A5090949017- Child and Adolescent Psychosocial and Emotional Development
- Personality Disorders and Psychopathology
- Child Abuse and Trauma
- Maternal Mental Health During Pregnancy and Postpartum
- Psychosomatic Disorders and Their Treatments
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Suicide and Self-Harm Studies
- Psychotherapy Techniques and Applications
- Family Support in Illness
- Homicide, Infanticide, and Child Abuse
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Family Caregiving in Mental Illness
- Intimate Partner and Family Violence
- Evolutionary Psychology and Human Behavior
- Grief, Bereavement, and Mental Health
- Personality Traits and Psychology
- Attachment and Relationship Dynamics
- Infant Health and Development
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Adolescent Sexual and Reproductive Health
- Schizophrenia research and treatment
- Early Childhood Education and Development
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2024
Central Institute of Mental Health
2024
LMU Klinikum
2023
Ludwig-Maximilians-Universität München
2018-2023
German Center for Diabetes Research
2023
Chirurgische Universitätsklinik Heidelberg
2019
Charité - Universitätsmedizin Berlin
2018
<h3>Importance</h3> Although borderline personality disorder (BPD)—one of the most common, burdensome, and costly psychiatric conditions—is characterized by repeated interpersonal conflict instable relationships, neurobiological mechanism social interactive deficits remains poorly understood. <h3>Objective</h3> To apply recent advancements in investigation 2-person human interaction to investigate difficulties among people with BPD. <h3>Design, Setting, Participants</h3> Cross-brain...
Abstract Background Maternal depression is associated with difficulties in understanding and adequately responding to children’s emotional signals. Consequently, the interaction between mother child often disturbed. However, little known about neural correlates of these parenting difficulties. Motivated by increasing evidence amygdala’s important role mediating maternal behavior, we investigated amygdala responses sad happy faces mothers remitted major disorder (rMDD) relative healthy...
Borderline personality disorder (BPD) is characterized by altered perception of affective stimuli, including abnormal evaluation nociceptive input. However, whether or not perceptual alterations are present for its positive counterpart, i.e. pleasant touch (PT), has yet been examined. In the study, we applied standardized PT stimuli to hands 25 patients with BPD and healthy controls (HC) compared their perception. We used affect-modulated acoustic startle response as a physiological...
Abstract Background Previous eye-tracking studies provide preliminary evidence for a hypersensitivity to negative, potentially threatening interpersonal cues in borderline personality disorder (BPD). From an etiological point of view, such threat might be explained by biological vulnerability along with history early life adversities. The objective the current study was investigate and its association adverse childhood experiences (ACE) patients BPD employing technology. Methods We examined...
Aggression is highly prevalent in borderline personality disorder (BPD). Previous studies have identified specific biobehavioral mechanisms underlying aggression BPD, threat sensitivity being among them. We composited the mechanism-based anti-aggression psychotherapy (MAAP) order to target these mechanisms, and MAAP was found be superior non-specific supportive (NSSP) reducing aggressive behavior. In present study, we investigated whether brain expected involved were affected by MAAP. To...
Early-life maltreatment has severe consequences for the affected individual, and it an impact on next generation. To improve understanding of intergenerational effects abuse, we investigated early-life maternal sensitivity associated brain mechanisms during mother-child interactions.In total, 47 mothers (22 with a history physical and/or sexual childhood abuse 25 without, all without current mental disorders) took part in standardized real-life interaction their 7- to 11-year-old child (not...
Abstract Background Early life maltreatment (ELM), borderline personality disorder (BPD), and major depressive (MDD) have been associated with empathy deficits in different domains. Lack of maternal has also related to child behavioral problems. As ELM, BPD, MDD often co-occur, we aimed identify dissociable effects on due these three factors. In addition, investigate their indirect via psychopathology. Methods We included 251 mothers without (in remission), BPD ELM children, aged 5–12. used...
Summary Strengthening Attachment Competencies in Parents with Mental Illness: Adaptation and Pilot Testing of the Mentalization-Based Lighthouse Parenting Program Mentalizing describes imaginative ability to understand human behaviour terms mental states. illnesses experiences early maltreatment frequently show impairments mentalizing, which negatively impact their caregiving competences for child. A number mentalization-based programs strengthen parental have been developed most them...
Background Aggressive behaviour is a prevalent and harmful phenomenon in patients with borderline personality disorder (BPD). However, no short-term, low-cost programme exists that specifically focuses on aggression. Aims Attuning therapy modules to pathogenetic mechanisms underlie reactive aggression BPD, we composed 6 week mechanism-based anti-aggression psychotherapy (MAAP) approach for the group setting, which tested against non-specific supportive (NSSP). Method A cluster-randomised...
Abstract Background Parents’ mental illness (MI) and parental history of early life maltreatment (ELM) are known to be significant risk factors for poor parenting while is a crucial mediator the intergenerational continuity child maltreatment. Hence, prevention programs families with an MI parent, which pay particular attention experiences ELM in urgently needed. Parental mentalizing was previously found mediate successful parenting. Interventions aimed at improving capacity reduced parents....
<b><i>Introduction:</i></b> Early-life maltreatment (ELM) has long-lasting negative consequences and is the most important general risk factor for mental disorders. Nevertheless, a number of maltreated children grow up to become healthy adults have therefore been called ‘resilient'. The aim current study investigate ‘resilience factors' in context severe ELM. <b><i>Method:</i></b> was part large multicenter project Understanding Breaking...
Auditory verbal hallucinations (AVH) are transdiagnostic phenomena that can occur in several mental disorders, including borderline personality disorder (BPD). Despite the relevance of these symptoms, very little is known about neural signatures AVH BPD.We used structural magnetic resonance imaging to investigate multiple markers brain morphology BPD patients presenting with a lifetime history (AVH, n = 6) versus without (nAVH, 10) and healthy controls (HC, 12). The Computational Anatomy...