A5019267897- Physics of Superconductivity and Magnetism
- Receptor Mechanisms and Signaling
- Advanced Condensed Matter Physics
- Superconducting Materials and Applications
- Alzheimer's disease research and treatments
- Genetic and Kidney Cyst Diseases
- Antifungal resistance and susceptibility
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Superconductivity in MgB2 and Alloys
- Autophagy in Disease and Therapy
- Quantum Chromodynamics and Particle Interactions
- Ion channel regulation and function
- Fungal and yeast genetics research
- Quantum and electron transport phenomena
- Analytical Chemistry and Chromatography
- Hedgehog Signaling Pathway Studies
- Magnetic and transport properties of perovskites and related materials
- Neuroscience and Neuropharmacology Research
- Iron-based superconductors research
- Cellular transport and secretion
- Microtubule and mitosis dynamics
- Neurotransmitter Receptor Influence on Behavior
- Renal and related cancers
- Glycosylation and Glycoproteins Research
Maharishi Markandeshwar University, Mullana
2025
Yale University
2017-2024
University of Kalyani
2015-2022
Saha Institute of Nuclear Physics
2012-2019
Queen Mary University of London
2014
Abstract NKCC and KCC transporters mediate coupled transport of Na + +K +Cl − K across the plasma membrane, thus regulating cell Cl concentration volume playing critical roles in transepithelial salt water neuronal excitability. The function these has been intensively studied, but a mechanistic understanding awaited structural studies transporters. Here, we present cryo-electron microscopy (cryo-EM) structures two cation-chloride cotransporters human NKCC1 (SLC12A2) mouse KCC2 (SLC12A5),...
Abstract Cation-chloride cotransporters (CCCs) NKCC1 and NKCC2 catalyze electroneutral symport of 1 Na + , K 2 Cl − across cell membranes. mediates trans-epithelial secretion regulates excitability some neurons is critical to renal salt reabsorption. Both transporters are inhibited by the so-called loop diuretics including bumetanide, these drugs a mainstay for treating edema hypertension. Here, our single-particle electron cryo-microscopy structures supported functional studies reveal an...
The existence of a cilia-dependent cyst activation (CDCA) pathway underlying autosomal dominant polycystic kidney disease was identified by showing that progression following loss polycystins is significantly suppressed removal structurally intact cilia. We applied translating ribosome affinity purification RNASeq on pre-cystic mouse kidneys to determine cell-autonomous in vivo translatome associated with CDCA and Glis2 as an early effector polycystin signaling. Here, discover additional...
Alzheimer's Disease (AD) manifests neuronal loss. On the premises of Grb2 overexpression in AD mouse brain and tissues patients, our study primarily focuses on stability cytoskeletal proteins context degenerative like conditions. Two predominant molecular features AD, extracellular accumulation Aβ oligomers intracellular elevation AICD levels, have been used to closely inspect series signaling events. In their presence, multiple pathways involving ROCK PAK1 lead disassembly cytoskeleton...
The ascertainment of elevated levels amyloid-β protein precursor intracellular domain (AICD) in Alzheimer's disease (AD) brains and the fact that it contributes to AD-like pathology has geared search toward a new paradigm. While studying endogenous as well overexpressed Grb2-AICD interact ion AD cell models, was found Grb2 co-localized compartments along with AICD. We report now these vesicles form clathrin dynamin independent manner. Both types mature into autophagosomes, merge lysosomes,...
SUMMARY The serotonin transporter (SERT) removes synaptic and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, inward-open. All known inhibitors outward-open state except ibogaine, which has an unusual profile stabilizes inward-open conformation. Unfortunately, ibogaine promiscuous cardiotoxic, limiting understanding ligands. We computationally docked over 200 million small molecules against stabilized SERT. Thirty-six top-ranking compounds...
Based on the observations that Grb2 overexpression altered trafficking route of amyloid-β protein precursor (AβPP) by inhibiting its release via exosomal vesicles, and subsequently increased endogenous level, in present study we aimed to elucidate mechanism traffic impairment role different domains this process. We found N-SH3 domain was involved vesicular localization. The C-SH3 could also form very small puncta, but were not characteristic containing vesicles. Vesicles N-SH3-SH2 had a...
Growth factor receptor-bound protein 2 (Grb2) is an adaptor which participates in trafficking pathways alongside its role signaling. Proteins important for actin remodeling and cellular compartmentalization contain SRC Homology 3 (SH3) binding motifs that interact with Grb2. While studying the Grb2-amyloid precursor (APP) intracellular domain (AICD) interaction Alzheimer's disease cell line models, it was seen Grb2 colocalized to compartments mature into autophagosomes. The entrapping of...
Amyloid-β protein precursor intracellular domain (AICD), which exerts effects by interacting with proteins involved in a plethora of biological processes, is key player behind the pathophysiology Alzheimer's disease (AD). Keeping mind that overwhelming presence AICD would m imic AD-like conditions neuroblastoma cell lines, we hypothesized alteration proteomic expression pattern these cells compared to their normal proteome. The rationale study was distinguish between symptomatic...
N-acetylglucosamine (GlcNAc), an important amino sugar at the infection sites of fungal pathogen Candida albicans, triggers multiple cellular processes. GlcNAc import cell surface is mediated by transporter, Ngt1 which seems to play a critical role during signaling. We have investigated dynamics that provide platform for further studies aimed understanding mechanistic insights regulating process(es) in C. albicans. The expression this transporter prolific and highly sensitive even very low...
The change in current through an organic light emitting diode (OLED) when it is placed a magnetic field has been dubbed magnetoresistance and provides means to understand the spin interactions that are occurring working devices. Whilst there wide range of have proposed be cause measured effects, still need identify their individual roles particular how they respond applied field. In this work, we investigate effect changing balance electron hole injection simple aluminium...
We present numerical results of the recently derived polaronic t-Jp model, which accounts for realistic long range Coulomb repulsion and strong Fröhlich electron-phonon interactions high temperature superconductivity in doped polar insulators. Different cluster geometries 18-sites with two particles are studied. It appears that ground state energy decreases hopping polarons indicating an increase tendency to couple each other. The entropy curves show system goes more ordered polaron all geometries.
The possibilities of the formation superlight small bipolaron in doped polar insulators have been discussed within t-Jp model derived from Fröhlich and realistic long range Coulomb interaction. Increase t/Jp dresses electrons forming polarons bipolarons. Formation inter-site (S1) bipolarons is favored by ratio. Entropy curves indicate that this lead to a more ordered state system.
) interactions on the charge gap, spin gap and effective exchange interaction has been investigated. Charge shows a gapped behavior. Spin curves establish gapless behavior at small
We present numerical results of the t-J-V model in an 8-site tilted square cluster using exact diagonalization (ED) method with periodic boundary conditions. Effective hopping amplitude initially increases inter-site Coulomb repulsion (V), but decreases at larger V's. The hole-hole correlation distances smaller V. With increase repulsion, system becomes ordered. specific heat curves confirm non-Fermi liquid behavior under model.