A5060790199- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Behavioral Health and Interventions
- Cognitive Abilities and Testing
- Attention Deficit Hyperactivity Disorder
- Eating Disorders and Behaviors
- Digital Mental Health Interventions
- Neuroscience and Music Perception
- Obsessive-Compulsive Spectrum Disorders
- Creativity in Education and Neuroscience
- Substance Abuse Treatment and Outcomes
- Memory and Neural Mechanisms
- Decision-Making and Behavioral Economics
- Advanced MRI Techniques and Applications
- COVID-19 and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Mind wandering and attention
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Mental Health Treatment and Access
TU Dresden
2019-2025
Universitätsklinikum Würzburg
2021-2025
Max Planck Institute for Human Cognitive and Brain Sciences
2015-2024
University of Würzburg
2020-2024
Hebrew University of Jerusalem
2024
Social Neuroscience Lab
2024
IFB Adiposity Diseases
2019-2024
Leipzig University
2016-2024
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie
2023
University Hospital Carl Gustav Carus
2023
Subjects with schizophrenia are impaired at reinforcement-driven reversal learning from as early their first episode. The neurobiological basis of this deficit is unknown. We obtained behavioral and fMRI data in 24 unmedicated, primarily episode, patients age-, IQ- gender-matched healthy controls during a task. supplemented our analysis, focusing on prediction errors, detailed computational modeling to probe task solving strategy including an ability deploy internal goal directed model the...
Significance Whether humans make choices based on a deliberative “model-based” or reflexive “model-free” system of behavioral control remains an ongoing topic research. Dopamine is implicated in motivational drive as well planning future actions. Here, we demonstrate that higher presynaptic dopamine human ventral striatum associated with more pronounced model-based control, enhanced coding signatures lateral prefrontal cortex and diminished model-free learning signals striatum. Our study...
In recent years, there has been increasing interest in research on geographical variation the incidence of schizophrenia and other psychoses. this paper, we review evidence psychoses terms place, as well individual- area-level factors that account for variation. We further findings potential mechanisms link adverse urban environment psychosis. There is from earlier more studies urbanicity associated with an increased non-affective addition, considerable across neighbourhoods observed these...
Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone estradiol might reduce or increase alcohol intake, respectively. However, there is need for better understanding of how the menstrual cycle in females ratio to males influence patterns individuals with AUD.
The neural mechanisms behind cognitive deficits in schizophrenia still remain unclear. Functional neuroimaging studies on working memory (WM) yielded inconsistent results, suggesting task performance as a moderating variable of prefrontal activation. Beyond regional specific activation, disordered integration brain regions was supposed critical pathophysiological mechanism schizophrenia. Here, we first hypothesized that activation implicated WM depends primarily and therefore stratified...
<b><i>Background:</i></b> Human and animal work suggests a shift from goal-directed to habitual decision-making in addiction. However, the evidence for this human alcohol dependence is as yet inconclusive. <b><i>Methods:</i></b> Twenty-six healthy controls 26 recently detoxified alcohol-dependent patients underwent behavioral testing with 2-step task designed disentangle response patterns. <b><i>Results:</i></b>...
Task-based measures that capture neurocognitive processes can help bridge the gap between brain and behavior. To transfer tasks to clinical application, reliability is a crucial benchmark because it imposes an upper bound potential correlations with other variables (e.g., symptom or data). However, of many task readouts low. In this study, we scrutinized retest probabilistic reversal learning (PRLT) frequently used characterize cognitive flexibility in psychiatric populations. We analyzed...
Abstract Substance use disorders (SUDs) are seen as a continuum ranging from goal‐directed and hedonic drug to loss of control over intake with aversive consequences for mental physical health social functioning. The main goals our interdisciplinary German collaborative research centre on Losing Regaining Control Drug Intake (ReCoDe) (i) study triggers (drug cues, stressors, priming) modifying factors (age, gender, activity, cognitive functions, childhood adversity, factors, such loneliness...
Background Advancing evidence-based, tailored interventions for substance use disorders (SUDs) requires understanding temporal directionality while upholding ecological validity. Previous studies identified loneliness and craving as pivotal factors associated with alcohol consumption, yet the precise of these relationships remains ambiguous. Objective This study aims to establish a smartphone-based real-life intervention platform that integrates momentary assessment into everyday life. The...
Abstract Fluid intelligence represents the capacity for flexible problem solving and rapid behavioral adaptation. Rewards drive adaptation, in part via a teaching signal expressed as reward prediction errors ventral striatum, which has been associated with phasic dopamine release animal studies. We examined sample of 28 healthy male adults using multimodal imaging biological parametric mapping (1) functional magnetic resonance during reversal learning task (2) subsample 17 subjects also...
Addicted individuals continue substance use despite the knowledge of harmful consequences and often report having no choice but to consume. Computational psychiatry accounts have linked this clinical observation difficulties in making flexible goal-directed decisions dynamic environments via consideration potential alternative choices. To probe alcohol-dependent patients ( n = 43) versus healthy volunteers 35), human participants performed an anticorrelated decision-making task during...
Background. A dysfunctional differentiation between self-relevant and irrelevant information may affect the perception of environmental stimuli as abnormally salient. The aberrant salience hypothesis assumes that positive symptoms arise from an attribution to accompanied by feeling self-relevance. Self-referential processing relies on activation cortical midline structures which was demonstrated be impaired in psychosis. We investigated neural correlates self-referential processing,...
In experimental psychology different experiments have been developed to assess goal–directed as compared habitual control over instrumental decisions. Similar animal studies selective devaluation procedures used. More recently sequential decision-making tasks designed the degree of goal-directed versus choice behavior in terms an influential computational theory model-based model-free behavioral control. As suggested, measurements are thought reflect same construct. Yet, there has no attempt...
Abstract High impulsivity is an important risk factor for addiction with evidence from endophenotype studies. In addiction, behavioral control shifted toward the habitual end. Habitual can be described by retrospective updating of reward expectations in ‘model-free’ temporal-difference algorithms. Goal-directed relies on prospective consideration actions and their outcomes, which captured forward-planning ‘model-based’ So far, no studies have examined neural signatures model-free model-based...
Abstract Consuming more energy than is expended may reflect a failure of control over eating behaviour in obesity. Behavioural arises from balance between two dissociable strategies reinforcement learning: model-free and model-based. We hypothesized that weight status relates to an imbalance reliance on model-based control, it do so linear or quadratic manner. To test this, 90 healthy participants wide BMI range [normal-weight (n = 31), overweight 29), obese 30)] performed sequential...
Theoretical and animal work has proposed that prefrontal cortex (PFC) glutamate inhibits dopaminergic inputs to the ventral striatum (VS) indirectly, whereas direct VS glutamatergic afferents have been suggested enhance VS. In present study, we aimed investigate relationships of dopamine measures in prefrontostriatal circuitries healthy humans. We hypothesized PFC glutamate, as well their balance, are differently associated with dopamine. Glutamate concentrations left lateral were assessed...