A5087509755- Melanoma and MAPK Pathways
- Protein Degradation and Inhibitors
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Advanced Breast Cancer Therapies
- Zoonotic diseases and public health
- Animal Disease Management and Epidemiology
- Child and Adolescent Health
- Viral gastroenteritis research and epidemiology
- Genetic and phenotypic traits in livestock
- PI3K/AKT/mTOR signaling in cancer
- Pediatric health and respiratory diseases
- Health disparities and outcomes
- Global Cancer Incidence and Screening
- Vector-Borne Animal Diseases
- COVID-19 epidemiological studies
- Health Promotion and Cardiovascular Prevention
- Immune Response and Inflammation
- Insect and Pesticide Research
- Primary Care and Health Outcomes
- Obesity and Health Practices
- Wnt/β-catenin signaling in development and cancer
- Prion Diseases and Protein Misfolding
- Escherichia coli research studies
- Breast Implant and Reconstruction
Roslin Institute
2015-2025
University of Edinburgh
2015-2025
University Hospital Southampton NHS Foundation Trust
2024
Bioscience Research
2023
Medawar Building for Pathogen Research
2021
University of Oxford
2021
Edinburgh College
2021
Genomics (United Kingdom)
2018
National Health Service Scotland
2002-2017
AstraZeneca (United Kingdom)
2016
The specialisation of mammalian cells in time and space requires genes associated with specific pathways functions to be co-ordinately expressed. Here we have combined a large number publically available microarray datasets derived from human primary analysed correlation graphs these data. Using the network analysis tool BioLayout Express3D identify robust co-associations expressed wide variety cell lineages. We discuss biological significance associations, particular coexpression key...
The main aim of this pilot study was to test the 'construct' validity Euroqol, a new generic health status instrument which consists questionnaire and visual analogue scale. Its ability measure both current change in assessed 55 patients with RA. Euroqol scales showed significant clinically relevant correlations other condition-specific instruments measuring loss function, joint pain, tenderness mood; these symptoms as measured by also predictive scores. Either component provide an index...
Abstract Both natural infection with SARS-CoV-2 and immunization a number of vaccines induce protective immunity. However, the ability such immune responses to recognize therefore protect against emerging variants is matter increasing importance. Such concern (VOC) include isolates lineage B1.1.7, first identified in UK, B1.351, South Africa. Our data confirm that VOC, particularly those substitutions at residues 484 417 escape neutralization by antibodies directed ACE2-binding Class 1...
Inequalities in coronary heart disease mortality by country of birth are large and poorly understood. However, these data misclassify UK-born minority ethnic groups provide little detail on whether excess risk is due to increased incidence, poorer survival or both.Retrospective cohort study.General resident population Scotland.All those residing Scotland during the 2001 Census were eligible for inclusion: 2 972 120 people included analysis. The number still at end study 2008 not known.As...
The distribution, cell tropism, and cytopathology in vivo of human immunodeficiency virus (HIV) was investigated postmortem tissue samples from a series HIV-infected individuals who died either complications associated with AIDS or for unrelated reasons while they were asymptomatic. Proviral sequences detected at high copy number lymphoid both presymptomatic patients AIDS, whereas significant infection nonlymphoid such as that brains, spinal cords, lungs confined to those AIDS. V3 loop...
niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Different regions of the small ruminant lung exhibit variable susceptibility to specific pathologies. Such may be reflected in regional radiomic features extracted from computed tomography (CT) images. In this study, we investigated whether region-specific variation exists ovine lungs and these remain stable over time. Thoracic CT image datasets 30 young adult sheep were subject an segmentation protocol directed at partitioning into individual lobar sub-lobar segments for feature analysis....
Radiomic feature (RF) analysis of computed tomography (CT) images may aid the diagnosis and staging ovine pulmonary adenocarcinoma (OPA). We assessed RF characteristics OPA tumours in JSRV-infected sheep compared to non-tumour lung tissues, examined their stability over time, analysed variations nascent tumour field (NTF) margin (NTmF). In monthly CT scans, tissues were automatically segmented by density, manually segmented. RFs calculated for each imaging session, selected according...
