A5088810131- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Maternal Mental Health During Pregnancy and Postpartum
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Attachment and Relationship Dynamics
- Homicide, Infanticide, and Child Abuse
- Health, psychology, and well-being
- Family Support in Illness
- Infant Health and Development
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Intimate Partner and Family Violence
- Personality Disorders and Psychopathology
- Prenatal Substance Exposure Effects
- Psychotherapy Techniques and Applications
- Socioeconomic and Demographic Analysis
- Green IT and Sustainability
- Autism Spectrum Disorder Research
- Anesthesia and Neurotoxicity Research
- Gut microbiota and health
- Child and Animal Learning Development
- Kidney Stones and Urolithiasis Treatments
- Heavy Metal Exposure and Toxicity
- Data Visualization and Analytics
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2017-2025
Freie Universität Berlin
2017-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2017-2020
University of Applied Sciences Potsdam
2020
Universitätsklinikum Erlangen
2010
The association between maternal depression and adverse outcomes in children is well established. Similar links have been found for childhood abuse. One proposed pathway of risk transmission reduced emotional availability. Our aim was to investigate whether sensitive parenting impaired mothers with remission, among these abuse has an additional impact.The mother-child interaction 188 dyads assessed during a play situation using the Emotional Availability Scales, which measure overall...
Studies reporting accelerated ageing in children with affective disorders or maltreatment exposure have relied on algorithms for estimating epigenetic age derived from adult samples. These limited validity estimation during early development. We here use a pediatric buccal (PedBE) clock to predict DNA methylation-based deviation and without internalizing disorder assess the moderating effect of exposure. further conduct gene set enrichment analysis contribution glucocorticoid signaling PedBE...
Objective The immediate impact of child maltreatment on health and developmental trajectories over time is unknown. Longitudinal studies starting in the direct aftermath exposure with repeated follow‐up are needed. Method We assessed outcomes 6‐month intervals 2 years 173 children, aged 3–5 at study entry, including 86 children to emotional physical abuse or neglect within 6 months 87 nonmaltreated children. Assessments included clinician‐administered, self‐ parent‐report measures...
Abstract Background Maternal depression is associated with difficulties in understanding and adequately responding to children’s emotional signals. Consequently, the interaction between mother child often disturbed. However, little known about neural correlates of these parenting difficulties. Motivated by increasing evidence amygdala’s important role mediating maternal behavior, we investigated amygdala responses sad happy faces mothers remitted major disorder (rMDD) relative healthy...
In the original publication [...]
Childhood maltreatment (CM) is an established major risk factor for a number of negative health outcomes later in life. While epigenetic mechanisms, such as DNA methylation (DNAm), have been proposed means embedding this environmental factor, little known about its timing and trajectory, especially very young children. It also not clear whether additional adversities, often experienced by these children, converge on similar DNAm changes. Here, we calculated cumulative adversity score, which...
Background Early life maltreatment (ELM), borderline personality disorder (BPD) and major depressive (MDD) have been shown to increase the potential of abuse. Emotion regulation is an identified mediator for association ELM BPD with abuse potential. Until now, there has no study account co-occurrence these risk factors in one analysis, although MDD are known as common sequelae ELM. This paired a lack studies investigating effects on child well-being. Aims Our aims at (a) disentangling...
Abstract Exposure to child maltreatment increases the risk for psychiatric and physical diseases. Inflammation has been proposed as a mechanism through which early adverse experiences become biologically embedded. However, most studies providing evidence link between exposures inflammation have retrospective or cross-sectional in design, did not assess immediately after young children. In present study we investigated association childhood salivary C-reactive protein (CRP) concentrations...
Abstract Background Early life maltreatment (ELM), borderline personality disorder (BPD), and major depressive (MDD) have been associated with empathy deficits in different domains. Lack of maternal has also related to child behavioral problems. As ELM, BPD, MDD often co-occur, we aimed identify dissociable effects on due these three factors. In addition, investigate their indirect via psychopathology. Methods We included 251 mothers without (in remission), BPD ELM children, aged 5–12. used...
Abstract Background Parents’ mental illness (MI) and parental history of early life maltreatment (ELM) are known to be significant risk factors for poor parenting while is a crucial mediator the intergenerational continuity child maltreatment. Hence, prevention programs families with an MI parent, which pay particular attention experiences ELM in urgently needed. Parental mentalizing was previously found mediate successful parenting. Interventions aimed at improving capacity reduced parents....
Background: The brain and the intestinal microbiota are highly interconnected especially vulnerable to disruptions in early life. Emerging evidence indicates that psychosocial adversity detrimentally impacts microbiota, affecting both physical mental health. This study aims investigate gut microbiome young children immediate aftermath of maltreatment exposure. Methods: Maltreatment exposure was assessed 88 (ages 3–7) using Maternal Interview for Classification [MICM]. Children were allocated...
Abstract Creativity is a crucial factor in finding novel and useful visualization interaction techniques, but its emergence contingent on the right conditions. The focus of research has traditionally been to lesser degree process creating them with domain experts end users. This paper focuses collaborative design visualizations for information seeking knowledge management. difficult, yet common challenge any project find meaningful visual representations techniques carry out complex analysis...
Preschool mental disorders are often associated with significant interpersonal problems, related to impaired affect recognition, theory of mind (ToM), and empathy. To date, these skills have not been studied together in preschoolers externalizing behavior problems (EBPs). The aim the present study was investigate whether what extent preschool children EBPs show impairments ToM, Preschoolers EBPs, defined by current psychiatric treatment T-scores ≥ 60 on problem scale Child Behavior Checklist...
Maternal early-life maltreatment (ELM) increases the risk of subsequent child maltreatment, but underlying mechanisms these intergenerational effects remain largely unknown. Identifying is crucial for developing preventive interventions that can break cycle abuse. Notably, previous research has shown ELM often results in attachment insecurity and altered anger characteristics. Therefore, this study determines whether characteristics mediate relationship between maternal history abuse...