A5065530211- Immune Response and Inflammation
- interferon and immune responses
- Immune cells in cancer
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Advanced Glycation End Products research
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Heat shock proteins research
- Curcumin's Biomedical Applications
- Genetic factors in colorectal cancer
- Amoebic Infections and Treatments
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Atherosclerosis and Cardiovascular Diseases
- Plant Toxicity and Pharmacological Properties
- Antibiotics Pharmacokinetics and Efficacy
- Protein Degradation and Inhibitors
- Acute Myeloid Leukemia Research
Hangzhou Normal University
2014-2024
China Agricultural University
2024
Nanjing University of Chinese Medicine
2017-2022
Hebei North University
2020-2022
Abstract A polarized macrophage response is presumed to have a pivotal role in variety of immunological pathophysiology. However, the molecular mechanism underlying functional shaping remains largely unknown. In this study, we reveal miR-127 development and thereby pathogenesis inflammation lung injury. particular, was demonstrated be prominently induced upon TLR engagement repressed by M2-prone cytokines. Enforced expression macrophages resulted significantly increased production...
Macrophage polarization is critical for dictating host defense against pathogens and injurious agents. Dysregulation of macrophage differentiation has been implicated in infectious inflammatory diseases. Here, we show that protein kinase B/Akt1 signaling induced by Staphylococcus aureus essential shifting macrophages from an antimicrobial phenotype (M1) to a functionally inert signature. Akt1−/−mice consistently had enhanced bacterial clearance greater survival, compared with their wild-type...
Immune and inflammation dysregulation have been associated with the aging process contribute to age-related disorders, but underlying mechanism remains elusive. Here, we employed late-generation Terc knockout (Terc-/-) mice investigate impact of telomere dysfunction on host defense function innate immune cells. Terc-/- displayed exaggerated lung increased mortality upon respiratory staphylococcal infection, although their pathogen-clearing capacity was uncompromised. Mechanistically, found...
Disproportionately high incidence and mortality of respiratory infection such as influenza A virus (IAV) SARS-CoV-2 have been evidenced in the elderly, but role mechanism age-associated immune deregulation disease exacerbation are not well defined. Using a late generation mice deficient telomerase RNA (Terc-/- ), we herein demonstrated that aged were exquisitely susceptible to viral infection, with excessive inflammation increased mortality. Furthermore, identified cGAS/STING pathway, which...
Uncontrolled inflammatory responses cause tissue injury and severe immunopathology. Pharmacological interference of intracellular pro-inflammatory signaling may confer a therapeutic benefit under these conditions. Daphnetin, natural coumarin derivative, has been used to treat diseases including bronchitis. However, the protective effect daphnetin in airway disorders yet be determined, molecular basis for its anti-inflammatory properties is unknown. This paper shows that treatment conferred...
Curcumin has remarkable anti-inflammatory and antioxidant properties. However, its effects on bacterium-induced acute lung injury (ALI) are not fully understood. To investigate the protective of curcumin a mouse model S. aureus-induced ALI. Mice were pretreated with intraperitoneal injection or vehicle 2 h before Staphylococcus aureus instillation. The survival rate bacterial burden after infection recorded. sacrificed for analyses severity pneumonia, integrity barrier, disorder coagulation...
Background: Cervical cancer (CC) is one of the most common cancers among women in world. Long noncoding RNAs and microRNAs were identified as important regulators many physiological processes. The objective this study was to illuminate mechanism X-inactive-specific transcript (XIST)/miR-889-3p/Sine oculis homeobox 1 (SIX1) axis CC. Methods: expression levels XIST, miR-889-3p, SIX1 detected by quantitative real-time polymerase chain reaction. Cell proliferation assessed cell counting Kit 8...
5-Hydroxymethylfurfural (5-HMF) is a common reaction product during heat processing and the preparation of many types foods Traditional Chinese Medicine formulations. The aim this study was to evaluate protective effect 5-HMF on endotoxin-induced acute lung injury (ALI) underlying mechanisms. Our findings indicate that attenuated lipopolysaccharide (LPS)-induced ALI in mice by mitigating alveolar destruction, neutrophil infiltration release inflammatory cytokines. Furthermore, activation...
