A5082043989- Renal Diseases and Glomerulopathies
- Protein Degradation and Inhibitors
- Complement system in diseases
- Psoriasis: Treatment and Pathogenesis
- Chronic Kidney Disease and Diabetes
- interferon and immune responses
- Dialysis and Renal Disease Management
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- Vitamin C and Antioxidants Research
- Pancreatitis Pathology and Treatment
- Asthma and respiratory diseases
- Vitamin D Research Studies
- Multiple Myeloma Research and Treatments
- Acute Kidney Injury Research
- Connective Tissue Growth Factor Research
- Immune Cell Function and Interaction
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Therapeutic Uses of Natural Elements
- Histone Deacetylase Inhibitors Research
- Ion Channels and Receptors
Hospital Universitario Fundación Jiménez Díaz
2020-2024
Universidad Autónoma de Madrid
2022-2024
Instituto de Salud Carlos III
2020-2024
RELX Group (United States)
2023
Spanish Clinical Research Network
2021-2022
Austral University of Chile
2015-2020
Fraunhofer Chile Research Foundation
2016
Chronic kidney disease (CKD) can be considered as a clinical model for premature aging. However, non-invasive biomarkers to detect early damage and the onset of senescent phenotype are lacking. Most preclinical senescence studies in aging have been done very old mice. Furthermore, precise characterization over-time development age-related remain unclear. To address these limitations, activation cellular senescence-associated mechanisms their correlation with structural changes were...
Acute kidney injury (AKI) is more frequent in elderly patients. Mechanisms contributing to AKI (tubular cell death, inflammatory infiltration, impaired mitochondrial function, and prolonged cell-cycle arrest) have been linked cellular senescence, a process implicated regeneration failure progression fibrosis. However, the molecular pathological basis of age-related increase incidence not completely understood. To explore these mechanisms, experimental was induced by folic acid (FA)...
Infectious peritonitis is a leading cause of peritoneal functional impairment and primary factor for therapy discontinuation in dialysis (PD) patients. Although bacterial infections are common episodes, emerging evidence suggests role viral pathogens. Toll-like receptors (TLRs) specifically recognize conserved pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, fungi, thereby orchestrating the ensuing inflammatory/immune responses. Among TLRs, TLR3 recognizes dsRNA...
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treatment may rapidly progress to end-stage renal death. Current immunosuppressive provides limited efficacy an important burden of adverse events. Epigenetic drugs are source novel therapeutic tools. Among them, bromodomain extraterminal domain (BET) inhibitors (iBETs) block the interaction between bromodomains acetylated proteins, including histones transcription factors. iBETs have...
Progressive glomerulonephritis (GN) is characterized by an excessive accumulation of extracellular (ECM) proteins, mainly type IV collagen (COLIV), in the glomerulus leading to glomerulosclerosis. The current therapeutic approach GN suboptimal. Epigenetic drugs could be novel options for human disease. Among these drugs, bromodomain and extra-terminal domain (BET) inhibitors (iBETs) have shown beneficial effects experimental kidney disease fibrotic disorders. Sex-determining region Y-box 9...
Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide. Although remarkable therapeutic advances have been made during last few years, there still exists a high residual risk progression to end-stage renal failure. To further understand pathogenesis tissue injury in this disease, by means Next-Generation Sequencing, we studied microRNA (miRNA) differential expression pattern kidneys Black and Tan Brachyury (BTBR) ob/ob (leptin deficiency mutation) mouse. This...
Cellular communication network-2 (CCN2), also called connective tissue growth factor (CTGF), is considered a fibrotic biomarker and has been suggested as potential therapeutic target for kidney pathologies. CCN2 matricellular protein with four distinct structural modules that can exert dual function factor. Previous experiments using surface plasmon resonance cultured renal cells have demonstrated the C-terminal module of (CCN2(IV)) interacts epidermal receptor (EGFR). Moreover, CCN2(IV)...
Peritoneal dialysis (PD) is a current replacement therapy for end-stage kidney diseases (ESKDs). However, long-term exposure to PD fluids may lead damage of the peritoneal membrane (PM) through mechanisms involving activation inflammatory response and mesothelial-to-mesenchymal transition (MMT), leading filtration failure. depends on complex interaction among external stimuli, intrinsic properties PM, subsequent activities local innate–adaptive immune system. Epigenetic drugs targeting...
Diabetic nephropathy (DN) is currently a leading cause of end-stage renal failure worldwide. Gremlin was identified as gene differentially expressed in mesangial cells exposed to high glucose and experimental diabetic kidneys. We have described that highly biopsies from patients with nephropathy, predominantly areas tubulointerstitial fibrosis. In streptozotocin (STZ)-induced diabetes, deletion using Grem1 heterozygous knockout mice or by silencing, ameliorates damage. To study the vivo role...
Cellular Communication Network Factor 2 (CCN2) is a matricellular protein implicated in cell communication and microenvironmental signaling. Overexpression of CCN2 has been documented various cardiovascular pathologies, wherein it may exert either deleterious or protective effects depending on the pathological context, thereby suggesting that its role system not yet fully elucidated. In this study, we aimed to investigate
Abstract Peritoneal dialysis (PD) is a widely used kidney replacement therapy for end-stage disease (ESKD) patients. However, long-term exposure to PD fluids (PDF) can lead peritoneal membrane (PM) damage, causing ultrafiltration failure and thus discontinuation. Investigating the molecular mechanisms underlying this damage crucial identifying new therapeutic targets mitigate deterioration in Therefore, work we study role of STING inflammation fibrosis. To aim, performed different...
COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overwhelmed Healthcare Systems requiring rapid development of treatments, at least, to reduce severity. Drug repurposing offers a fast track. Here, we discuss potential beneficial effects statins in patients based on evidence that they may target virus receptors, replication, degradation and downstream responses infected cells, addressing both basic research epidemiological information. Briefly,...
<h3>Background</h3> An increase in cough reflex sensitivity to capsaicin COPD has been described some studies, suggesting a role for TRPV1 the disease phenotype. We utilised guinea-pig cigarette-smoke (CS) exposure model investigate an enhanced phenotype, and evaluate of using novel clinical-ready inhibitor, XEN-D0501.<sup>1</sup> Furthermore, we confirmed responses patients dose-response challenge determine E<sub>Max</sub>. <h3>Methods</h3> Guinea-pigs were exposed air/cigarette smoke 1 h,...
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treat-ment may rapidly progress to end-stage renal death. Current immunosuppressive treatment provided limited efficacy an important burden of adverse events. Epigenetic drugs are source novel therapeutic tools. Among them, bromodomain extraterminal domain (BET) inhibitors (iBETs) block the interaction between bromodomains acetylated proteins, including histones transcription factors. iBETs have...