A5019070287- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Music Perception
- Ear Surgery and Otitis Media
- Tendon Structure and Treatment
- Respiratory and Cough-Related Research
- Veterinary Equine Medical Research
- Fetal and Pediatric Neurological Disorders
- Thyroid Disorders and Treatments
- Advanced MRI Techniques and Applications
- Child Development and Digital Technology
- Early Childhood Education and Development
- Shoulder Injury and Treatment
University College London
2019-2024
Royal Berkshire NHS Foundation Trust
2019-2024
National Institute for Health Research
2024
The Ohio State University
2023
Great Ormond Street Hospital
2019-2022
Abstract Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), adults mild-moderate sensorineural loss received 3 intratympanic injections GSI LY3056480, in 1 ear over 2 weeks. I primary outcome was safety tolerability. lla change from baseline to 12 weeks average pure-tone air conduction threshold across...
This study assessed white matter microstructural integrity and behavioral correlates for children with severe congenital hypothyroidism (CH) who were identified treated early following newborn screening. Eighteen CH 21 healthy controls underwent a battery of measures hearing, language communication, along diffusion MR imaging. Tract-based spatial statistics performed on standard parameters fractional anisotropy diffusivity metrics. Microscopic mapping based the Spherical Mean Technique was...
Abstract Introduction Auditory neuropathy spectrum disorder (ANSD) is a term for collection of test results which indicate disruption the auditory signal at some point along neural pathway. This in functional outcomes, ranging from reasonably normal hearing to profound loss. study assessed brain structure changes and behavioral correlates children diagnosed with ANSD. Methods Seventeen who had previously been ANSD were recruited underwent battery measures hearing, language, communication,...
The objectives of this study were to describe, analyse and compare the sound environments which deaf typically hearing children between 3 18 months are exposed, identify issues support development guidelines for use radio aids in age group. Thirty parents aged 3–18 (14 16 who hearing) took part. An online survey was devised intended capture "soundscape" (sounds environment) both usually exposed their everyday lives at multiple points during day. purpose map routine experiences interactions...
Abstract OBJECTIVE To investigate matrix metalloproteinase (MMP) and their inhibitors tissue inhibitor (TIMP) gene expression secretion during equine deep digital flexor tendon (DDFT) tenocyte macrophage (undifferentiated, proinflammatory, regulatory) co-culture. SAMPLE Third passage DDF tenocytes donor-matched macrophages differentiated from peripheral blood CD14 + monocytes 5 healthy horses ages 9–11 years, euthanized for reasons unrelated to musculoskeletal conditions. METHODS Passage 3...
The objective of this study was to establish whether autoinflation an effective intervention in a paediatric audiology service. This pragmatic retrospective with historical controls using paired availability design.The took place at single service England.All children seen the clinic over two-year period who were aged between 3 and 11 years had type B tympanogram least one ear included. Otovent device available as treatment option second year (Cohort B) but not first A). There 976 included...