A5026458978- Neurotransmitter Receptor Influence on Behavior
- Analytical Chemistry and Chromatography
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Neuroscience and Neuropharmacology Research
- Renal function and acid-base balance
- Insect Utilization and Effects
Yale University
2022-2023
Wesleyan University
2021
SUMMARY The serotonin transporter (SERT) removes synaptic and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, inward-open. All known inhibitors outward-open state except ibogaine, which has an unusual profile stabilizes inward-open conformation. Unfortunately, ibogaine promiscuous cardiotoxic, limiting understanding ligands. We computationally docked over 200 million small molecules against stabilized SERT. Thirty-six top-ranking compounds...
Abstract Drosophila sechellia is a dietary specialist endemic to the Seychelles islands that has evolved consume fruit of Morinda citrifolia. When ripe, M. citrifolia contains octanoic acid and hexanoic acid, two medium-chain fatty volatiles deter are toxic generalist insects. resistance these allowing it feed almost exclusively on this host plant. The genetic basis been focus multiple recent studies, but mechanisms govern in D. remain unknown. To understand how specialize avoid effects we...