A5054440760- Pancreatitis Pathology and Treatment
- Gut microbiota and health
- Dermatologic Treatments and Research
- Endometriosis Research and Treatment
- Wound Healing and Treatments
- Pancreatic function and diabetes
- Burn Injury Management and Outcomes
- Tryptophan and brain disorders
- Cutaneous Melanoma Detection and Management
- Pancreatic and Hepatic Oncology Research
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Plant tissue culture and regeneration
- Photonic and Optical Devices
- Organic Light-Emitting Diodes Research
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- Paleontology and Stratigraphy of Fossils
- Immunotherapy and Immune Responses
- melanin and skin pigmentation
- Cancer Immunotherapy and Biomarkers
- Spondyloarthritis Studies and Treatments
- Calcium signaling and nucleotide metabolism
- Galectins and Cancer Biology
- NF-κB Signaling Pathways
Wuhan University of Science and Technology
2025
Harvard University
2025
Massachusetts General Hospital
2025
Beijing Tongren Hospital
2025
Capital Medical University
2025
Xiamen University of Technology
2024
Xiamen University
2019-2024
First Affiliated Hospital of Xiamen University
2021-2024
Longgang Central Hospital
2023-2024
Xuzhou Medical College
2021-2023
Abstract Dendritic cells play a key role in processing and presenting antigens to naïve T prime adaptive immunity. Circadian rhythms are known regulate many aspects of immunity; however, the circadian dendritic cell function is still unclear. Here, we show greater responses when mice immunised middle their rest versus active phase. We find rhythm antigen that correlates with both mitochondrial morphology metabolism, dependent on molecular clock gene, Bmal1 . Using Mdivi-1, compound promotes...
Immune and inflammation dysregulation have been associated with the aging process contribute to age-related disorders, but underlying mechanism remains elusive. Here, we employed late-generation Terc knockout (Terc-/-) mice investigate impact of telomere dysfunction on host defense function innate immune cells. Terc-/- displayed exaggerated lung increased mortality upon respiratory staphylococcal infection, although their pathogen-clearing capacity was uncompromised. Mechanistically, found...
The latest incidence and disability-adjusted life-years (DALYs) of major bacterial skin diseases (BSD) their relationship with socioeconomic are not readily available.Describe the global age-standardized DALYs rates BSD analyze socioeconomic.All data were obtained from Global Burden Disease (GBD) 2019 database. correlation between development status was analyzed.The rate are: 169.72 million [165.28-175.44] 0.41 [0.33-0.48]. Of two main BSD, pyoderma cause significantly much heavier burden...
Cyst formation and enlargement in autosomal dominant kidney disease (ADPKD) is mainly driven by aberrantly increased cytosolic cAMP renal tubule epithelial cells. Because the vasopressin V2 receptor (V2R) regulates intracellular levels kidneys, a series of benzodiazepine derivatives were developed targeting V2R. Among these derivatives, compound 25 exhibited potent binding affinity to V2R (Ki = 9.0 ± 1.5 nM) efficacious inhibition (IC50 9.2 3.0 nM). This led suppression cyst growth both an...
As a key dsDNA recognition receptor, cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) plays vital role in innate immune responses. Activated cGAS, by sensing DNA, catalyzes the synthesis of secondary messenger GMP-AMP (cGAMP), which subsequently activates downstream signaling to induce production interferons and inflammatory cytokines. Here, we report Zyg-11 family member B (ZYG11B) as potent amplifier cGAS-mediated Knockdown ZYG11B impairs cGAMP subsequent transcription interferon...
Unconjugated bilirubin (UCB) is generally considered toxic but has gained recent prominence for its anti-inflammatory properties. However, the effects of it on interaction between intestinal flora and organisms how influences immune responses remain unresolved.To investigate role UCB in barrier function inflammation mice with dextran-sulfate-sodium-induced colitis.Acute colitis was induced by 3% (w/v) dextran sulfate sodium salt drinking water 6 d followed untreated 2 d. Concurrently, were...
