A5037908665- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Visual perception and processing mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Smoking Behavior and Cessation
- Advanced Chemical Sensor Technologies
- Transcranial Magnetic Stimulation Studies
- Treatment of Major Depression
- Olfactory and Sensory Function Studies
- Multiple Sclerosis Research Studies
- Psychosomatic Disorders and Their Treatments
- Nicotinic Acetylcholine Receptors Study
- Digital Innovation in Industries
- Intensive Care Unit Cognitive Disorders
- Deception detection and forensic psychology
- Behavioral Health and Interventions
- Health, Environment, Cognitive Aging
- Aesthetic Perception and Analysis
Charité - Universitätsmedizin Berlin
2015-2024
Robert Koch Institute
2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2023
Humboldt-Universität zu Berlin
2016-2023
Freie Universität Berlin
2019-2023
Bernstein Center for Computational Neuroscience Berlin
2017
Radboud University Nijmegen
2014
Objective: In alcohol-dependent patients, alcohol cues evoke increased activation in mesolimbic brain areas, such as the nucleus accumbens and amygdala. Moreover, patients show an approach bias, a tendency to more quickly than avoid cues. Cognitive bias modification training, which aims retrain biases, has been shown reduce craving relapse rates. The authors investigated effects of this training on cue reactivity patients. Method: double-blind randomized design, 32 abstinent received either...
In bistable vision, subjective perception wavers between two interpretations of a constant ambiguous stimulus. This dissociation conscious and sensory stimulation has motivated various empirical studies on the neural correlates perception, but neurocomputational mechanism behind endogenous perceptual transitions remained elusive. Here, we recurred to generic Bayesian framework predictive coding devised model that casts as consequence prediction errors emerging from residual evidence for...
In the search for neural correlates of consciousness, it has remained controversial whether prefrontal cortex determines what is consciously experienced or, alternatively, serves only complementary functions, such as introspection or action. Here, we provide converging evidence from computational modeling and two functional magnetic resonance imaging experiments that indicated a key role inferior frontal in detecting perceptual conflicts caused by ambiguous sensory information. Crucially,...
There is accumulating evidence that automatic processes play a large role in alcohol dependence, which may be related to craving and consumption. The aim of this study investigate associations between cognitive biases alcohol-dependent patients, how these measures relate drinking behavior. Thirty patients 15 healthy controls (matched for age, intelligence education; all male) completed three bias tasks: the Implicit Association Test (IAT: alcohol-approach association), Approach Avoidance...
Perceptual inference depends on an optimal integration of current sensory evidence with prior beliefs about the environment. Alterations this process have been related to emergence positive symptoms in schizophrenia. However, it has remained unclear whether delusions and hallucinations arise from increased or decreased weighting relative evidence. To investigate relation prior-to-likelihood ratio schizophrenia, we devised a novel experimental paradigm which gradually manipulates perceptually...
Predictive coding theories state an aberrant weighting of prior beliefs and present sensory information as a core computational pathology in psychosis. Specifically, it has been proposed that the influence which attenuate improbable is weakened, resulting overweighing this potentially misleading information. However, currently unclear whether alteration specific to perceptual processes or represents more pervasive deficit extends cognitive processes. Here, we carried out 2 behavioral...
Sensory information is inherently noisy, sparse, and ambiguous. In contrast, visual experience usually clear, detailed, stable. Bayesian theories of perception resolve this discrepancy by assuming that prior knowledge about the causes underlying sensory stimulation actively shapes perceptual decisions. The CNS believed to entertain a generative model aligned dynamic changes in hierarchical states our volatile environment. Here, we used model-based fMRI study neural correlates updating...
Perception is known to cycle through periods of enhanced and reduced sensitivity external information. Here, we asked whether such slow fluctuations arise as a noise-related epiphenomenon limited processing capacity or, alternatively, represent structured mechanism perceptual inference. Using 2 large-scale datasets, found that humans mice alternate between externally internally oriented modes sensory analysis. During mode, perception aligns more closely with the information, whereas internal...
With promising results in recent treatment trials for Alzheimer's disease (AD), it becomes increasingly important to distinguish AD at early stages from other causes cognitive impairment. However, existing diagnostic methods are either invasive (lumbar punctures, PET) or inaccurate Magnetic Resonance Imaging (MRI). This study investigates the potential of neuropsychological testing (NPT) specifically identify those patients with possible among a sample 158 Mild Cognitive Impairment (MCI)...
