A5077022030- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Meningioma and schwannoma management
- Sinusitis and nasal conditions
- Facial Nerve Paralysis Treatment and Research
- Ion Channels and Receptors
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Trigeminal Neuralgia and Treatments
- Medical Practices and Rehabilitation
- Neuroscience and Neural Engineering
- Vascular Malformations Diagnosis and Treatment
- Tracheal and airway disorders
- Nerve injury and regeneration
- PARP inhibition in cancer therapy
- Ion Transport and Channel Regulation
- Pediatric health and respiratory diseases
- vaccines and immunoinformatics approaches
- Neurogenesis and neuroplasticity mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Voice and Speech Disorders
- Peptidase Inhibition and Analysis
- Retinal Development and Disorders
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2004-2025
University of Tübingen
2015-2024
Universitätsklinikum Tübingen
2005-2024
University Children's Hospital Tübingen
2012-2024
Bernstein Center for Computational Neuroscience Tübingen
1994-2023
Universitäts-HNO-Klinik Heidelberg
1995-2022
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2005-2020
Medical University of Vienna
1997-2019
Carl von Ossietzky Universität Oldenburg
2014-2017
Innsbruck Medical University
2017
Hearing loss is most often the result of hair-cell degeneration due to genetic abnormalities or ototoxic and traumatic insults. In postembryonic adult mammalian auditory sensory epithelium, organ Corti, no regeneration has ever been observed. However, nonmammalian epithelia are capable regenerating hair cells as a consequence nonsensory supporting-cell proliferation. The supporting Corti highly specialized, terminally differentiated cell types that apparently incapable At molecular level...
Abstract Objectives: To study the safety and efficacy of continuous intratympanic dexamethasone‐phosphate (Dex‐P) for severe to profound sudden idiopathic sensorineural hearing (ISSHL) or anacusis after failure systemic therapy. Study Design: Randomized, double‐blind, placebo controlled multicenter trial. Methods: Patients with ISSHL insufficient recovery (mean 4PTA = 97 dB HL) high dose glucocorticoid therapy received either Dex‐P (4mg/ml) (NaCl 0.9%) continuously applied 14 days into round...
For nearly 3 years, the monoclonal antibody dupilumab has been approved in Germany for treatment of patients with chronic rhinosinusitis nasal polyps (CRSwNP). Although efficacy demonstrated large double-blind, placebo-controlled clinical trials, few reports real-world data on this therapy have published to date.Patients an indication CRSwNP were included study and followed up every months a period 1 year. At baseline visit, demographic data, medical history, comorbidities, polyp score,...
Abstract Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), adults mild-moderate sensorineural loss received 3 intratympanic injections GSI LY3056480, in 1 ear over 2 weeks. I primary outcome was safety tolerability. lla change from baseline to 12 weeks average pure-tone air conduction threshold across...
The variability in outcomes of cochlear implantation is largely unexplained, and clinical factors are not sufficient for predicting performance. Genetic have been suggested to impact outcomes, but the genetic heterogeneity hereditary hearing loss makes it difficult determine interpret postoperative It hypothesized that mutations affect neuronal components cochlea auditory pathway, targeted by implant (CI), may lead poor A large cohort CI recipients was studied verify this hypothesis.This...
Abstract T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is central for cancer immune surveillance. Mass spectrometry (MS)-based immunopeptidomics represents the only unbiased method direct identification and characterization naturally presented peptides, a key prerequisite development cell-based immunotherapies. This study reports on implementation ion mobility separation-based time-of-flight (TOF IMS ) MS next-generation immunopeptidomics, enabling...
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases affecting photoreceptors and causing blindness in humans. Previously, excessive activation enzymes belonging to the poly-ADP-ribose polymerase (PARP) was shown be involved photoreceptor degeneration human homologous rd1 mouse model for RP. Since there are at least 16 different PARP isoforms, we investigated exact relevance predominant isoform - PARP1 cell death using knock-out (KO) mice. In vivo ex morphological...
Spread of antimicrobial resistance and shortage novel antibiotics have led to an urgent need for new antibacterials. Although aminoglycoside (AGs) are very potent anti-infectives, their use is largely restricted due serious side-effects, mainly nephrotoxicity ototoxicity. We evaluated the ototoxicity various AGs selected from a larger set on basis strong antibacterial activities against multidrug-resistant clinical isolates ESKAPE panel: gentamicin, gentamicin C1a, apramycin, paromomycin...
Objective To investigate whether one of the two recently described MD endotypes—defined by either endolymphatic sac degeneration (MD-dg patients) or hypoplasia (MD-hp patients)—is associated with an increased likelihood undergoing CI. Study Design Retrospective multicenter cross-sectional study. Setting Five tertiary referral centers. Patients CI cohort: 115 adult patients a history uni- bilateral Non-CI 72 no history. All included matched current diagnostic criteria for definite MD....
Human auditory nerve afferents consist of two separate systems; one is represented by the large type I cells innervating inner hair and other small II outer cells. Type spiral ganglion neurons (SGNs) constitute 96% afferent population and, in contrast to mammals, their soma pre- post-somatic segments are unmyelinated. fibers Histopathology clinical experience imply that human SGNs can persist electrically excitable without dendrites, thus lacking connection organ Corti. The biological...
Morphologic criteria for the diagnosis of primary and recurrent inverted papilloma as revealed on CT were evaluated in a large series. Findings 121 examinations that had been performed 32 patients with histologically proven retrospectively analyzed using following morphologic criteria: localization, size, surface configuration, bony changes. Unilateral tumor localization involving lateral nasal wall middle meatus was feature best correlated finding papilloma. A lobulated pattern another...
Objectives: Hereditary hearing loss exhibits high degrees of genetic and clinical heterogeneity. To elucidate the population-specific age-related spectra hereditary loss, we investigated sequencing data causally associated genes in a large cohort hearing-impaired probands with balanced age distribution from single center Southwest Germany. Design: Genetic testing was applied to 305 probands/families suspected etiology over period 8 years (2011–2018). These individuals were representative...
Neurotrophins promote neurite outgrowth of auditory neurons and may help closing the gap to cochlear implant (CI) electrodes enhance electrical hearing. The best concentrations mix neurotrophins for this nerve regrowth are unknown. Whether stimulation (ES) during is beneficial or direct axons another open question. Auditory neuron explant cultures distinct turns 6–7 days old mice were cultured four days. We tested different combinations BDNF NT-3 quantified numbers lengths neurites with an...
Despite its invasiveness, the temporary implantation of a microcatheter into middle ear cavity is an appropriately safe method for providing continuous drug delivery to inner ear.For application drugs ear, different strategies are available ranging from intratympanic injections temporarily implanted microcatheters. It has recently been demonstrated that choice system influences pharmacokinetics in ear. If over several weeks required, secure placement device (i.e., microcatheter) necessary...
Mutations in the large <i>GPR98</i> gene underlie Usher syndrome type 2C (USH2C), and all patients described to date have been female. It was speculated that mutations cause a more severe, eventually lethal, phenotype males. We describe for first time two male with USH2 novel mutations. Clinical characterization of patient his affected sister revealed typical both. may excluded from systematic investigation previous studies, proportion USH2C probably underestimated. should be considered both sexes.
Since the classical description by Retzius in 1884, many extensive studies of micro-anatomy human cochlea have been presented. The is one most difficult tissues to study due bony capsule and its delicate contents. Most preparations suffer from post-mortem changes caused delay between demise fixation. For over a decade, we analyzed inner-ear tissue obtained at surgery using transmission electron microscopy, scanning vitro culture, immunohistochemistry. These show value these techniques for...