A5061860314- Adipose Tissue and Metabolism
- Immune cells in cancer
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- interferon and immune responses
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Diabetes Management and Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Pain Mechanisms and Treatments
- Enzyme Structure and Function
- IL-33, ST2, and ILC Pathways
- Signaling Pathways in Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Neurogenesis and neuroplasticity mechanisms
- Vagus Nerve Stimulation Research
Tsinghua University
2003-2024
Chinese Academy of Sciences
2024
Institute of Subtropical Agriculture
2024
University of Chinese Academy of Sciences
2024
Center for Life Sciences
2017-2024
King Center
2023-2024
Peking University
2023-2024
Shanxi Medical University
2024
Cornell University
2024
Weill Cornell Medicine
2024
Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, dendritic cell differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU.1 or Spi-B. How these IRFs target genes in most T cells is enigmatic given the absence of specific Ets partners. Chromatin immunoprecipitation sequencing helper 17 (T(H)17) reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)-IRF (AICEs) co-bound BATF, an AP-1 required T(H)17, BATF bind...
Neuroinflammation is a crucial mechanism in many neurological disorders. Injury to the peripheral sensory nerves leads neuroinflammatory response somatosensory pathway, from dorsal root ganglia (DRG) spinal cord, contributing neuropathic pain. How immune reaction initiated peripherally and propagated cord remains less clear. Here, we find that ciliary neurotrophic factor (CNTF), highly expressed Schwann cells, mediates through activating signal transducer activator of transcription 3 (STAT3)...
Abstract NKCC and KCC transporters mediate coupled transport of Na + +K +Cl − K across the plasma membrane, thus regulating cell Cl concentration volume playing critical roles in transepithelial salt water neuronal excitability. The function these has been intensively studied, but a mechanistic understanding awaited structural studies transporters. Here, we present cryo-electron microscopy (cryo-EM) structures two cation-chloride cotransporters human NKCC1 (SLC12A2) mouse KCC2 (SLC12A5),...
Cancer-associated cachexia (CAC) is a hypermetabolic syndrome characterized by unintended weight loss due to the atrophy of adipose tissue and skeletal muscle. A phenotypic switch from white beige adipocytes, phenomenon called browning, accelerates CAC increasing dissipation energy as heat. Addressing mechanisms (WAT) browning in CAC, we now show that cachexigenic tumors activate type 2 immunity cachectic WAT, generating neuroprotective environment increases peripheral sympathetic activity....
Significance Neuronal innervation in the adipose tissues plays a crucial role regulating thermogenic capacity and metabolic homeostasis. The tissue-wide nerves display large extent of structural plasticity under physiological pathological conditions that alter neuronal control states. We find here is regulated by immune cells, which constitutes an appealing way to reshape neural-controlled energy balance targeting components.
Traumatic injuries can trigger inflammatory reactions, leading to profound neuropathological consequences. However, the immune capacity of neurons, distinct from that cells or glial cells, in response traumatic insults remains be fully characterized. In this study, we demonstrate neurons detect, cell autonomously, distant axonal damage, resulting rapid production a specific collection cytokines and chemokines. This neuronal appears spatially temporally separated injury-induced axon...
Sympathetic arborizations act as the essential efferent signals in regulating metabolism of peripheral organs including white adipose tissues (WAT). However, whether these local neural structures would be plastic nature, and how such plasticity might participate specific metabolic events WAT, remains largely uncharacterized. In this study, we exploit new volume fluorescence-imaging technique to observe significant, also reversible, intra-adipose sympathetic mouse inguinal WAT response cold...
The vascular system is central to sustaining tissue survival and homeostasis. Blood vessels are densely present in adipose tissues exert essential roles their metabolism. However, conventional immunohistochemistry methods have intrinsic limitations examining the 3D network as well other organs general. We established a volume fluorescence-imaging technique visualize vasculatures mouse by combining optimized steps of whole-mount immunolabeling, optical clearing, lightsheet...
Toll-like receptors (TLRs) are a class of proteins that play critical roles in recognizing pathogens and initiating innate immune responses. TASL, recently identified adaptor protein for endolysosomal TLR7/8/9 signaling, is recruited by the lysosomal proton-coupled amino-acid transporter SLC15A4, then activates IRF5, which turn triggers transcription type I interferons cytokines. Here, we report three cryo-electron microscopy (cryo-EM) structures human SLC15A4 apo monomeric dimeric state as...
TRPML1 channel is a non-selective group-2 transient receptor potential (TRP) with Ca2+ permeability. Located mainly in late endosome and lysosome of all mammalian cell types, indispensable the processes endocytosis, membrane trafficking, biogenesis. Mutations cause severe lysosomal storage disorder called mucolipidosis type IV (MLIV). In present study, we determined cryo-electron microscopy (cryo-EM) structures Mus musculus (mTRPML1) lipid nanodiscs Amphipols. Two distinct states mTRPML1...
Alveolar macrophages (AMs) are critical mediators of pulmonary inflammation. Given the unique lung tissue environment, whether there exist AM-specific mechanisms that control inflammation is not known. Here, we found among various tissue-resident macrophage populations, AMs specifically expressed Lepr , encoding receptor for a key metabolic hormone leptin. AM-intrinsic signaling attenuated in vivo, manifested as subdued acute injury yet compromised host defense against Streptococcus...
Atopic dermatitis (AD) is a prevalent inflammatory skin disorder in which patients experience recurrent eczematous lesions and intense itching. The colonization of Staphylococcus aureus (S. aureus) correlated with the severity disease, but its role AD development remains elusive. Using single-cell RNA sequencing, we uncovered that keratinocytes activate distinct immune response characterized by induction Il24 when exposed to methicillin-resistant S. (MRSA). Further experiments using animal...