According to the predictive coding theory of psychosis, hallucinations and delusions are explained by an overweighing high-level prior expectations relative sensory information that leads false perceptions meaningful signals. However, it is currently unclear whether hypothesized priors (1) represents a pervasive alteration extends visual modality (2) takes already effect at early automatic processing stages. Here, we addressed these questions studying perception socially stimuli in healthy...
Alcohol consumption (AC) leads to death and disability worldwide. Ongoing discussions on potential negative effects of the COVID-19 pandemic AC need be informed by real-world evidence.To examine whether lockdown measures are associated with consumption-related temporal psychological within-person mechanisms.This quantitative, intensive, longitudinal cohort study recruited 1743 participants from 3 sites February 20, 2020, 28, 2021. Data were provided before within second in Germany: (October...
Postoperative delirium (POD) is a serious complication following deep brain stimulation (DBS) but only received little attention. Its main risk factors are higher age and preoperative cognitive deficits. These also for long-term decline after DBS in Parkinson's disease (PD).
Introduction: Depressive symptoms are a frequent and distressing phenomenon in MS patients. Cross-sectional research links these to reduced brain gray matter volumes parts of the prefrontal temporal lobe as well subcortical structures like hippocampus, nucleus caudatus globus pallidus. Nevertheless, prospective relationships between regional volume course depressive poorly understood. Methods: Forty-four patients with relapsing–remitting or secondary progressive participated study two...
Theoretical accounts suggest that an alteration in the brain's learning mechanisms might lead to overhasty inferences, resulting psychotic symptoms. Here, we sought elucidate suggested link between maladaptive and psychosis. Ninety-eight healthy individuals with varying degrees of delusional ideation hallucinatory experiences performed a probabilistic reasoning task allowed us quantify inferences. Replicating previous results, found relationship inferences during reasoning. Computational...
<h3>Background:</h3> The maintenance of harmful alcohol use can be considered a reiterated decision in favour concrete drinking occasions. These decisions are often made despite an intention to quit or reduce consumption. We tested if hyperactive reward system and/or impaired cognitive control contribute such unfavourable decision-making. <h3>Methods:</h3> In this fMRI study, men with modest behaviour, which was measured using the Alcohol Use Disorders Identification Test (AUDIT), repeatedly...
This study aimed to investigate the development of opioid tolerance in patients receiving long-term methadone maintenance treatment (MMT).A region-wide cross-sectional was performed focusing on dosage and duration treatment. Differences between racemic levomethadone were examined. All 20 psychiatric hospitals all 110 outpatient clinics Berlin licensed offer MMT approached order reach under fulfilling DSM IV criteria opiate dependence. In study, 720 treated with or gave information Out these,...
Recent clinical studies have shown that agonists at muscarinic acetylcholine receptors effectively reduce schizophrenia symptoms. It is thus conceivable that, for the first time, a second substance class of procholinergic antipsychotics could become established alongside usual antidopaminergic antipsychotics. In addition, various basic science suggest there may be subgroup in which hypofunction etiological importance. This represent major opportunity individualized treatment if markers can...
2 Abstract In the search for neural correlates of consciousness, it has remained controversial whether prefrontal cortex determines what is consciously experienced or, alternatively, serves only complementary functions such as introspection or action. Here, we provide converging evidence from computational modeling and two functional magnetic resonance imaging experiments a key role inferior frontal in detecting perceptual conflicts that emerge ambiguous sensory information. Crucially,...
Abstract Background Sexual minorities such as lesbian, gay, and bisexual (LGB) people have an increased risk for suicide, whose reasons are not sufficiently understood. We aimed to test if differences in LGB acceptance explain variations general suicide rates on a country level. Methods used linear regression models the variation age-standardized 34 OECD countries based acceptance, which was recently assessed large international surveys polling population about their attitude towards...
Background Identifying predictors for treatment outcome in patients with posttraumatic stress disorder (PTSD) is important order to provide an effective treatment, but robust and replicated are not available up now.Objectives We investigated of a naturalistic sample PTSD admitted 8-week daycare cognitive behavioural therapy programme following wide range traumatic events.Method used machine learning (linear non-linear regressors cross-validation) predict at discharge 116 sustained effects 6...