Abstract Both natural infection with SARS-CoV-2 and immunization vaccines induce protective immunity. However, the extent to which such immune responses protect against emerging variants is of increasing importance. Such concern (VOC) include isolates lineage B.1.1.7, first identified in UK, B.1.351, South Africa. Our data confirm that VOC, particularly those substitutions at residues 484 417, escape neutralization by antibodies directed ACE2-binding Class 1 adjacent 2 epitopes but are...
Ethnic variations in stroke require more European studies, especially as differences are reportedly large. We created a retrospective cohort study of 4.65 million people Scotland linking ethnicity from the census and incidence mortality NHS databases. Rate ratios using direct age standardization risk were calculated, latter to model influence educational qualification Poisson regression model. Age-adjusted rate varied little, compared White Scottish group (reference value 100) 95% CIs...
European research on ethnic variations in cardiovascular disease has mostly examined mortality endpoints using country of birth as a proxy for ethnicity. We report chest pain and angina by group. Retrospective cohort linking the Census 2001 Scotland (providing 14 group categories) hospital discharge/community deaths data. Directly age-standardized rates rate ratios were calculated. Risk adjusted age then highest educational qualification individual Poisson regression. Ratios multiplied 100...
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic diarrhea and potentially fatal renal failure in humans. Ruminants are considered to be the primary reservoir for human infection. Vaccines that reduce shedding cattle only partially protective, their underlying protective mechanisms unknown. Studies investigating response of colonization generally focus on humoral immunity, leaving role cellular immunity unclear. To inform future vaccine development, we studied immune...
Non-small-cell lung cancer is the leading cause of death worldwide and comprised several histological subtypes, two most common being adenocarcinoma (AC) squamous cell carcinoma (SCC). Targeted therapies have successfully improved response rates in patients with AC tumors. However, majority SCC tumors lack specific targetable mutations, making development new treatment paradigms for this disease challenging. In present study, we used iterative non-negative matrix factorization, an unbiased...
Abstract Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides. Although this biochemical defect reconfigures metabolism and leads to elevated levels breakdown product urea, it remains unclear exactly how loss HPRT activity disrupts brain function. As rat preferred rodent experimental model studying neurobiology...
Detection of antibody to recombinant proteins derived from hepatitis C virus (HCV) genotype 1 represents the principal method for diagnosis HCV infection. A was developed quantifying reactivity in two third-generation enzyme immunoassays (Ortho EIA 3.0 and Murex VK48), influence viraemia, genotype, host factors such as age, gender, risk group upon levels were investigated a consecutive series 117 anti-HCV-positive volunteer blood donors. Viraemic donors (as assessed by polymerase chain...
Summary The influence of weather on deep venous thrombosis (DVT) incidence remains controversial. We aimed to characterize the temporal association between DVT and meteorological variables including atmospheric pressure. Data relating hospital admissions with in Scotland were collected retrospectively for a 20 year period which corresponding recordings available. Weather calculated as weighted daily averages adjust variations population density. Seasonal variation short-term effects relative...
<h3>Objective</h3> Ethnic variations in heart failure are, apparently, large (eg, up to threefold South Asians compared with White populations Leicestershire, UK) but data are limited and conflicting. The incidence of first occurrence hospitalisation or death by ethnic group Scotland was studied. <h3>Design, setting, outcomes</h3> A retrospective cohort study developed 4.65 million people using non-disclosive, computerised methods linking the Scottish 2001 census (providing group) community...
Variant Creutzfeldt-Jakob disease (vCJD) is a human prion resulting from zoonotic transmission of bovine spongiform encephalopathy (BSE). Documented cases vCJD by blood transfusion necessitate on-going risk reduction measures to protect supplies, such as leucodepletion (removal white cells, WBCs). This study set out determine the risks labile components (red platelets, plasma) commonly used in medicine, and effectiveness preventing infection, using BSE-infected sheep model. All were capable...