This study aimed to the characterization and potential lipid-lowering effects of new isolated lactic acid bacteria from feces healthy adult cats.
Chlamydia pneumonia (C. pneumonia) remains one of the leading causes bacterial and has been implicated in pathogenesis some inflammation-related diseases, such as asthma, chronic obstructive pulmonary disease, vascular diseases. Heat shock protein 60 is pathogenic components C. that closely associated with inflammatory disorders. However, molecular basis for immunopathologic property chlamydial heat (cHSP60) not elucidated. In this article, we report MAPK kinase 3 (MKK3) essential...
Endometrial cancer (EC) is a multi‑factorial disease of which pathogenesis has not been fully elucidated. The function and underlying mechanism microRNA‑20a‑5p (miR‑20a‑5p) in EC remain poorly understood. present study aimed to analyze the association between miR‑20a‑5p expression clinicopathological characteristics patients with EC. Whether could inhibit progression by targeting janus kinase 1 (Jak1) was subsequently investigated. To do so, human tissues paracancerous were collected from 47...
To explore the potential function of methyltransferase-like 5 (METTL5) in uterine corpus endometrial carcinoma (UCEC) and verify relationship between deficient DNA mismatch repair (MMR) METTL5. We used bioinformatics to predict possible role METTL5 molecular biology methods analyze expression. observed UCEC proliferation, development, apoptosis using a knockdown lentivirus and, coupled with Western blot analysis, detected microsatellite instability (MSI) MMR. Gene ontology (GO) Kyoto...
5-Hydroxymethylfurfural (5-HMF) exists in a wide range of sugar-rich foods and traditional Chinese medicines. The role 5-HMF antiviral innate immunity its mechanism have not been reported previously. In this study, we reveal for the first time that upregulates production retinoic acid-inducible gene I (RIG-I)-mediated type interferon (IFN) as response to viral infection. IFN-β IFN-stimulated chemokine expressions induced by vesicular stomatitis virus (VSV) are upregulated RAW264.7 cells...
The increasing rising of multiple drug-resistant Staphylococcus aureus has become a major public health concern, underscoring pressing need for developing therapies essentially based on the understanding host defensive mechanism. In present study, we showed that microRNA (miR)-127 played key role in controlling bacterial infection and conferred profound protection against staphylococcal pneumonia. protective effect miR-127 was largely dependent its regulation macrophage bactericidal activity...
Abstract Acute promyelocytic leukemia (APL) therapy involves the compounds cytotoxic to both malignant tumor and normal cells. Relapsed APL is resistant subsequent chemotherapy. Novel agents are in need kill cells selectively with minimal toxicity. DDX5 has been recognized be a novel target suppress acute myeloid (AML). However, role of remains elusive APL. Here DDX5-targeting fully human monoclonal autoantibody named after 2F5 was prepared. It demonstrated that inhibited cell proliferation...
The emergence of nosocomial infections caused by hypervirulent and carbapenem-resistant
Polyadenosine diphosphate-ribose polymerase 7 (PARP7) acts as a suppressor of the type I interferon (IFN) signaling pathway via suppressing TANK-binding protein 1 (TBK1). Research study indicates that inhibition PARP7 could potentially regulate tumor immunity. However, effect on innate antiviral immunity in macrophages well underlying mechanism have not been demonstrated else well. We report herein inhibitor clinical candidate RBN-2397 augment (IFN-I) production by elevating retinoic...
Rapid activation of macrophages plays a central role in eliminating invading bacteria as well triggering the inflammatory responses, but how anti-bacterial and responses are coordinated, terms macrophages, is not completely understood. In this study, we demonstrated that Staphylococcus aureus (S. aureus) induced expression CD200 murine dose-dependent manner. We found significantly suppressed S. aureus-induced production nitric oxide proinflammatory cytokines mouse macrophages. Concurrently,...
Abstract The coordination of restraining and priming antiviral signaling constitute a fundamental aspect immunological functions. However, we currently know little about the molecular events that can translate pathogenic cues into appropriate code for defense. Our present study reports specific role B cell lymphoma (Bcl)6 as checkpoint in initiation host response to cytosolic RNA viruses. Remarkably, Bcl6 specifically binds interferon-regulatory factor (IRF)7 loci restrains its...