of Appetite and Obesity
- Thermal Regulation in Medicine
University of Edinburgh
2014-2024
Roslin Institute
2019-2024
Royal Veterinary College
2023
University of London
2023
Wellcome Trust
2022
The Queen's Medical Research Institute
2013-2018
Centre for Inflammation Research
2013-2018
Medical Research Council
2015-2017
Universidade Aberta
2017
University of Nottingham
2014
Abstract Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRβ + contribute skeletal muscle cardiac via a mechanism depends on αv integrins. Mice which integrin is depleted protected from cardiotoxin laceration-induced angiotensin II-induced fibrosis. In addition, small-molecule inhibitor integrins attenuates fibrosis, even when pre-established, both muscle,...
The disposal of apoptotic bodies by professional phagocytes is crucial to effective inflammation resolution. Our ability improve the impaired a limited understanding molecular mechanisms that regulate engulfment and digestion efferocytic cargo. Macrophages are necessary for liver inflammation, fibrosis, resolution, switching their phenotype from proinflammatory restorative. Using sterile injury models, we show STAT3-IL-10-IL-6 axis positive regulator macrophage efferocytosis, survival,...
Abstract Objective —To compare survival of dogs with a congenital portosystemic shunt (CPSS) that received medical or surgical treatment. Design —Prospective cohort study. Animals —126 client-owned single CPSS. Procedures —Dogs were examined at 1 3 referral clinics, and CPSS was diagnosed in each. Dogs treatment without regard to signalment, clinical signs, results hematologic biochemical analysis. Survival data analyzed via Cox regression model. Results —During median follow-up period 579...
To compare long-term survival and quality of life data in dogs with clinical signs associated a congenital portosystemic shunt (CPSS) that underwent medical or surgical treatment.Prospective cohort study.124 client-owned CPSS.Dogs received treatment without regard to signalment, signs, clinicopathologic results. Survival were analyzed Cox regression model. Quality information, obtained from owner questionnaires, included frequency CPSS-associated (from which score was derived), whether...
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating selectively increasing the dose delivered to hypoxic regions. Here we describe miniature implantable sensor for real-time monitoring tissue oxygenation that enable this novel treatment approach implemented. The uses solid-state electrochemical cell was microfabricated at wafer level on silicon substrate, includes an integrated reference electrode electrolyte...
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or Batten is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the gene encoding soluble enzyme palmitoyl-protein thioesterase 1 (PPT1). Therapies for disease have proven challenging because of aggressive course and need to treat widespread areas brain spinal cord. Indeed, therapy has less effective than other similar deficiencies. We therefore tested efficacy replacement (ERT) by...
In vitro cell line and in vivo murine models have historically dominated pre-clinical cancer research. These can be expensive time consuming lead to only a small percentage of anti-cancer drugs gaining licence for human use. Large animal that reflect disease high translational value; these used overcome current research limitations through the integration drug development techniques with surgical procedures anaesthetic protocols, along emerging fields such as implantable medical devices....
Ovine pulmonary adenocarcinoma (OPA) is an infectious, neoplastic lung disease of sheep that causes significant animal welfare and economic issues throughout the world. Understanding OPA pathogenesis key to developing tools control its impact. Central this need availability model systems can monitor track events after Jaagsiekte retrovirus (JSRV) infection. Here, we report development experimentally induced intended for purpose. Using three different viral dose groups (low, intermediate...
Recent fate-mapping studies in mice have provided substantial evidence that mature adult hepatocytes are a major source of new after liver injury. In other systems, integrin αvβ8 has role activating transforming growth factor (TGF)-β, potent inhibitor hepatocyte proliferation. We hypothesized depletion would increase proliferation and accelerate regeneration Using Itgb8flox/flox;Alb-Cre to deplete αvβ8, partial hepatectomy, liver-to-body weight ratio were significantly increased compared...
Background: Dicobalt edetate and hydroxocobalamin are widely used to treat hydrogen cyanide poisoning. However, comparative quantitative efficacy data lacking. Although post-exposure treatment is typical, it may be possible administer these antidotes before exposure first attenders entering a known site of release, as supplementary protection their personal protective equipment.Methods: We established an anaesthetised Gottingen minipig model lethal bolus potassium (KCN) injection simulate...
Pigs are commonly stunned pre-slaughter by exposure to carbon dioxide (CO 2 ), but this approach is associated with significant welfare concerns. Hypobaric hypoxia, achieved gradual decompression (also known as Low Atmospheric Pressure Stunning or LAPS) may be an alternative, allowing the retention of friendly handling approaches and group stunning. Although validated in poultry, feasibility consequences for pigs unknown. Here, we characterize pathological changes 60 resulting from a range...
Abstract This case report describes the premature and unanticipated recovery of a bull from general anaesthesia for penile surgery. Retrospective review revealed: (i) elements management that contributed to this critical event; (ii) other measures allowed prompt control, thus minimising risk subject personnel. The highlights challenges monitoring depth in large ruminants illustrates non‐surgical stimuli such as hoisting can be equally, if not more, stimulating than surgery itself. Finally,...
To investigate the association between body mass and hypotension during general anaesthesia in dogs undergoing surgical diagnostic procedures within a referral hospital.Retrospective evaluation of anaesthetic records 1789 was performed. Data on signalment, protocol physiological variables, including mean arterial pressure, were collected. A multivariable generalised linear model used to identify associations explanatory mass, hypotension.In population studied, increasing (per 10 kg)...
Alternatives to carbon dioxide (CO 2 ) stunning for the commercial slaughter of pigs are urgently needed because there is robust evidence that exposing hypercapnic environments associated with pain, fear, and distress. Hypobaric hypoxia (via gradual decompression, also known as Low Atmospheric Pressure Stunning or LAPS) has been validated in poultry a humane option, but its potential improve welfare at unknown. We investigated hypobaric reliably elicit non-recovery state anesthetized...
Pigs are used to model humans in gastrointestinal (GI) studies because of their comparable size, physiology and behaviour: both monogastric omnivores. A porcine surgical for testing novel, tethered ultrasound capsule endoscopes (USCE) requires a clean, motile small intestine. Recommendations human GI tract preparation before the mechanically similar process video endoscopy describe using oral purgatives, while high-carbohydrate drinks recommended colorectal surgery. Reports pigs exist but...