A5101535929- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Stroke Rehabilitation and Recovery
- Cardiac Imaging and Diagnostics
- Retinal Imaging and Analysis
- Lipoproteins and Cardiovascular Health
- COVID-19 diagnosis using AI
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Gout, Hyperuricemia, Uric Acid
- Adipokines, Inflammation, and Metabolic Diseases
- Alcohol Consumption and Health Effects
- Radiomics and Machine Learning in Medical Imaging
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
South China Sea Institute Of Oceanology
2025
Institute of Oceanology
2025
Chinese Academy of Sciences
2023-2025
Shanghai First People's Hospital
2020-2025
Shanghai Jiao Tong University
2020-2025
Capital Medical University
2011-2024
Zhejiang Hospital
2023-2024
Renji Hospital
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Background— The American Heart Association Committee recently developed definitions of “ideal,” “intermediate,” and “poor” cardiovascular health based on 7 disease (CVD) risk factors or behaviors. This study evaluated the prevalence “ideal” metrics from June 2006 to October 2007 in Kailuan cohort (n=101 510; age 18–98 years) northern China its relationship with 4-year CVD incidence. Methods Results— We used Cox proportional hazards regression calculate hazard ratios 95% confidence intervals...
Background As a leading cause of severe disability and death, stroke places an enormous burden on the health care system in China. There are limited data pattern current medical practice quality delivery for patients at national level. Aim The nation-wide prospective registry, China National Stroke Registry, will be considered with regard to its design, progress, geographic coverage, hospital patient characteristics. Methods Between September 2007 August 2008, Registry recruited consecutive...
Previous studies showed an inverse association between ideal cardiovascular health (CVH) metrics and the total risk of diseases stroke. This study aimed to investigate relationship CVH risks ischemic hemorrhagic stroke, respectively.We collected information on 7 (including smoking status, body mass index, dietary intake, physical activity, blood pressure, cholesterol, fasting glucose) among 91 698 participants from Kailuan study, China (72 826 men 18 872 women ages 98 years), free myocardial...
Background and Purpose— Little is known about intravenous recombinant tissue plasminogen activator (rtPA) use in China. By accessing the Chinese National Stroke Registry (CNSR), rate of rtPA was reviewed. We specifically examined issues prehospital in-emergency department delay compared them with published data from developed countries. Methods— Funded by government, CNSR only nationwide stroke registry that includes 132 urban hospitals. All patients eligible for were included analysis. then...
Background and Purpose— Diabetes mellitus (DM) is an independent risk factor for ischemic stroke. However, controversy exists with regard to the impact of DM on prognosis after stroke in Chinese population. We investigated associations between death, dependency, recurrence patients onset a nationwide, prospective registry, China National Stroke Registry. Methods— The Registry consecutively recruited hospitalized acute 2007 2008 who were prospectively followed up clinical functional outcomes...
Abstract Sex differences are widely observed under various circumstances ranging from physiological processes to therapeutic responses, and a myriad of sex-biased genes have been identified. In recent years, transcriptomic datasets microRNAs (miRNAs), an important class non-coding RNAs, become increasingly accessible. However, comprehensive analysis sex difference in miRNA expression has not performed. Here, we identified the differentially-expressed miRNAs between males females by examining...
Suboptimal health status (SHS) is a physical state between and disease, characterized by the perception of complaints, general weakness, chronic fatigue low energy levels. SHS proposed ancient concept traditional Chinese medicine (TCM) from perspective preservative, predictive personalized (precision) medicine. We previously created suboptimal questionnaire 25 (SHSQ-25), novel instrument to measure SHS, validated in various populations. SHSQ-25 thus affords window opportunity for early...
Abstract We collected data from Kailuan cohort study 2006 to 2011 examine whether short-term effects of ambient temperature on heart rate (HR) and blood pressure (BP) are non-linear or linear, their potential modifying factors. The HR, BP individual information, including basic characteristics, life style, socio-economic characteristics other were for each participant. Daily mean relative humidity collected. A regression model was used evaluate associations with HR BP, a function...
