A5054595087- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Medical Research and Treatments
- Retinal Diseases and Treatments
- Lipid metabolism and disorders
- Pharmacological Effects of Natural Compounds
- Retinal Imaging and Analysis
- Traditional Chinese Medicine Analysis
- Chronic Kidney Disease and Diabetes
- Neurological Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Pain Mechanisms and Treatments
- Diabetes Treatment and Management
- Cytomegalovirus and herpesvirus research
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Acne and Rosacea Treatments and Effects
- Pharmacology and Obesity Treatment
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Cell death mechanisms and regulation
- Pineapple and bromelain studies
- Extracellular vesicles in disease
Guang’anmen Hospital
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
China Academy of Chinese Medical Sciences
2011-2025
Kunming Medical University
2024
Guizhou Provincial People's Hospital
2023-2024
Yan'an Hospital Affiliated To Kunming Medical University
2024
Chinese PLA General Hospital
2024
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Yangzhou University
2016-2021
Background: The gut microbiota plays important roles in the occurrence and development of obesity diabetes through participating nutrient absorption metabolism. Microecological regulation is likely to be key understanding effects Chinese medicine. Linggui Zhugan (LGZG) formula a well-known medicine for controlling clinic. However, its pharmacological mechanism action require further exploration. Objective: To evaluate LGZG on body weight, glycemic control, lipid levels, high-fat diet-induced...
Abstract: Diabetes mellitus (DM) was one of the most severe public health problems that affected nearly 463 million adults around world. In addition to insulin and oral hypoglycemic agents, traditional Chinese medicine (TCM) an effective alternative therapy for diabetes its complications, it had been widely used in Pan-Pacific region, especially Southeast Asia, however, TCM lacked specialized standards care DM past, which limited clinical efficacy diabetes. Since March 2017, Endocrinology...
Diabetes and malignant tumors often lead to abnormal immune function, increasing susceptibility herpes zoster severe post-herpetic neuralgia. Renal insufficiency following renal cell carcinoma surgery can be compounded by treatment with nephrotoxic antiviral drugs. There have also been case reports of occurring at the surgical site. A 68-year-old man developed site neuralgia left nephroureterectomy for kidney clear accompanied postoperative insufficiency. After brivudine, was controlled,...
Background To improve the performance of health care institutions, reduce overmedication, and minimize waste medical resources, China is committed to implementing a clinical pathway management model. This study aims standardize nursing practices, foster thinking in nurses, promote patient recovery. Objective The purpose this evaluate effects traditional Chinese medicine (TCM) program based on pathways for patients with type 2 diabetes mellitus (T2DM). Methods uses prospective, randomized,...
Background Despite advancements, breast cancer outcomes remain stagnant, highlighting the need for precise biomarkers in precision medicine. Traditional TNM staging is insufficient identifying patients who will respond well to treatment. Methods Our study involved over 6,900 from 14 datasets, including in-house clinical data and single-cell 8 (37,451 cells). We integrated 10 machine learning algorithms 55 combinations analyzed 100 existing signatures. IHC assays were conducted validation,...
Banxia xiexin decoction (BXXX) is a classic preparation used to treat gastrointestinal diseases, and also has certain therapeutic effects on tumors. BXXX been reported regulate the expression of proteins associated with drug resistance sensitivity in tumors, thus, aim present study was investigate mechanisms gastric cancer (GC). The levels programmed cell death 1 ligand (PD‑L1), 6‑O‑methylguanine‑DNA methyltransferase (MGMT) STAT3 were immunohistochemically detected adjacent non‑cancer...
Aim . QC4 is the derivative of rosin’s main components dehydroabietic acid (DHA). We investigated cytotoxic effect on gastric cancer cells and revealed mechanisms beneath induction cell death. Methods The was evaluated by CCK-8 assay flow cytometry. underlying were tested administration death related inhibitors detection apoptotic oncosis proteins. Cytomembrane integrity organelles damage confirmed lactate dehydrogenase (LDH) leakage assay, mitochondrial function test, cytosolic free Ca 2+...
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes and remains the leading cause blindness in adults. Retinal inflammation playing crucial role development DR, targeting inflammatory mediators promising strategy for controlling DR. Here, we investigated compound Chinese medicine Luo Tong formula (LTF) alleviated retinal responses STZ-induced diabetic rat model.Sprague-Dawley rats were divided into four groups: control, streptozotocin-induced diabetic, LTF-treated...
Abnormalities in glucose metabolism may be the underlying cause of β-cell dysfunction and identity impairment resulting from high exposure. In China, Coptis deltoidea C. Y. Cheng et Hsiao (YL) has demonstrated remarkable hypoglycemic effects.
Research on the imbalance of proopiomelanocortin (POMC)/agouti-related protein (AgRP) neurons in hypothalamus holds potential insights into pathophysiology diabetes. Jinkui Shenqi pills (JSP), a prevalent traditional Chinese medicine, regulate hypothalamic function and treat To investigate hypoglycemic effect JSP explore probable mechanism treating A type 2 diabetes mouse model was used to pharmacodynamics JSP. The glucose-lowering efficacy assessed through various metrics including body...
To analyze the role of and mechanism underlying obstructive sleep apnea (OSA)-derived exosomes in inducing non-alcoholic fatty liver (NAFLD).
To identify a safe and effective Impaired Glucose Tolerance (IGT) intervention program using Traditional Chinese Medicine (TCM) supported by Standard Health Care Advice (SHCA) for the evidence-based TCM in IGT prevention of type 2 diabetes. A total 510 patients were randomly assigned into either control or group (255 each group). The received standard health care according to SHCA. also addition care. study was conducted over three-year follow-up. At end three years follow-up, accumulative...
Aim: Diabetic retinopathy (DR) is a serious complication of diabetes (DM). Luo Tong formula (LTF) exerts protective effects against DR in rats, but its underlying mechanism remains unknown. Methods : Sprague-Dawley rats injected with streptozotocin (STZ) were used as an experimental model. LTF or calcium dobesilate (CaD) was administered to diabetic via gastric gavage. After the 12 weeks treatment, blood and tissue samples collected determine serum glucose retinal structure. Blood for...
Banxia Xiexin Decoction (BXXD) reportedly regulates glycolipid metabolism and inhibits pancreatic β-cell apoptosis. This study is aimed at investigating the protective effect of BXXD on tert-butyl hydroperoxide- (t-BHP-) induced apoptosis in MIN6 cells underlying mechanisms. were preincubated with or liraglutide (Li) without PI3K inhibitor LY294002 (LY) for 12 h, following which t-BHP was added to induce cell The effects evaluated by detecting viability proliferation glucose-stimulated...
Abstract A correlation exists between obstructive sleep apnoea (OSA) and the severity of metabolic dysfunction-associated steatotic liver disease (MASLD), OSA can induce more severe MASLD. However, underlying regulatory mechanism two is unclear. To this end, study explored role possible molecular mechanisms adipocyte-derived exosomes under in aggravating Through sequencing technology, miR-455-3p was identified as a co-differentially expressed miRNA MASLD + Control groups groups. Upregulation...
To observe the physiological and psychological changing of type 2 diabetic patients after practicing Eight-Section Brocade, to evaluate clinical curative effect, provide a safe effective self-regulating method for patients.This study is random controlled trial, 54 were randomly assigned into intervention control group. The group was given 2-month period Brocade practice, then comparison between groups made. continued do practice months, so it 4 months' all together this group, within...