A5100379132- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Air Quality Monitoring and Forecasting
- Sulfur Compounds in Biology
- Signaling Pathways in Disease
- Supramolecular Self-Assembly in Materials
- Axon Guidance and Neuronal Signaling
- Genetic and phenotypic traits in livestock
- Circular RNAs in diseases
- Climate Change and Health Impacts
- Calcium signaling and nucleotide metabolism
- S100 Proteins and Annexins
- Neurological Disease Mechanisms and Treatments
- Digestive system and related health
- Neuroscience and Neuropharmacology Research
- Bioactive Compounds and Antitumor Agents
- Supramolecular Chemistry and Complexes
- Wnt/β-catenin signaling in development and cancer
Nanjing University of Chinese Medicine
2025
Nanjing Drum Tower Hospital
2025
China Medical University
2019-2024
Northwest Women's and Children's Hospital
2024
Peking University
2018-2024
Integrated Chinese Medicine (China)
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Chinese Institute for Brain Research
2021-2024
Children's Hospital of Fudan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Abstract A polarized macrophage response is presumed to have a pivotal role in variety of immunological pathophysiology. However, the molecular mechanism underlying functional shaping remains largely unknown. In this study, we reveal miR-127 development and thereby pathogenesis inflammation lung injury. particular, was demonstrated be prominently induced upon TLR engagement repressed by M2-prone cytokines. Enforced expression macrophages resulted significantly increased production...
Abstract Background Xylitol, a white or transparent polyol sugar alcohol, is digestible by colonic microorganisms and promotes the proliferation of beneficial bacteria production short-chain fatty acids (SCFAs), but mechanism underlying these effects remains unknown. We studied mice fed with 0%, 2% (2.17 g/kg/day), 5% (5.42 g/kg/day) (weight/weight) xylitol in their chow for 3 months. In addition to vivo digestion experiments mice, 3% (weight/volume) (0.27 g/kg/day human being) was added...
Traumatic injuries can trigger inflammatory reactions, leading to profound neuropathological consequences. However, the immune capacity of neurons, distinct from that cells or glial cells, in response traumatic insults remains be fully characterized. In this study, we demonstrate neurons detect, cell autonomously, distant axonal damage, resulting rapid production a specific collection cytokines and chemokines. This neuronal appears spatially temporally separated injury-induced axon...
Uncontrolled inflammatory responses cause tissue injury and severe immunopathology. Pharmacological interference of intracellular pro-inflammatory signaling may confer a therapeutic benefit under these conditions. Daphnetin, natural coumarin derivative, has been used to treat diseases including bronchitis. However, the protective effect daphnetin in airway disorders yet be determined, molecular basis for its anti-inflammatory properties is unknown. This paper shows that treatment conferred...
The nervous system can modulate the body's immunity. However, how efferent neural signals reach out to control local immunity remains incompletely understood. Here, we report ImmuView procedure for whole-tissue 3D assessment of innervations in intact immune organs adult mice. This advanced imaging technique revealed an intricate, panicle-shaped sympathetic architecture parenchyma spleen but not other organs, including lymph nodes, Peyer's patch, and thymus. In contrast, observed minimal...
Patients with inflammatory bowel disease (IBD) are usually advised to supplement various types of vitamin B12, because B12 is generally absorbed in the colon. Thus, current study, influence cyanocobalamin (CNCBL) or methylcobalamin (MECBL) ingestion on IBD symptoms will be investigated. Then, whether and how application cobalamins would modify taxonomic functional composition gut microbiome mice examined carefully. Dextran-sulfate-sodium-induced were treated MECBL CNCBL; activity index (DAI)...
Arsenic is a toxic environmental contaminant. Long-term exposure to arsenic through drinking water induces human cancers. However, it as yet uncertain about the mechanisms of induced carcinogenesis. Although effects low-dose arsenicals on proliferation and cell cycle have been revealed by short time exposure, evidences for long-term were seldom reported. The detailed mechanism has unclear supplemented constantly. In present study, we used normal keratinocytes (HaCat) study long-term, sodium...
Microglia activation is a crucial event in neurodegenerative disease. The depression of microglial inflammatory response considered promising therapeutic strategy. NFκB signaling, including IKK/IκB phosphotylation, p65 nucelus relocalization and NFκB-related genes transcription are prevalent accepted to play important role activation. (+)-JQ1, BRD4 inhibitor firstly discovered as an anti-tumor agent, was later confirmed be anti-inflammatory compound. However, its effect microglia central...
The management of poor responders is a significant challenge for both patients and clinicians. aim this study was to evaluate the effectiveness intra-ovarian injection Platelet-Rich Plasma (PRP) combined with successive accumulated embryo transfer in improving outcomes Poor Ovarian Response(POR) based on POSEIDON criteria. This single-center, retrospective before-after conducted at private reproductive center, involving 49 women diagnosed POR, indicated by an AMH level less than 1.2 ng/ml....
Background: Previous studies have shown that cellular senescence is strongly associated with tumorigenesis and the tumor microenvironment.Accordingly, we developed a novel prognostic signature for intrahepatic cholangiocarcinoma (ICCA) based on senescence-associated long non-coding RNAs (SR-lncRNAs) identified lncRNA-miRNA-mRNA axis involving in ICCA.Methods: Based 197 genes (SRGs) from Genacards their expression Fu-ICCA cohort, 20 lncRNAs as through co-expression cox-regression...
Previous studies supported a role of hypothalamic inflammation in fine ambient particulate matter (PM2.5) exposure-mediated diabetes development. We therefore investigated the effects PM2.5 exposure on insulin resistance and disorders hepatic glucose lipid metabolism via inflammation. KKAy mice, genetically susceptible model type II mellitus, were administered intra-cerebroventricularly with IKK2 inhibitor (IMD-0354) exposed to either concentrated or filtered air (FA) for 4 weeks...