A5089660372- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Renal Diseases and Glomerulopathies
- Biomedical Research and Pathophysiology
- Amino Acid Enzymes and Metabolism
- Microtubule and mitosis dynamics
- Vascular Malformations and Hemangiomas
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- DNA Repair Mechanisms
- Renal cell carcinoma treatment
- Micro and Nano Robotics
- Mitochondrial Function and Pathology
- Hedgehog Signaling Pathway Studies
- Tissue Engineering and Regenerative Medicine
- Pediatric Urology and Nephrology Studies
- Endoplasmic Reticulum Stress and Disease
- Protist diversity and phylogeny
Instituto de Investigación Sanitaria de Santiago
2017-2025
Fundación Pública Galega de Medicina Xenómica
2021-2025
Yale University
2022-2024
Instituto de Salud Carlos III
2020-2021
The Polycystic Kidney Disease (PKD) is characterized by progressive renal cyst development and other extrarenal manifestation including Liver (PLD). Phenotypical characterization of animal models mimicking human diseases are commonly used, in order to, study new molecular mechanisms identify therapeutic approaches. main biomarker disease progression total volume kidney liver both mouse, which correlates with organ function. For this reason, the estimation number area tissue occupied cysts,...
(1) Background: Polycystic liver disease (PLD) is a heterogeneous group of congenital disorders characterized by bile duct dilatation and cyst development derived from cholangiocytes. Nevertheless, the cystogenesis mechanism currently unknown PLD treatment limited to transplantation. Novel efficient therapeutic approaches are th6us needed. In this context, present work has principal aim find novel molecular pathways, as well new targets, involved in hepatic process. (2) Methods: Quantitative...
Abstract Background and Aims Activation of the NOTCH signalling pathway has been described in several progressive kidney diseases. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disease caused by PKD1 or PKD2 mutations, which codify for Polycystin-1 Polycystin-2 proteins, respectively. ADPKD prevalence among 1:800 1:1000 live births characterized fluid-filled renal cysts. During this process production chemokines, cytokines growth factors epithelial cells, interstitial...