A5058089359- Digital Mental Health Interventions
- Mobile Health and mHealth Applications
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Mental Health Research Topics
- COVID-19 and Mental Health
- Behavioral Health and Interventions
- Noise Effects and Management
- COVID-19 Digital Contact Tracing
- Orthopedic Infections and Treatments
- Phonocardiography and Auscultation Techniques
- Innovation Policy and R&D
- Bone fractures and treatments
- Intellectual Property and Patents
- Global trade and economics
- Orthopaedic implants and arthroplasty
- Sports Science and Education
- Digital Innovation in Industries
- Vestibular and auditory disorders
- Trauma Management and Diagnosis
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Prosthetics and Rehabilitation Robotics
- Angiogenesis and VEGF in Cancer
- Cancer-related cognitive impairment studies
University of Würzburg
2019-2024
Universitätsklinikum Würzburg
2021-2024
Zimmer Biomet (Germany)
2020-2024
Essen University Hospital
2021-2022
Ruhrlandklinik
2022
University of Duisburg-Essen
2021
Bausch Health (Germany)
2015
Max Planck Institute for Heart and Lung Research
2007
Physical and mental well-being during the COVID-19 pandemic is typically assessed via surveys, which might make it difficult to conduct longitudinal studies lead data suffering from recall bias. Ecological momentary assessment (EMA) driven smartphone apps can help alleviate such issues, allowing for in situ recordings. Implementing an app not trivial, necessitates strict regulatory legal requirements, requires short development cycles appropriately react abrupt changes pandemic. Based on...
Vascular endothelial growth factor (VEGF), a potent mediator of proliferation and migration, has an important role also in brain edema formation during hypoxia ischemia. VEGF binds to the tyrosine kinase receptors Flt-1 Flk-1. Yet, their relative importance for hypoxia-induced hyperpermeability is not well understood. We used vitro blood-brain barrier (BBB) model consisting porcine microvascular cells (BMEC) determine VEGF-induced cell (EC) dysfunction. Soluble abolished hypoxia/VEGF-induced...
Zusammenfassung Hintergrund Die tatsächliche Anzahl verunglückter E‑Scooter-Fahrer in Deutschland scheint deutlich höher zu sein, als es die aktuellen Zahlen des Statistischen Bundesamtes vermuten lassen. Diese epidemiologische Studie untersucht E‑Scooter-Verletzungen und vergleicht diese mit E‑Bike- Fahrradverletzungen. Fragestellung Zur Schaffung einer vergleichbaren Datenlage über Gefahren von E‑Scootern, E‑Bikes Fahrrädern wurden typischen Verletzungsmuster analysiert daraus...
The aim of this study was to investigate the impact different coping styles on situational in everyday life situations and gender differences. An ecological momentary assessment with mobile health app TrackYourStress conducted 113 participants. Positive Thinking, Active Stress Coping, Social Support, Support Faith, Alcohol Cigarette Consumption Coping Inventory were measured at baseline. Situational assessed by question "How well can you cope your stress level" over 4 weeks. Multilevel...
Abstract Tinnitus is associated with a variety of aetiologies, phenotypes, and underlying pathophysiological mechanisms, available treatments have limited efficacy. A combination treatments, addressing various aspects tinnitus, might provide viable superior treatment strategy. In this international multicentre, parallel-arm, superiority, randomised controlled trial, patients chronic subjective tinnitus were recruited from five clinical sites across the EU as part interdisciplinary...
Abstract. Introduction: The goals of osteomyelitis therapy are successful control infection and reconstruction the bone. gold standard for filling defects is autologous bone graft. Bioactive glass S53P4 an inorganic substitute. We compared outcome using bioactive (BAG) versus graft (AB) in patients with infected non-union. Methods: Patients chronic non-union who received either or grafts between 2013 2017 were analyzed retrospectively. primary endpoint was during follow-up. Secondary...
More and more observational studies exploit the achievements of mobile technology to ease overall implementation procedure. Many strategies like digital phenotyping, ecological momentary assessments or crowdsensing are used in this context. Recently, an increasing number intervention makes use as well. For chronic disorder tinnitus, only few long-running exist, which a larger setting. Tinnitus is characterized by its heterogeneous patient's symptom profiles, complicates development general...
