A5018278462- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Action Observation and Synchronization
- Personality Disorders and Psychopathology
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Embodied and Extended Cognition
- Schizophrenia research and treatment
- Evolutionary Psychology and Human Behavior
- Cardiac Health and Mental Health
- Genetic Associations and Epidemiology
- Psychological Well-being and Life Satisfaction
- Behavioral Health and Interventions
- Nerve injury and regeneration
- Child and Animal Learning Development
- Urban Green Space and Health
Heidelberg University
2013-2024
University Hospital Heidelberg
2011-2024
Central Institute of Mental Health
2013-2024
Wellcome Centre for Human Neuroimaging
2020-2024
University College London
2020-2024
Medizinische Fakultät Mannheim
2023
National Hospital for Neurology and Neurosurgery
2020-2022
Significance Converging evidence points to a role for glutamate and altered brain network dynamics in schizophrenia, but the molecular genetic contributions are poorly understood. Here, we applied dynamic neuroscience methods neuroimaging working memory data identify potential alterations flexibility related schizophrenia risk N -methyl- d -aspartate (NMDA) receptor hypofunction. Consistent with dynamics, detected significant increases patients healthy first-degree relatives, subjects...
Significance Social interaction is the likely driver of human brain evolution, critical for health, and underlies phenomena as varied childhood development, stock market behavior, much what studied in humanities. However, appropriate experimental methods to study underlying processes are still developing technically challenging. Here, we extend previous pioneering approaches neuroimaging [functional MRI (fMRI) hyperscanning] provide a method studying information flow between interacting...
Neural plasticity is crucial for understanding the experience-dependent reorganization of brain regulatory circuits and pathophysiology schizophrenia. An important circuit-level feature derived from functional magnetic resonance imaging (fMRI) prefrontal-hippocampal seeded connectivity during working memory, best established intermediate phenotype schizophrenia risk to date. The a promising marker effects plasticity-enhancing interventions, such as high-frequency repetitive transcranial...
<h3>Importance</h3> Although borderline personality disorder (BPD)—one of the most common, burdensome, and costly psychiatric conditions—is characterized by repeated interpersonal conflict instable relationships, neurobiological mechanism social interactive deficits remains poorly understood. <h3>Objective</h3> To apply recent advancements in investigation 2-person human interaction to investigate difficulties among people with BPD. <h3>Design, Setting, Participants</h3> Cross-brain...
Advances in social neuroscience have made neural signatures of exchange measurable simultaneously across people. This has identified brain regions differentially active during interaction between human dyads, but the underlying systems-level mechanisms are incompletely understood. paper introduces dynamic causal modeling and Bayesian model comparison to assess directed connectivity two brains context hyperscanning (h-DCM). In this setting, correlated neuronal responses become data features...
Cognitive-behavioral therapy (CBT) leverages interactions between thoughts, feelings, and behaviors. To deepen understanding of these interactions, we present a computational (active inference) model CBT that allows formal simulations cognitive interventions (i.e., restructuring) behavioral exposure) in producing adaptive behavior change reducing maladaptive avoidance behavior). Using spider phobia as concrete example more generally, show indicating when conscious beliefs about safety/danger...
Abstract Previous research suggests a role of the dorsomedial prefrontal cortex (dmPFC) in metacognitive representation social information, while right posterior superior temporal sulcus (pSTS) has been linked to perception. This study targeted these functional roles context spontaneous mentalizing. An animated shapes task was presented 46 subjects during magnetic resonance imaging. Stimuli consisted video clips depicting whose movement patterns prompt mentalizing or simple intention...
People often form polarized beliefs, imbuing objects (e.g., themselves or others) with unambiguously positive negative qualities. In clinical settings, this is referred to as dichotomous thinking "splitting" and a feature of several psychiatric disorders. Here, we introduce Bayesian model splitting that parameterizes tendency rigidly categorize either entirely "Bad" "Good," rather than flexibly learn dispositions along continuous scale. Distinct from the previous descriptive theories, makes...
The debilitating effects of social dysfunction in many psychiatric disorders prompt the need for systems-level biomarkers abilities that can be applied clinical populations and longitudinal studies. A promising neuroimaging approach is animated shapes paradigm based on so-called Frith-Happé animations (FHAs) which trigger spontaneous mentalizing with minimal cognitive demands. Here, we presented FHAs during functional magnetic resonance imaging to 46 subjects examined specificity sensitivity...
Abstract In traditional game theory tasks, social decision‐making is centered on the prediction of intentions (i.e., mentalizing) strangers or manipulated responses. contrast, real‐life scenarios often involve familiar individuals in dynamic environments. Further research needed to explore neural correlates with changes available information and environmental settings. This study collected fMRI hyperscanning data ( N = 100, 46 same‐sex pairs were analyzed) investigate sibling engaging an...
Abstract Love is probably the most fascinating feeling that a person ever experiences. However, little known about what happening in brains of romantic couple—the central and salient relationship during adult age—while they are particularly tender exchanging loving words with one another. To gain insight into nearly natural couple interaction, we collected data from N = 84 individuals (including 43 heterosexual couples) simultaneously two functional magnetic resonance imaging scanners, while...
Exaggerated reactivity to acute psychosocial stress is associated with an increased risk of cardiovascular and metabolic disease. A dysfunction the cortico-limbic network coordinating peripheral adaptation exposure may constitute a brain mechanism underlying this association. We opted characterize changes in individuals low high cardiometabolic (CMR). In 57 subjects without overt cardiac or cerebral disease, Framingham score presence/absence type 2 diabetes syndrome defined CMR. Psychosocial...
Abstract Functional neuroimaging of social stress induction has considerably furthered our understanding the neural risk architecture stress‐related mental disorders. However, broad application existing paradigms is challenging, among others due to relatively high intensity employed stressors, which limits applications in patients and longitudinal study designs. