A5100348480- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Hearing Loss and Rehabilitation
- Biochemical effects in animals
- Diet and metabolism studies
- Traumatic Brain Injury Research
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
- Chronic Kidney Disease and Diabetes
- Neurosurgical Procedures and Complications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Clinical practice guidelines implementation
- Autophagy in Disease and Therapy
- Spinal Dysraphism and Malformations
- Bacterial Infections and Vaccines
- Biomedical Research and Pathophysiology
- Neurological and metabolic disorders
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Sirtuins and Resveratrol in Medicine
- Parkinson's Disease Mechanisms and Treatments
Guilin Medical University
2017-2024
Children's Hospital of Fudan University
2021-2023
Inner Mongolia Medical University
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Uppsala University Hospital
2017
Abstract Post-stroke acute inhibition of aquaporin 4 (AQP4) is known to exacerbate inflammation and apoptosis, yet the underlying mechanisms are not fully understood. The objective this study was investigate specific mechanism apoptosis following cerebral ischemia–reperfusion (I/R) injury using AQP4-specific inhibitor, N-(1,3,4-thiadiazol-2-yl) pyridine-3-carboxamide dihydrochloride (TGN-020). Ischemic stroke induced in mice middle artery occlusion (MCAO) model. C57/BL6 were randomly divided...
Both glymphatic system dysfunction and inflammatory response aggravate neurological after subarachnoid hemorrhage (SAH). Studies have shown that β-hydroxybutyrate (BHB) may mitigate painful diabetic neuropathy (PDN) by upregulating SNTA1 expression reinstating AQP4 polarity. However, the potential of BHB to ameliorate function in SAH mice remains uncertain.
Limb ischemic postconditioning (LPostC) is an innovative treatment for ischemia/reperfusion injury (IRI). However, its mechanisms have not yet been elucidated. Herein, we assessed the importance of SIRT1/PGC-1α signaling in LPostC neuroprotection following cerebral I/R rats. In this study, used 40 male SD rats that were separated into sham, I/R, LPostC, and + EX-527 (SIRT1 inhibitor) groups (each with 10 rats), a middle artery occlusion (MCAO) model to induce IRI. was induced via three...
Platelet-activating factor (PAF), protein kinase C (PKC)βI, transforming growth (TGF)‑β1 and aberrant extracellular matrix (ECM) deposition have been associated with diabetic nephropathy (DN). However, the mechanistic basis underlying this association remains to be elucidated. The present study investigated among aforementioned factors in a DN model consisting of human mesangial cells (HMCs) exposed high glucose (HG) lysophosphatidylcholine (LPC) treatments. HMCs were divided into following...
Current attempts to regenerate cochlear sensorineural structures motivate further inspection of the human organ hearing. Here, we analyzed supernumerary inner hair cell (sIHC), a possible sign regeneration and replacement.Human cochleae were studied using field emission scanning electron microscopy (FESEM; maximum resolution 2 nm) obtained from individuals aged 44, 48, 58 years with normal pure-tone average (PTA) thresholds (PTA <20 dB). The wasted tissue was harvested during trans-cochlear...
To determine the possible risk factors for post-stroke depression in patients with mild and moderate acute strokes. A cross-sectional descriptive study was conducted involving 129 The were divided into non-depressed stroke groups according to Hamilton Depression Rating Scale Depression-17 item Patient Health Questionnaire-9 assessments. All participants evaluated based on clinical characteristics a battery of scales. Patients had an increased frequency, severe symptoms poor performance...
Congenital hydrocephalus is one of the most common birth defects worldwide. Exosomal microRNAs (miRNAs) in body fluids have been implicated many diseases. However, their involvement cerebrospinal fluid from congenital not well understood. This study aimed at investigating role dysregulated exosomal miRNAs hydrocephalus. We collected samples 15 patients and 21 control subjects. used miRNA sequencing to generate expression profiles three pairs samples. identified 31 differentially expressed...
Delayed neuronal damage can be caused or aggravated after cerebral ischemia-reperfusion (I/R) injury. Recent studies have shown that glymphatic system dysfunction injury is involved in ischemic brain edema and neuroinflammation, thereby regulating The aim of this study to investigate the changes whether limb remote postconditioning (LRIP) improve function protect brain.To establish a focal I/R mouse model, utilized middle artery occlusion/reperfusion (MCAO/R) method. present classified...
Abstract Background and objective The pathogenesis pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remain unclear. Homocysteine may reduce the compliance intracranial arteries damage endothelial function blood-brain barrier (BBB), which be underlying mechanism iNPH. overlap cases between deep perforating arteriopathy (DPA) iNPH were not rare for shared risk factors. We aimed to investigate relationship serum homocysteine in DPA. Methods A total 41 DPA patients with 49...
We aimed to investigate the methodology, results, complications and stereotactic application accuracy of electrode implantation its explanatory variables in stereoelectroencephalography-guided radiofrequency thermocoagulation (SEEG-RFTC) for pediatric hypothalamic hamartoma.Children with hamartoma who underwent robot-assisted SEEG-RFTC between December 2017 November 2021 were retrospectively analyzed. The seizure outcome, complications, vivo analyzed.A total 161 electrodes implanted 28...
Objective To study the role of nitric oxide (NO) in pathogenesis cold nerve injury and to explore its mechanism. Methods Cold model was established rat's sciatic nerve. Consistent intermittent cooling 4℃ for 2 hours were respectively applied nerves. Nerve samples taken at different time points: immediately post-cooling 4 h, 1 d & 3 post-cooling. The group aminoguanidine (AG) intervention also established. Then NO levels nerves blood serum detected. Induced synthase (iNOS) ganglion determined...
Abstract Background The acute inhibition of glymphatic after stroke has been shown to aggravate post-stroke inflammation and apoptosis; however, the related mechanisms remain ambiguous. This study aimed assess specific mechanism apoptosis cerebral ischemia-reperfusion (I/R) injury by improving dysfunction. Materials Methods Ischemic was induced using mice middle artery occlusion (MCAO) model. C57/BL6 were randomly divided into three groups as follows: sham operation, Ischemia-reperfusion 48...