A5027973247- Cardiac Arrest and Resuscitation
- Infectious Diseases and Mycology
- Mycobacterium research and diagnosis
- Analytical Chemistry and Sensors
- Veterinary Pharmacology and Anesthesia
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Ischemia and Reperfusion
- Lysosomal Storage Disorders Research
- Body Composition Measurement Techniques
- Nanoplatforms for cancer theranostics
- Gastroesophageal reflux and treatments
- Actinomycetales infections and treatment
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Glycogen Storage Diseases and Myoclonus
- Optical Imaging and Spectroscopy Techniques
- Ion channel regulation and function
- Organ Transplantation Techniques and Outcomes
- Myxozoan Parasites in Aquatic Species
- Wireless Body Area Networks
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Spectroscopy and Chemometric Analyses
- Hemostasis and retained surgical items
Roslin Institute
2017-2024
University of Edinburgh
2012-2024
Wellcome Trust
2017-2021
Scotland's Rural College
2011
This paper describes the design, fabrication, packaging, and performance characterization of a conformal helix antenna created on outside 10 mm × 30 capsule endoscope designed to operate at carrier frequency 433 MHz within human tissue. Wireless data transfer was established between integrated system an external receiver. The telemetry tested tissue phantom in vivo porcine models. Two different types transmission modes were tested. first mode, replicating normal operating conditions, used...
Abstract The neuronal ceroid lipofuscinoses (NCLs) are a group of devastating monogenetic lysosomal disorders that affect children and young adults with no cure or effective treatment currently available. One the more severe infantile forms disease (INCL CLN1 disease) is due to mutations in palmitoyl-protein thioesterase 1 ( PPT1 ) gene severely reduces child’s lifespan approximately 9 years age. In order better translate human condition than possible mice, we sought produce large animal...
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating selectively increasing the dose delivered to hypoxic regions. Here we describe miniature implantable sensor for real-time monitoring tissue oxygenation that enable this novel treatment approach implemented. The uses solid-state electrochemical cell was microfabricated at wafer level on silicon substrate, includes an integrated reference electrode electrolyte...
Background: Colchicine poisoning is commonly lethal. Colchicine-specific Fab fragments increase rat urinary colchicine clearance and have been associated with a good outcome in one patient. We aimed to develop porcine model of toxicity study the pharmacokinetics efficacy ovine Fab.Methods: A Göttingen minipig critical care was established serial blood samples taken for pharmacokinetics, clinical chemistry, haematology. Animals were euthanised when mean arterial pressure fell below 45 mmHg...
Clinical endoscopy and colonoscopy are commonly used to investigate diagnose disorders in the upper gastrointestinal tract colon, respectively. However, examination of anatomically remote small bowel with conventional is challenging. This advances miniaturization led development video capsule (VCE) allow a noninvasive manner. Available since 2001, current endoscopes limited viewing mucosal surface only due their reliance on optical imaging. To overcome this limitation submucosal imaging,...
Question In healthy adult female non-pregnant sheep undergoing general anaesthesia for research studies does the inclusion of intravenous medetomidine as part anaesthetic protocol cause hypoxaemia? Clinical bottom line The category question was: Treatment. number and type study designs that were critically appraised were: Four papers available critical appraisal. quality evidence is weak. There four experimental studies; three which cross-over one was run in parallel with primary orthopaedic...
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or Batten is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the gene encoding soluble enzyme palmitoyl-protein thioesterase 1 (PPT1). Therapies for disease have proven challenging because of aggressive course and need to treat widespread areas brain spinal cord. Indeed, therapy has less effective than other similar deficiencies. We therefore tested efficacy replacement (ERT) by...
Ovine pulmonary adenocarcinoma (OPA) is an infectious, neoplastic lung disease of sheep that causes significant animal welfare and economic issues throughout the world. Understanding OPA pathogenesis key to developing tools control its impact. Central this need availability model systems can monitor track events after Jaagsiekte retrovirus (JSRV) infection. Here, we report development experimentally induced intended for purpose. Using three different viral dose groups (low, intermediate...
In vitro cell line and in vivo murine models have historically dominated pre-clinical cancer research. These can be expensive time consuming lead to only a small percentage of anti-cancer drugs gaining licence for human use. Large animal that reflect disease high translational value; these used overcome current research limitations through the integration drug development techniques with surgical procedures anaesthetic protocols, along emerging fields such as implantable medical devices....
Background and Aims Liver graft quality is evaluated by visual inspection prior to transplantation, a process highly dependent on the surgeon’s experience. We present an objective, noninvasive, quantitative way of assessing liver in real time using Raman spectroscopy, laser‐based tool for analyzing biomolecular composition. Approach Results A porcine model donation after circulatory death (DCD) with normothermic regional perfusion (NRP) allowed assessment premortem, during warm ischemia (WI)...
Background: Dicobalt edetate and hydroxocobalamin are widely used to treat hydrogen cyanide poisoning. However, comparative quantitative efficacy data lacking. Although post-exposure treatment is typical, it may be possible administer these antidotes before exposure first attenders entering a known site of release, as supplementary protection their personal protective equipment.Methods: We established an anaesthetised Gottingen minipig model lethal bolus potassium (KCN) injection simulate...
High fractional concentrations of inspired oxygen (FiO(2)) delivered over prolonged periods produce characteristic histological changes in the lungs and airway exposed animals. Modern medical anaesthetic machines are adapted to deliver air (FiO(2)=0.21) for purpose reducing FiO(2); designed veterinary market have not been so adapted. Two inexpensive modifications that allow be added gas flow from described. The advantages disadvantages each modification discussed.
Pigs are used to model humans in gastrointestinal (GI) studies because of their comparable size, physiology and behaviour: both monogastric omnivores. A porcine surgical for testing novel, tethered ultrasound capsule endoscopes (USCE) requires a clean, motile small intestine. Recommendations human GI tract preparation before the mechanically similar process video endoscopy describe using oral purgatives, while high-carbohydrate drinks recommended colorectal surgery. Reports pigs exist but...
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating selectively increasing the dose delivered to hypoxic regions. Here we describe miniature implantable sensor for real-time monitoring tissue oxygenation that enable this novel treatment approach implemented. The uses solid-state electrochemical cell was microfabricated at wafer level on silicon substrate, includes an integrated reference electrode electrolyte...
<h3>Purpose</h3> When attempting defibrillation in an out-of-hospital paediatric patient, the use of a reduced energy is currently recommended resuscitation guidelines due to concerns surrounding potential myocardial damage. The purpose this pilot study was investigate 1st shock success two different automated external defibrillator (AED) protocols and observe resulting levels damage model cardiac arrest. <h3>Method</h3> A total six piglets (10–25 kg) were anaesthetised, instrumented...
Objective: When attempting defibrillation in an out-of-hospital pediatric patient, the use of a reduced energy is recommended by resuscitation guidelines due to concerns surrounding potential myocardial damage. This study investigated effectiveness (first shock success) and safety (myocardial damage) using adult energies model cardiac arrest. Methods: Twelve piglets (9.5-25.5 kg; typical weight range 1 8 year old children) were anaesthetized VF was electrically induced. After 15 seconds...
Purpose: Previous studies from our group demonstrated that chest compression (CCs) applied according to depth feedback produced potentially fatal intrathoracic damage in paediatric porcine models. The objective of this study is assess if CPR an automated external defibrillator (AED) using the impedance cardiogram (ICG) can guide CC application achieve high