A5061821520- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- RNA modifications and cancer
To explore the potential function of methyltransferase-like 5 (METTL5) in uterine corpus endometrial carcinoma (UCEC) and verify relationship between deficient DNA mismatch repair (MMR) METTL5. We used bioinformatics to predict possible role METTL5 molecular biology methods analyze expression. observed UCEC proliferation, development, apoptosis using a knockdown lentivirus and, coupled with Western blot analysis, detected microsatellite instability (MSI) MMR. Gene ontology (GO) Kyoto...
To determine the role of RNA-binding protein with serine-rich domain 1 (RNPS1) in uterine corpus endometrial carcinoma (UCEC), RNPS1 knockdown UCEC development vitro and vivo, relationship between mismatch repair (MMR) UCEC.We predicted potential function using bioinformatics systems. The expression tissues cell lines was analyzed by western blotting immunohistochemistry. MMR assessed blotting. proliferation apoptosis cells were under conditions, regulation detected suppressing Notch...