A5068686115- Posttraumatic Stress Disorder Research
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Child and Adolescent Psychosocial and Emotional Development
- Eating Disorders and Behaviors
- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Treatment of Major Depression
- Sleep and Wakefulness Research
- Traumatic Brain Injury Research
- Resilience and Mental Health
- Substance Abuse Treatment and Outcomes
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Digital Mental Health Interventions
- Obsessive-Compulsive Spectrum Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Opioid Use Disorder Treatment
- Stress Responses and Cortisol
- Migration, Health and Trauma
- Child Abuse and Trauma
- Sleep and Work-Related Fatigue
- Nerve injury and regeneration
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
Charité - Universitätsmedizin Berlin
2013-2024
Humboldt-Universität zu Berlin
2023
Freie Universität Berlin
2023
St. Hedwig-Krankenhaus
2012-2023
Erasmus Hospital
2007
A diagnosis of schizophrenia is associated with a heterogeneous psychopathology including positive and negative symptoms. The disconnection hypothesis, an early pathophysiological framework conceptualizes the diversity symptoms as result disconnections in neural networks. In line this previous neuroimaging studies patients reported alterations within default mode network (DMN), most prominent at rest. aim present study was to investigate functional connectivity during rest healthy...
With the introduction of ICD-11 into clinical practice, reliable distinction between Posttraumatic Stress Disorder (PTSD) and Complex (CPTSD) becomes paramount. The semi-structured clinician-administered International Trauma Interview (ITI) aims to close this gap in research settings.
This study aimed to investigate the development of opioid tolerance in patients receiving long-term methadone maintenance treatment (MMT).A region-wide cross-sectional was performed focusing on dosage and duration treatment. Differences between racemic levomethadone were examined. All 20 psychiatric hospitals all 110 outpatient clinics Berlin licensed offer MMT approached order reach under fulfilling DSM IV criteria opiate dependence. In study, 720 treated with or gave information Out these,...
<b>Anliegen:</b> Systematische Erfassung der Dosierung sowie Nebenwirkungen Opiatsubstitution. <b>Methode:</b> Regionale Befragung von opiatabhängigen Patienten in Berlin. <b>Ergebnisse:</b> Levomethadon wurde signifikant höher dosiert als Methadon trotz adäquater Berücksichtigung Wirkstärken. 484 Teilnehmer gaben an, am häufigsten Sedierung und Schwitzen. Reizbarkeit/Nervosität gastrointestinale fanden sich häufiger unter Levomethadon. <b>Schlussfolgerung:</b> Die vorliegenden Ergebnisse...
Abstract Background Parents’ mental illness (MI) and parental history of early life maltreatment (ELM) are known to be significant risk factors for poor parenting while is a crucial mediator the intergenerational continuity child maltreatment. Hence, prevention programs families with an MI parent, which pay particular attention experiences ELM in urgently needed. Parental mentalizing was previously found mediate successful parenting. Interventions aimed at improving capacity reduced parents....
Objective Patients with posttraumatic stress disorder (PTSD) report changes in what they think of the world and themselves, referred to as cognitions, how think, reflected increased perseverative thinking. We investigated whether pre–post therapy two aspects thinking were associated symptom severity.
Abstract Background Distressing nightmares are a core symptom of posttraumatic stress disorder (PTSD) and contribute to psychiatric comorbidity, impaired physical health decreased social functioning. No specific pharmacological treatment for PTSD-related is yet approved. Preliminary clinical data indicate that cannabinoid agonists can improve overall PTSD symptoms in patients with PTSD. The primary objective the study examine efficacy oral dronabinol (BX-1) versus placebo reducing secondary...
Schizophrenia has been understood as a network disease with altered functional and structural connectivity in multiple brain networks compatible to the extremely broad spectrum of psychopathological, cognitive, behavioral symptoms this disorder. When building networks, are typically modeled independently: Functional models based on temporal correlations among regions, whereas anatomical characteristics. Combining both features may give rise more realistic reliable networks. In study, we...
Background Identifying predictors for treatment outcome in patients with posttraumatic stress disorder (PTSD) is important order to provide an effective treatment, but robust and replicated are not available up now.Objectives We investigated of a naturalistic sample PTSD admitted 8-week daycare cognitive behavioural therapy programme following wide range traumatic events.Method used machine learning (linear non-linear regressors cross-validation) predict at discharge 116 sustained effects 6...
Maternal early-life maltreatment (ELM) increases the risk of subsequent child maltreatment, but underlying mechanisms these intergenerational effects remain largely unknown. Identifying is crucial for developing preventive interventions that can break cycle abuse. Notably, previous research has shown ELM often results in attachment insecurity and altered anger characteristics. Therefore, this study determines whether characteristics mediate relationship between maternal history abuse...
Zusammenfassung. Hintergrund: Sexuelle Funktionsstörungen sind bei der Substitutionsbehandlung chronischen Opioidabhängigkeit häufig. Neben Methadon ist Levomethadon derzeit die in Deutschland am häufigsten eingesetzte Substanz zur Substitution. Bisher gibt es unserer Kenntnis nach keine Studie, sexuelle im Vergleich zu untersucht hat. Zielsetzung: Erfragung von sexuellen Funktionsstörungen. Material und Methoden: Wir führten eine Befragung männlichen opioidabhängigen Patienten unter mit...
Posttraumatic stress disorder (PTSD) is associated with psychosocial impairments, which represent a relevant focus for therapy. Previous results on the clinical predictors of these impairments were inconsistent. The data analyzed in contexts often suffer from high number correlated and small sample sizes, entailing risk model overfitting. In Bayesian regression, problem overfitting can be mitigated by usage specific zero-centered (regularizing) prior distributions. this study, we used 2 most...
Zusammenfassung Hintergrund Seit 2017 können in Deutschland Cannabisarzneimittel zu Lasten der Krankenkassen verordnet werden. Methode Ärztinnen und Ärzte waren zur Teilnahme an einer Begleiterhebung des Bundesinstituts für Arzneimittel Medizinprodukte (BfArM) verpflichtet. Diese Arbeit wertet 16 809 Datensätze aus, die zwischen dem 30.03.2017 31.12.2021 eingingen. Resultate Die erfasste 5582 Fälle mit psychiatrischer Diagnose. Über Hälfte Behandlungen erfolgte Dronabinol. 80% erfolgten...
Sleep disturbances are common in individuals with posttraumatic stress disorder. Exercise interventions a promising approach the treatment of sleep disorders, but little is known about efficacy exercise for associated A total 40 disorder were randomized to six sessions either high-intensity interval training or low-to-moderate-intensity training, administered within 12 days. quality was assessed over 24 days from baseline post Pittsburgh Quality Index, log, and waist-worn actigraphy....
Brain-derived neurotrophic factor (BDNF) is a protein important for synaptic plasticity and formation of memory. It suggested to play an role in the development psychiatric disorders like post-traumatic stress disorder (PTSD). Individuals with PTSD usually show decreased BDNF levels serum. Physical exercise has shown be effective increasing serum levels.