A5011494730- Kidney Stones and Urolithiasis Treatments
- Visual perception and processing mechanisms
- Color perception and design
- Endoplasmic Reticulum Stress and Disease
- Neural dynamics and brain function
- Genetic and Kidney Cyst Diseases
- Porphyrin Metabolism and Disorders
- Biomedical Research and Pathophysiology
- Ophthalmology and Visual Impairment Studies
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Connexins and lens biology
- Ophthalmology and Eye Disorders
- Renal and related cancers
- Heme Oxygenase-1 and Carbon Monoxide
- Multisensory perception and integration
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Glaucoma and retinal disorders
- Metabolism, Diabetes, and Cancer
- Neuroscience and Neural Engineering
- Biochemical effects in animals
- Phytochemical and Pharmacological Studies
- PARP inhibition in cancer therapy
- Aldose Reductase and Taurine
Post Graduate Institute of Medical Education and Research
2025
Yale University
2022-2025
University of Hyderabad
2017-2023
Panjab University
2016-2022
Durham University
2011-2012
University of Otago
2008-2012
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic disorder, affecting over 10 million individuals worldwide. Cystic expansion typically progresses to failure and also involves liver with limited treatment options. Pathogenic variants in PKD1 or PKD2 account for 85-90% of cases. Genetic re-expression Pkd1 Pkd2 has been shown partially reverse key characteristics phenotype mice. Despite advancements understanding basis, it remains unclear whether...
Chemoprevention using natural agents has emerged as a new and promising strategy for reducing cancer burden. Sesamol, water soluble lignin, is potent antioxidant with potential anticancer activities. Its small size (molecular weight: 138.34g) coupled easy permeability (log P: 1.29) results in its excessive systemic loss therefore, compromising local bioavailability. Furthermore, irritant nature of sesamol limits application on skin per se.Present study aims to evaluate chemopreventive...
Abstract Modern treatment interventions for kidney stones are wrought with side-effects, hence the need alternative therapies such as plant-based medicines. We have previously documented through in vitro studies that statistically optimized aqueous extract of Tribulus terrestris ( Zygophyllaceae family) possesses antiurolithic and antioxidant potential. This provides strong scientific foundation to conduct vivo efficacy preclinical safety corroborate lend further proof its ability prevent...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of chronic and fourth leading end-stage disease, accounting for over 50% prevalent cases requiring renal replacement therapy. There a pressing need improved therapy ADPKD. Recent insights into pathophysiology ADPKD revealed that cyst cells undergo metabolic changes up-regulate aerobic glycolysis in lieu mitochondrial respiration energy production, process ostensibly fuels their increased proliferation....
Abstract Sensory storage shows a short-lived part-report advantage that survives an aftercoming visual noise pattern (Smithson & Mollon, 2006). We tested whether such different types of high-contrast mask. The target was 3 × 4 array digits. mask could be (a) pattern, (b) eights, or (c) random In preliminary experiment, and were interleaved (at 140 Hz) contrast varied to determine the level at which performance fell chance. main separated by inter-stimulus-interval (ISI) 100, 150, 200 ms. An...
To investigate visual performance during reading under different illumination sources.This experimental quantitative study included 40 (20 females and 20 males) emmetropic participants with no history of ocular pathology. The were randomly assigned to read a near task four illuminations (400-lux constant): compact fluorescent light (CFL), tungsten (TUNG), tube (FLUO), emitting diode (LED). Subsequently, we evaluated the participants' experiences eight symptoms comfort.The mean age was 19.86...
Significance Statement XBP1 activation in neonatal and adult doxycycline-inducible murine models of ADPKD due to a hypomorphic polycystin-1 missense mutation orthologous human PC1R2220W delays cyst formation. Activating XBP1s, pro-chaperone inducer the endoplasmic reticulum stress response, can improve steady-state expression, ciliary trafficking, cleavage mutant protein, providing initial vivo proof concept that modulating levels poorly functioning PC1 alleles slow progression kidney...
To investigate the quality of life (QoL) in a sample color vision deficit (CVD) patients India and how deficiency affects them psychologically, economically, productivity related to their work occupation.A descriptive case-control study design using questionnaire was conducted on N = 120 participants, whom 60 were CVD (52 male eight female) who visited two eye facilities Hyderabad between 2020 2021 age-matched normal participants served as controls. We validated English-Telugu adapted...
During binocular rivalry, one stimulus is visible (dominant), while the other invisible (suppressed); after a few seconds, perception reverses. To determine whether these alternations involve competition between eyes or images, we measured suppression depth to monocular probes. We did so in conventional rival stimuli and swapping at 1.5 Hz (both sorts of rivalry were shown either with without 18-Hz flicker). The conditions cause that could images both. eye-swapping images. Probes small spot...
The part-report advantage has been used to identify short-lived forms of visual storage (Sperling, 1960). We adopt the paradigm test whether memory can preserve, for a brief time, successive inputs and their temporal order. In our experiments, two arrays, each 4 digits, were presented on trial. arrays spatially coincident, was followed by random pattern-mask. conditions, an auditory cue indicated participant should report first array or second array. results consistently showed advantage,...
Glutamate excitotoxicity and endoplasmic reticulum (ER) recently have been found to be instrumental in the pathogenesis of various neurodegenerative diseases. However, paucity literature deciphering inter-linkage among glutamate receptors, behavioral alterations, ER demands thorough exploration. Reckoning aforesaid concerns, a prospective study was outlined delineate influence stress inhibition via 4-phenylbutyric acid (PBA) on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic (AMPA)...
During binocular rivalry, perception alternates between two different images presented one to each eye. At any moment, image is visible, dominant, while the other invisible, suppressed. Alternations in during rivalry could involve competition eyes, eye-rivalry, or images, image-rivalry, both. We measured response criteria, sensitivities, and thresholds brief contrast increments of rival stimuli conventional displays a display which swapped eyes every 333 ms–swap rivalry–that necessarily...
Purpose: To investigate the psychological pleasure of reading and visual cognition under two colour luminance.Methods: A comparative study sixty participants with emmetropia no history ocular pathology was conducted at Vision Sciences Laboratory, School Medical Sciences, University Hyderabad, TS,
Apocynin has become a drug of choice in NADPH oxidase induced pathological conditions. Hyperoxaluria is one such condition where involved eliciting renal injury.Recently apocynin shown to reverse the transcriptome profile oxidaseassociated genes and reduced oxidative burden hyperoxaluric animals. The poor solubility this creates certain apprehensions about its bioavailability. PLGA (Poly Lactic co-Glycolic Acid) encapsulation nanoparticles have showed induce sustain release henceforth...
Purpose: To demonstrate any transient short-term effect of a particular type breathing exercise (alternate nostril Nadi Shuddhi pranayama exercise) on the intraocular pressure (IOP) in glaucomatous as well healthy eyes. Methods: A prospective, nonrandomized, observational, cross-sectional study was conducted tertiary eyecare hospital setup recruiting 3 groups subjects—glaucoma group and normal that underwent did not. IOP recorded at baseline, then 4 minutes after 10 cycles also...
Abstract Background and Aims Induced prismatic effects due to poor fitting spectacle frames is a common problem, seen in most of the wearers this improper often optical center demarcation on lenses error causes asthenopic symptoms diplopia. However, these errors are developing countries lack awareness, hence standardized regulation required. The current study aimed estimate amount effect that induced decentration an ophthalmic lens. Methods A quantitative cross‐sectional was conducted single...