Abstract Microdamage and its related inflammation contribute to the development of radiographic axial spondyloarthritis (r-axSpA). Inflammation cell death in damaged tissues are associated with cell-free DNA (cfDNA) release. Here we investigated whether circulating cfDNA could be a potential biomarker for evaluating disease activity treatment response r-axSpA. Circulating was detected discovery validation cohort 79 60 newly diagnosed r-axSpA patients respectively 42 healthy controls using...
Abstract 9,9‐bis (diphenylphosphorylphenyl) fluorene (FDPO) and dibenzotetrathienoacene (DBTTA), are synthesized as the neutral anionic ligands, respectively, to prepare Er III coordination polymer [Er(DBTTA) 3 (FDPO)] n . Based on intramolecular energy transfer, optical gains at 1.5 µm demonstrated in ‐doped waveguides under excitations of low‐power light‐emitting diodes (LEDs) instead laser pumping. A ligand‐sensitization scheme between organic ligands 3+ ions an excitation ultraviolet...
Increasingly studies revealed that dysbiosis of gut microbiota plays a pivotal role in the pathogenesis ulcerative colitis (UC). Fecal transplantation (FMT) has drawn more and attention become an important therapeutic approach. This study aims to examine facts about effective components look into potential mechanisms FMT. Colitis was induced by 3% (w/v) dextran sulfate sodium (DSS) drinking water for 7 days. mice were administered oral gavage with fecal suspension, supernatant, bacteria or...
Neurodegenerative diseases including AD is currently one of intractable problems globally due to the insufficiency intervention strategies. Long-term infection Toxoplasma gondii (T. gondii) can induce cognitive impairment in hosts, which closely implicated pathogenesis neurodegenerative diseases. Aconitate decarboxylase 1 (Acod1) and its produced metabolite itaconate (termed Acod1/itaconate axis), have recently attracted extensive interests anti-inflammatory role macrophages. However,...
Chelate phosphine oxide ligand (9,9-dimethyl-9H-xanthene-4,5-diyl) bis (diphenylphosphineoxide) (XPO) is prepared as a neutral to synthesize complex Nd (TTA)3 (TTA = 2-thenoyltrifluoroacetone). An appropriate energy gap between the XPO and TTA ligands, which can support two additional transfer routines from first excited triplet state (T1 ) level of that TTA, improves in complex. Based on intramolecular mechanism, optical gains at 1.06 1.31 µm are demonstrated (XPO)-doped polymer waveguides...
The aim was to compare the efficacy of long-acting and short-acting gonadotropin-releasing hormone (GnRH) agonists by long protocol on embryo quality, endometrial thickness pregnancy rate in vitro fertilization.In this retrospective study, long-term pituitary downregulation, achieved with long- GnRH (GnRHa), performed for patients undergoing fertilization (n = 175).There were no significant differences between group (63.16% vs. 66.26%, p > 0.05), secondary primary infertility (63.47% 66.86%,...
Background The neurotrophic parasite Toxoplasma gondii ( T . ) has been implicated as a risk factor for neurodegenerative diseases. However, there is only limited information concerning its underlying mechanism and therapeutic strategy. Here, we investigated the effects of chronic infection on goal-directed cognitive behavior in mice. Moreover, evaluated preventive effect dimethyl itaconate deficits induced by parasite. Methods model was established orally infecting cysts Dimethyl...
The present study investigated the insulin sensitivity, hypoglycemic, and hypolipidemic activities of ethanolic extract Mirabilis jalapa L. root (EEM) in normal diabetic mice. After induction diabetes with streptozotocin, both mice were singly or repeatedly for 28 days administrated EEM at doses 2, 4, 8 g/kg, respectively. Before diabetes, g/kg 14 injected streptozotocin continued on administration another days. Both after before repeated continually lowered blood glucose level, decreased...