A5041521267- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Behavioral Health and Interventions
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Menstrual Health and Disorders
- Sex and Gender in Healthcare
- Receptor Mechanisms and Signaling
- Substance Abuse Treatment and Outcomes
- Impact of Technology on Adolescents
- Resilience and Mental Health
- Ovarian function and disorders
- Treatment of Major Depression
- Homelessness and Social Issues
- Nuclear Receptors and Signaling
- Traumatic Brain Injury Research
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Alcohol Consumption and Health Effects
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
Charité - Universitätsmedizin Berlin
2017-2024
TU Dresden
2022-2024
Humboldt-Universität zu Berlin
2019-2023
Freie Universität Berlin
2019-2023
Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone estradiol might reduce or increase alcohol intake, respectively. However, there is need for better understanding of how the menstrual cycle in females ratio to males influence patterns individuals with AUD.
Abstract Appetitive Pavlovian conditioning is a learning mechanism of fundamental biological and pathophysiological significance. Nonetheless, its exploration in humans remains sparse, which partly attributed to the lack an established psychophysiological parameter that aptly represents conditioned responding. This study evaluated pupil diameter other ocular response measures (gaze dwelling time, blink duration count) as indices conditioning. Additionally, model was used infer participants’...
Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic AC need be informed by real-world evidence.To examine whether lockdown measures are associated with consumption-related temporal psychological within-person mechanisms.This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites February 20, 2020, 28, 2021. Data were provided before within second in Germany: (October...
Self-regulation, the ability to guide behavior according one's goals, plays an integral role in understanding loss of control over unwanted behaviors, for example alcohol use disorder (AUD). Yet, experimental tasks that measure processes underlying self-regulation are not easy deploy contexts where such behaviors usually occur, namely outside laboratory, and clinical populations as people with AUD. Moreover, lab-based have been criticized poor test-retest reliability lack construct validity....
Abstract Learning accounts of addiction and obesity emphasize the persistent power Pavlovian reward cues to trigger craving increase relapse risk. While extinction can reduce conditioned responding, phenomena—the return responding following successful extinction—challenge long-term success extinction-based treatments. Translational laboratory models could therefore represent a valuable tool investigate mechanisms mediating relapse, although so far human research has mostly focused on fear...
Abstract Purpose of Review Current theories alcohol use disorders (AUD) highlight the importance Pavlovian and instrumental learning processes mainly based on preclinical animal studies. Here, we summarize available evidence for alterations those in human participants with AUD a focus habitual versus goal-directed learning, conditioning, Pavlovian-to-instrumental transfer (PIT) paradigms. Recent Findings The balance between control has been studied using outcome devaluation or sequential...
The emergence of Pavlovian-to-instrumental transfer (PIT) research in the human neurobehavioral domain has been met with increased interest over past two decades. A variety PIT tasks were developed during this time; while successful demonstrating phenomena, existing have limitations that should be addressed. Herein, we introduce paradigms designed to assess outcome-specific and general within context addiction.The single-lever task, based on an established paradigm, replaced button presses...
Abstract Behavioural adaptation is a fundamental cognitive ability, ensuring survival by allowing for flexible adjustment to changing environments. In laboratory settings, behavioural can be measured with reversal learning paradigms requiring agents adjust reward stimulus–action–outcome contingency changes. Stress found alter flexibility of learning, but effect directionality mixed across studies. Here, we used model‐based functional MRI (fMRI) in within‐subjects design investigate the acute...
Contemporary learning theories of drug addiction ascribe a key role to Pavlovian mechanisms in the development, maintenance, and relapse addiction. In fact, cue-reactivity research has demonstrated power alcohol-associated cues activate brain's reward system, which been linked craving subsequent relapse. However, whether de novo conditioning is altered alcohol use disorder (AUD) rarely investigated.
Theories of addiction posit a deficit in goal-directed behavior and an increased propensity towards habitual actions individuals with substance use disorders. Control over drug intake is assumed to shift from automatic or motivation as the disorder progresses. Several diagnostic criteria reflect inability pursue goals regarding reducing controlling performing social occupational functions. The current review gives overview mechanisms underlying systems humans, existing paradigms that aim...
Self-regulation, the ability to guide behavior according one’s goals, plays an integral role in understanding loss of control behaviors a pertinent example being substance use disorders (SUD). Yet, experimental tasks that measure processes underlying self-regulation are not easy deploy contexts where such often occur, namely real life situations outside laboratory. Moreover, lab-based criticized for poor test–retest reliability and lack construct validity. These concerns might part explain...
Abstract Background Alcohol use disorder (AUD) is a critical public health issue with sex-specific characteristics and the need for better mechanistic understanding. Initial evidence suggests that progesterone can reduce alcohol intake, while estradiol leads to an increase. However, we lack knowledge about how relative influences patterns in females males AUD. Methods This multicenter within-subject study analyzed data on real-life (21,438 intensively-sampled smartphone entries), menstrual...