A5102872116- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Corneal surgery and disorders
- Impact of Light on Environment and Health
- Single-cell and spatial transcriptomics
- Ophthalmology and Visual Impairment Studies
- SARS-CoV-2 and COVID-19 Research
- Genetics, Aging, and Longevity in Model Organisms
- Molecular Biology Techniques and Applications
Center for Life Sciences
2019-2023
Peking University
2019-2023
The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same the severe acute respiratory syndrome (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely be infected than females account for majority of severely ill and fatality, which also bias people older 60 years or with metabolic cardiovascular diseases. Here by analyzing GTEx other public data...
Quantifying aging rate is important for evaluating age-associated decline and mortality. A blood single-cell RNA sequencing dataset seven supercentenarians (SCs) was recently generated. Here, we generate a reference 28-sample cohort to compute level clock determine the biological age of SCs. Our model placed SCs at between 80.43 102.67 years. Compared model-expected trajectory, display increased naive CD8+ T cells, decreased cytotoxic memory CD4+ megakaryocytes. As most prominent molecular...
Wearable smart watches provide large amount of real-time data on the environmental state users and are useful to determine risk factors for onset progression myopia. We aim evaluate efficacy machine learning algorithm in differentiating indoor outdoor locations as collected by use watches.Real time luminance, ultraviolet light levels number steps obtained with from dataset A: 12 adults 8 scenes manually recorded true locations. 70% was considered training set support vector (SVM) generated...