A5102816486- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Salivary Gland Disorders and Functions
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare and Venom Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Voice and Speech Disorders
- Folate and B Vitamins Research
- Erythropoietin and Anemia Treatment
- Axon Guidance and Neuronal Signaling
- Child Abuse and Trauma
- Nuclear Receptors and Signaling
- Migration, Health and Trauma
- Medicinal Plant Pharmacodynamics Research
- Stroke Rehabilitation and Recovery
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Neurological Disorders and Treatments
- Immune cells in cancer
- Child and Adolescent Health
- Phytochemical compounds biological activities
Capital Medical University
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2020
Guang’anmen Hospital
2020
Shuguang Hospital
2020
Shanghai University of Traditional Chinese Medicine
2020
Xuan Wu Hospital of the Capital Medical University
2010-2012
Ministry of Education of the People's Republic of China
2012
We observed that microRNA-424 (miR-424) significantly decreased in an miRNA profile of circulating lymphocytes patients with ischemic stroke. The present study focused on the potential and mechanism miR-424 protecting brain injury mice. Cerebral ischemia was induced by middle cerebral artery occlusion C57/BL6 infarction volume, neuronal apoptosis, microglia activation were determined 2,3,5-triphenyltetrazolium chloride staining, immunofluorescence, Western blot. BV2 microglial cell activity,...
Abstract: Diabetes mellitus (DM) was one of the most severe public health problems that affected nearly 463 million adults around world. In addition to insulin and oral hypoglycemic agents, traditional Chinese medicine (TCM) an effective alternative therapy for diabetes its complications, it had been widely used in Pan-Pacific region, especially Southeast Asia, however, TCM lacked specialized standards care DM past, which limited clinical efficacy diabetes. Since March 2017, Endocrinology...
Introduction Inflammation is a key driver of adverse outcomes in acute myocardial infarction (AMI), yet current western anti-inflammatory therapies are limited by their single-target nature and side effects. Traditional Chinese medicine (TCM), such as Tanhuo Decoction (THD), offers multi-target, low-toxicity alternative. Methods In randomized controlled trial, AMI patients with high inflammatory responses received either standard Western (WM) alone or combined THD for 3 days. Clinical...
Objectives: This study examines the efficacy of puerarin, a drug used in traditional Chinese medicine, attenuating ischemic brain injury after cerebral ischemia and reperfusion, explores possible mechanisms underlying neuroprotective effects. Methods: The animal model ischemia/reperfusion was induced by middle artery occlusion for 2 hours followed up to 72 hour reperfusion. rats were randomly assigned into four groups (n=6/group): puerarin at 100, 200 400 mg/kg or saline, administered...
The epigenetic study of childhood trauma has become a valuable field. However, the evolution and emerging trends in epigenetics have not been studied by bibliometric methods.This aims to evaluate status studies reveal research based on bibliometrics.A total 1,151 publications related published between 2000 2021 were retrieved from Web Science Core Collection (WoSCC). CiteSpace (5.8. R 3) was used implement analysis visualization.Since 2010, number expanded quickly. United States McGill...
Luoyutong (LYT) capsule has been used to treat cerebrovascular diseases clinically in China and is now patented approved by the State Food Drug Administration. In this retrospective validation study we investigated ability of LYT protect against cerebral ischemia-reperfusion injury rats. Cerebral was induced middle artery occlusion followed reperfusion. Capsule containing (high dose medium dose) as treatment group Citicoline Sodium positive control were administered daily rats 30 min after...
Tanhuo formula (THF), a traditional Chinese medicinal formula, has been demonstrated to be effective in the clinical treatment of acute ischemic stroke (AIS). However, its active ingredients, potential targets, and molecular mechanisms remain unknown. Based on validation ingredient concentrations, our study attempted elucidate possible THF based network pharmacological analysis experimental validation. Components were screened using analysis, compound–target protein–protein interaction (PPI)...
Stroke is characterized by high incidence, recurrence rate, and mortality. Patients with acute ischemic stroke (AIS) who are ineligible for revascularization therapy require more effective medication treatments. A previous clinical study showed that Ruyi Zhenbao tablets Baimai ointments might be against AIS; however, high-quality evidence supporting their application in AIS lacking. To explore the efficacy of two classic Tibetan medicines treatment AIS, a randomized trial will conducted...
Objective To study the role of nitric oxide (NO) in pathogenesis cold nerve injury and to explore its mechanism. Methods Cold model was established rat's sciatic nerve. Consistent intermittent cooling 4℃ for 2 hours were respectively applied nerves. Nerve samples taken at different time points: immediately post-cooling 4 h, 1 d & 3 post-cooling. The group aminoguanidine (AG) intervention also established. Then NO levels nerves blood serum detected. Induced synthase (iNOS) ganglion determined...
To analyze the association between tongue manifestations and levels of glucose (GLU), total cholesterol (TCH), high-density lipoprotein (HDL-C) in subjects with acute cerebral infarction. Hospitalized patients first unilateral infarction Neurological Department Xuanwu Hospital were included correlation fur color, nature, GLU, TCH, HDL-C analyzed. HDL level thin group was higher than that thick (P=0.02). The difference among groups significant (P<0.05), classified terms slippery, moist, dry...
Objective To investigate the morphological changes in sciatic nerve and dorsal root ganglions (DRGs) also gene expression DRGs after non-freezing cold injury, to explore molecular mechanism of peripheral injury regeneration. Methods Twenty-four male Wistar rats were used. The on one side was cooled 4℃ for 2 h, opposite exposed, but without cooling. Sciatic nerves L4, L5 L6 from both sides harvested at 1st, 2nd 3rd week Any pathological observed using light electron microscopy. Laser capture...
A 20-year-old female patient took warfarin regularly at a dose of 3.75 mg once daily for sinus thrombosis and the INR value between 1.50 1.90. Headache was brought under control no bleeding tendency existed. In order to further alleviate symptoms, given decoction traditional Chinese medicine activating blood. On day 4, had epistaxis. next day, started having gingival 2.06. The usage dosage remained unchanged decreased 3.00 mg/d, then did not recur. Eighteen days later, 1.56 any...