A5101476888- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
National and Kapodistrian University of Athens
2024-2025
Hippocration General Hospital
2024-2025
Abstract Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa multiple-ascending dose open-label trial (ISRCTN59733689), adults mild-moderate sensorineural loss received 3 intratympanic injections GSI LY3056480, in 1 ear over 2 weeks. I primary outcome was safety tolerability. lla change from baseline to 12 weeks average pure-tone air conduction threshold across...
Objectives: Hearing aids (HAs) are a widely accepted first-line treatment option for individuals suffering from both hearing loss and chronic tinnitus. Though HAs highly effective at improving speech understanding, their effectiveness in ameliorating tinnitus symptoms is less clear. In recent years, several investigators have reported on attempts to predict using an array of variables. These included attributes (e.g., frequency, loudness, character), audiological characteristics degree...
Background: This study investigates electrophysiological distinctions in auditory evoked potentials (AEPs) among individuals with chronic subjective tinnitus, a specific focus on the impact of treatment response and tinnitus localisation. Methods: Early AEPs, known as Auditory Brainstem Responses (ABR), middle termed Middle Latency (AMLR), were analysed patients across four clinical centers an attempt to verify increased neuronal activity, accordance current models. Our statistical analyses...
Abstract Tinnitus is associated with a variety of aetiologies, phenotypes, and underlying pathophysiological mechanisms, available treatments have limited efficacy. A combination treatments, addressing various aspects tinnitus, might provide viable superior treatment strategy. In this international multicentre, parallel-arm, superiority, randomised controlled trial, patients chronic subjective tinnitus were recruited from five clinical sites across the EU as part interdisciplinary...