A5039311772- Ginger and Zingiberaceae research
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Plant Reproductive Biology
- Analytical Chemistry and Chromatography
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Pesticide Residue Analysis and Safety
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Esophageal and GI Pathology
- Redox biology and oxidative stress
- Genomics and Phylogenetic Studies
- Cancer Mechanisms and Therapy
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Dermatologic Treatments and Research
- Plant-Microbe Interactions and Immunity
- ATP Synthase and ATPases Research
Chongqing University of Arts and Sciences
2021-2024
Guangdong University of Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
Huazhong University of Science and Technology
2008-2021
Tongji Hospital
2008-2021
Wuhan Academy of Agricultural Sciences
2020
Fuling Center Hospital of Chongqing
2020
Chongqing Medical University
2020
Shanghai Jiao Tong University
2020
Hunan University of Traditional Chinese Medicine
2020
nificantly downregulated in multiple gastric cancer cell lines.Forced miR-143-5p and miR-143-3p expression cells produced a profound cytotoxic effect.MiR-145-5p transfection into resulted greater growth inhibitory effect (61.23% ± 3.16% vs 46.58% 4.28%, P < 0.05 the MKN-1 line) higher apoptosis rate (28.74% 1.93% 22.13% 3.31%, than transfection.Further analysis indicated that COX-2 was potently suppressed by but not miR-143-3p.The activity of luciferase reporter construct contained...
Abstract Background AP2/ERF transcription factors (TFs) constitute one of the largest TF families in plants, which play crucial roles plant metabolism, growth, and development as well biotic abiotic stresses responses. Although family has been thoroughly identified many species several TFs have functionally characterized, little is known about this ginger ( Zingiber officinale Roscoe), an important affinal drug diet vegetable. Recent completion genome sequencing provides opportunity to...
Lung cancer is the leading cause of cancer‑associated mortality worldwide. Cisplatin (DDP) a first‑line chemotherapeutic drug for treatment lung cancer; however, majority patients develop resistance to DDP. P‑glycoprotein (P‑gp), also referred as multidrug (MDR) protein 1, associated with an MDR phenotype, which results in failure chemotherapy; thus, identifying effective pump inhibitors may improve outcomes who treatment. Hesperetin derivative hesperidin, extracted from tangerine peel and...
Nonalcoholic fatty liver disease (NAFLD) is a kind of lipid synthesis and degradation imbalance related with metabolic syndrome. Celecoxib shows the function ameliorating NAFLD, but underlying mechanisms remain unknown. Here, we discuss possible celecoxib alleviating NAFLD by restoring autophagic flux. Lipids were accumulated in L02 cells treated palmitate as well SD rats fed high-fat diet. Western blot showed that LC3 II/I was higher p62 lower on early stage steatosis while late both them...
Abstract Background The optimal sampling techniques for endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) remain unclear and have not been standardized. aim of this study was to compare the wet-suction dry-suction solid lesions in pancreas, mediastinum, abdomen. Methods This a multicenter, crossover, randomized controlled trial with order techniques. 296 consecutive patients underwent EUS-FNA 22G needles were ratio 1:1 into two separate groups that received different order....
DNA transposon piggyBac (PB) is a newly established mutagen for large-scale mutagenesis in mice. We have designed and implemented an integrated database system called PBmice (PB Mutagenesis Information CEnter) storing, retrieving displaying the information derived from PB insertions (INSERTs) mouse genome. This centered on INSERTs with including their genomic locations flanking sequences, expression levels of hit genes, patterns trapped genes if trapping vector was used. It also archives...
Background: Endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA) is a novel modality in the treatment of solid tumours. The aim study to evaluate technical feasibility, safety and efficacy multiple-round EUS-RFA with low power for unresectable pancreatic cancer. Methods: We conducted retrospective analysis eleven cases cancer who underwent between November 2013 2018. For each lesion, RITA 1500X generator was used deliver 5‒10 watts 90 seconds, repeatedly. Eight same procedure one...
Amyloid β (Aβ) peptide aggregating to form a neurotoxic plaque, leading cognitive deficits, is believed be one of the plausible mechanisms for Alzheimer's disease (AD). Inhibiting Aβ aggregation supposed offer neuroprotective effect ameliorate AD. A previous report has shown that SLM, carbazole-based fluorophore, binds inhibit aggregation. However, it not entirely clear whether inhibition alone would lead anticipated effects. In current study, we intended examine protective action SLM...
Linear endoscopic ultrasonography (EUS) allows the visualization, identification, and characterization of extent lesions gastrointestinal (GI) tract adjacent structures. EUS-guided fine-needle aspiration (EUS-FNA) facilitates a more accurate diagnosis mediastinal, intra-abdominal, pancreatic through collection cytological material under direct visualization. Recent reports suggest that histological samples can be obtained by EUS-FNA with reverse, bevel-tipped needle (the ProCore needle) to...
Abstract Background MicroRNAs (miRNAs) are endogenous, non-coding small functional RNAs that govern the post-transcriptional regulatory system of gene expression and control growth development plants. Ginger is an herb well-known for its flavor medicinal properties. The genes involved in ginger rhizome secondary metabolism have been discovered, but genome-wide identification miRNAs their overall profiles targets during largely unknown. In this study, we used BGISEQ-500 technology to perform...
Heavy metal and harmful element contamination are frequently reported in Chinese herbal medicines (CHMs), roots rhizomes parts showed a higher content than other parts. To investigate the residue level assess potential human health risk of heavy metals elements rhizomes, 720 batches sample representing 20 species herbs from different sources were collected. The Pb, Cd, As, Hg, Cu digests was determined using ICP-MS. chronic hazard index estimate based on non-cancer quotient (HQ) applied for...
Abstract Water stress and hypersensitive response (WHy) domain is typically found as a component of atypical late embryogenesis abundant (LEA) proteins closely associated with resistance to multiple stresses in numerous organisms. Several putative LEA have been identified Deinococcus bacteria; however their precise function remains unclear. This work reports the characterization -specific gene encoding novel WHy domain-containing hydrophobic LEA5C protein (named DrwH) D . radiodurans R1. The...
Histopathological examination is pivotal in diagnosing autoimmune pancreatitis (AIP). The usefulness of EUS-guided fine needle aspiration (EUS-FNA) AIP remains controversial worldwide. authors conducted this study to evaluate the efficacy EUS-FNA for diagnosis using a 22-gauge needle.Between January 2013 and May 2017, 37 patients had imaging studies suggestive at Tongji Hospital, 27 them were enrolled study. Tissue specimens acquired through analyzed periductal lymphoplasmacytic infiltrate...
Several suction techniques have been developed recently to enhance tissue acquisition when sampling solid lesions using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The aim of this study is determine whether a new modified wet technique (MWST) compared with the conventional dry (DRST) shall present better outcomes respect diagnostic yield and specimen quality in intra-abdomen mediastinum. This single-blind, randomized, controlled, superiority trial conducted at four large...