A5100325411- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Insect and Arachnid Ecology and Behavior
- Neuroscience and Neural Engineering
- Neuroscience of respiration and sleep
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Diet and metabolism studies
- Pharmacological Receptor Mechanisms and Effects
- RNA modifications and cancer
- S100 Proteins and Annexins
- Biological and pharmacological studies of plants
- Neurological Disorders and Treatments
- Signaling Pathways in Disease
- Computational Drug Discovery Methods
China Academy of Chinese Medical Sciences
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Guang’anmen Hospital
2023-2025
Xidian University
2022-2024
Ningbo University
2024
Chaohu Hospital of Anhui Medical University
2024
Peking University
2024
China Pharmaceutical University
2021-2023
Henan University of Technology
2023
Shanghai Cancer Institute
2023
Traumatic injuries can trigger inflammatory reactions, leading to profound neuropathological consequences. However, the immune capacity of neurons, distinct from that cells or glial cells, in response traumatic insults remains be fully characterized. In this study, we demonstrate neurons detect, cell autonomously, distant axonal damage, resulting rapid production a specific collection cytokines and chemokines. This neuronal appears spatially temporally separated injury-induced axon...
Chaihu Shugan San (CSS) is a common antidepressant prescription in traditional Chinese medicines. However, its active ingredients and mechanisms are unknown. The aim of this study was to explore the potential pharmacological CSS for treatment major depressive disorder (MDD).Active compounds were screened using Traditional Medicine Systems Pharmacology database. Compound-related targets retrieved SwissTargetPrediction MDD-related determined DisGeNET, Therapeutic Target Database DrugBank...
Abstract Background Pain and depression often occur simultaneously, but the mechanism of this condition is still unclear. Methods The aim study was to examine alterations monoamine neurotransmitters, hypothalamic–pituitary–adrenal (HPA) axis hormones, inflammation cytokines in hyperalgesia comorbidities. reserpine-induced “Sprague Dawley” (SD) rat models were used, concentrations neurotransmitters serotonin (5-HT), norepinephrine (NE), dopamine (DA), their metabolic products...
Indoleamine 2,3-dioxygenase-1 (IDO1) plays an important role in tumor immune escape. However, unsatisfactory clinical efficacies of selective IDO1 inhibitors have impeded their further development, suggesting that they do not exert sufficient antitumor effects by selectively inhibiting IDO1. IDO2, isoenzyme IDO1, is overexpressed some human tumors, and emerging evidence suggests concomitant inhibition IDO1/2 may synergistic cancer treatment, revealing a promising immunotherapeutic strategy....
Abstract Despite burgeoning evidence for cortical hyperarousal in insomnia disorder, the existing results on electroencephalography spectral features are highly heterogeneous. Phase‐amplitude coupling, which refers to modulation of low‐frequency phase a high‐frequency amplitude, is probably more sensitive quantitative measure characterizing abnormal neural oscillations and explaining therapeutic effect repetitive transcranial magnetic stimulation treatment patients with disorder. Sixty...
A breakthrough in the performance of bionic optical structures will only be achieved if we can obtain an in-depth understanding synergy mechanisms operating natural and find ways to imitate them. In this work, inspired by feline eyes, substrate that takes advantage a synergistic effect occurs between resonant reflective was designed. The components leads Raman enhancement factor (EF) 1.16 × 107, which is much greater than using reflective/resonant cavities on their own. Finite-difference...
Research on the imbalance of proopiomelanocortin (POMC)/agouti-related protein (AgRP) neurons in hypothalamus holds potential insights into pathophysiology diabetes. Jinkui Shenqi pills (JSP), a prevalent traditional Chinese medicine, regulate hypothalamic function and treat To investigate hypoglycemic effect JSP explore probable mechanism treating A type 2 diabetes mouse model was used to pharmacodynamics JSP. The glucose-lowering efficacy assessed through various metrics including body...
Chaihu Shugan San (CSS) has a long history for treating major depressive disorder (MDD), which been verified effectively and safely in clinical studies. Deficient angiogenesis plays important roles MDD. However, the underlying mechanisms of CSS on remain poorly understood.Network pharmacology analysis was applied to explore potential angiogenic targets pathways between These would be validated chronic unpredictable mild stress (CUMS)-induced depressive-like mice by Western blots,...
Indoleamine 2,3-dioxygenase 2 (IDO2), a closely related homologue of well-studied immunomodulatory enzyme IDO1, has been identified as pathogenic mediator inflammatory autoimmunity in preclinical models. Therapeutic targeting IDO2 autoimmune diseases challenging due to the lack small-molecule inhibitors. Here, based on our previously developed IDO1/IDO2 dual inhibitor, guided by homology model structure, we discovered compound 22, most potent inhibitor with good vitro inhibitory activity...
Background: Infantile spasm (IS) is one of the most common catastrophic epilepsy syndromes in infancy. While adrenocorticotropic hormone (ACTH) first-line treatment for IS, it evident that seizures associated with IS exhibit a clear circadian rhythm; however, precise mechanisms underlying such remain unclear. Melatonin an important amine and regulated by rhythm. Circadian proteins, especially BMAL1 CLOCK, their target proteins PER CRY, play key roles This study explored relationships between...
Abstract Although there is growing appreciation for effective repurposing of selective serotonin reuptake inhibitors (SSRIs) cancer therapy, particularly hepatocellular carcinoma (HCC), efforts are hampered by limited knowledge their molecular targets and mechanism action. Global inverse gene-expression profiling method, drug affinity responsive target stability assay, in silico docking analysis was performed to identify the SSRIs. Murine subcutaneous, orthotopic models, patient-derived...
Abstract Emerging evidence suggests white matter network abnormalities in patients with schizophrenia (SZ) and bipolar disorder (BD), but the alterations dynamics of SZ BD are largely unknown. The ( n = 45) 47) that healthy controls (HC, 105) were constructed. We used control theory to quantify metrics network, including controllability synchronizability, measure ability transfer between different states. Experiments show showed decreasing modal synchronizability increasing average...
Spinal muscular atrophy (SMA), a neurodegenerative disorder caused by mutations in survival motor neuron 1 (SMN1) resulting reduced expression of the (SMN) protein, is inherited an autosomal recessive manner. SMA type most frequent subtype characterized onset before 6 months life, inability to achieve independent sitting, and rapidly progressive respiratory bulbar deterioration, causing mortality >90% 2 years age.[1] Currently, there have been two lifelong splice-modifying therapies...
To understand the prevalence of cognitive impairment (CI) in middle-aged and elderly individuals Anhui Province to develop a CI risk prediction model. From May June 2022, multistage, stratified cluster-sampling method was used select 3200 people over 45 years old for questionnaire survey, Chinese version Mini-Mental State Examination (MMSE) assess function. SPSS 25.0 univariate multivariate analyses, R software establish validate nomogram. A total 3059 valid questionnaires were included,...