Aging in an individual refers to the temporal change, mostly decline, body’s ability meet physiological demands. Biological age (BA) is a biomarker of chronological aging and can be used stratify populations predict certain age-related chronic diseases. BA predicted from biomedical features such as brain MRI, retinal, or facial images, but inherent heterogeneity process limits usefulness body systems. In this paper, we developed multimodal Transformer–based architecture with cross-attention...
Objective The objective of this study was to explore the association between adiposity and risk incident stroke among men women. Methods We studied relationship 94,744 participants (18–98 years old) in Kailuan study. During a follow-up 4 years, 1,547 ischemic or hemorrhagic strokes were recorded. Measurements included body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), waist-to-height (WHtR). Hazard ratios (HRs) with 95% confidence intervals (CIs) calculated from Cox...
Glycosylation significantly affects protein structure and function thus participates in multiple physiologic pathologic processes. Studies demonstrated that immunoglobulin G (IgG) N-glycosylation associates with the risk factors of ischemic stroke (IS), such as aging, obesity, dyslipidemia, type 2 diabetes, hypertension. The study aimed to investigate association between IgG IS a Chinese population. glycome composition patients (n = 78) cerebral arterial stenosis (CAS) 75) controls 77) were...
Immune and inflammation dysregulation have been associated with the aging process contribute to age-related disorders, but underlying mechanism remains elusive. Here, we employed late-generation Terc knockout (Terc-/-) mice investigate impact of telomere dysfunction on host defense function innate immune cells. Terc-/- displayed exaggerated lung increased mortality upon respiratory staphylococcal infection, although their pathogen-clearing capacity was uncompromised. Mechanistically, found...
Suboptimal health status (SHS) is a physical state between and illness, previous studies suggested that SHS associated with majority components of cardiovascular metrics defined by American Heart Association (AHA). We investigated the association in cross-sectional analysis China suboptimal cohort study (COACS) consisting 4313 participants (60.30% women) aged from 18 to 65 years old. The respective prevalence 7.10%, 9.18%, 10.04% 10.62% first, second, third fourth quartiles ideal (CVH) (P...
Rationale: PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1α) represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate expression as a therapy, for instance, causing cardiomyopathy. Objective: To determine whether fine-tuning of is essential cardiac homeostasis in context-dependent manner. Methods Results: Moderate cardiac-specific overexpression through ROSA26 locus knock-in strategy was...
Non-alcoholic fatty liver disease (NAFLD) is a common chronic metabolic worldwide. Up to 70%-80% of patients with NAFLD were obese, especially abdominal obesity. Many indicators obesity have been reported, including waist circumference (WC), visceral index (VAI), lipid accumulation (LAP), and Chinese VAI (CVAI). However, few studies investigated the associations between these indices NAFLD. This present study aims explore A total 7,238 participants involved in cross-sectional study, 1,584...
Abstract Aim To investigate the potential causal relationship between non‐alcoholic fatty liver disease (NAFLD) and complications in type 1 diabetes (T1D) 2 (T2D). Materials Methods Two‐sample Mendelian randomization (MR) analysis was conducted to appraise after controlling for confounding factors. Genetic instrument variables NAFLD surrogated by chronically elevated serum alanine transferase were derived from a recent genome‐wide association study. Diabetes‐related complications, including...
Introduction The study aimed to explore the association of serum 25(OH)D 3 and hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients determine whether effect vitamin D (VD) is mediated by activation peroxisome proliferator-activated receptor α (PPARα) pathway. Methods contained a case-control study, vivo vitro experiments. A was conducted compare parameters between NAFLD controls evaluate NAFLD. In male Wistar rats were randomly divided into control model groups, fed...
Background Studies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD the of recurrent stroke year remains unclear. This study was to investigate 2 weeks following a could increase Methods and Results multi-centered prospective cohort study. A total 2306 patients with acute were enrolled in our diagnosed according criteria set by Diagnostic Statistical Manual Mental Disorders, fourth edition (DSM-IV). The outcomes followed up via face-to-face or...