Through lockdowns and other severe changes to daily life, almost everyone is affected by the COVID-19 pandemic. Scientists medical doctors are - among others mainly interested in researching, monitoring, improving physical mental health of general population. Mobile apps (mHealth), conducting ecological momentary assessments (EMA) respectively, can help this context. However, developing such mobile applications poses many challenges like costly software development efforts, strict privacy...
Tinnitus affects a considerable part of the population and develops into severe disorder in some sufferers. App-based interventions are able to provide low-threshold, cost-effective, location-independent care for tinnitus patients. Therefore, we developed smartphone app combining structured counseling with sound therapy conducted pilot study evaluate treatment compliance symptom improvement (trial registration: DRKS00030007). Outcome variables were Ecological Momentary Assessment (EMA)...
At the beginning of COVID-19 pandemic, with a lack knowledge about novel virus and widely available tests, getting first feedback being infected was not easy. To support all citizens in this respect, we developed mobile health app Corona Check. Based on self-reported questionnaire symptoms contact history, users get possible corona infection advice what to do. We Check based our existing software framework released Google Play Apple App Store April 4, 2020. Until October 30, 2021, collected...
Abstract Background Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction tinnitus distress; however, little known about potentially increased effectiveness combination treatments and personalized each patient. Methods Within Unification Treatments Interventions Patients project, multicenter, randomized clinical trial conducted with aim to compare single combined on distress (UNITI-RCT). Five different centers...
A growing number of observational studies are utilizing the advances mobile technology. In addition to diverse strategies such as digital phenotyping, ecological momentary assessments (EMA) or Crowdsensing, intervention becoming increasingly relevant in this context. More specifically, Just-in-Time Adaptive Interventions (JITAIs) appear be a key component health for behavioral support, aimed at providing proper kind aid right time by dynamically adapting person's changing condition. Fully...
The number of mechanical degrees freedom (DoFs) within rehabilitation robots directly influences the scope movements that a subject can perform when training walking. Currently, gait have limited DoFs, as consequence this limits these make possible. In paper, novel system CORBYS is presented which consists mobile platform and powered orthosis attached to platform. has 16 DoFs enabling more physiological movements, making it state-of-the-art robotic system. With sufficient enable natural-like...
The usage of mobile applications in healthcare is gaining popularity recent years. ubiquity a sophisticated appliance that applicable to sample ecological patient data real life by acquiring both mental state and environmental has enabled new possibilities for researchers providers. Collecting using the mentioned approach often called Ecological Momentary Assessment (EMA) characterized an unidirectional flow towards platform provider. A more challenging approach, turn, Intervention (EMI)....
Mobile health technologies have become more and important in psychotherapy research practice. The market is being flooded by several psychotherapeutic online services for different purposes. However, mobile are particularly suitable data collection monitoring, as can be recorded economically real time. Currently, there no appropriate method to assess intersession experiences systematically aim of our project was the development a smartphone application framework systematic recording...
The COVID-19 pandemic is challenging healthcare systems worldwide. This study examines geriatric patients with proximal femur fractures during the pandemic, shifts in secondary disease profile, impact of on hospitalization and further treatment.In a retrospective monocentric study, treated first six months 2020 were analyzed compared same period 2019. Pre-traumatic status (living care home, under supervision legal guardian), type trauma, accident mechanism, risk factors, associated...
Abstract Background The risk of breast cancer patients for long-term side effects therapy such as neurotoxicity and cardiotoxicity well late regarding comorbidities varies from individual to individual. Personalised follow-up care concepts that are tailored needs the recurrences, lacking in routine Germany. Methods We describe methodology BETTER-CARE, a parallel-arm cluster-randomised controlled trial conducted at 15 intervention control centres, aiming recruit 1140 patients, results pilot...
Abstract Background Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction tinnitus distress; however, little known about potential increased effectiveness combination treatments and personalized each patient. Methods Within Unification Treatments Interventions Patients project, multicenter, randomized clinical trial conducted with aim to compare single combined on distress (UNITI-RCT). Five different centers...
Smartphones and other mobile devices offer a valu-able opportunity to gather patient-specific health data during everyday life. However, the increasing popularity of apps demands specialized analysis methods that can handle unique, patient-based, time-dependent, often multivariate collected by these apps. This work explores patient-based mHealth develop personalized prediction models. The models incor-porate not only from individual patient, but also similar patients using neighborhoods. Our...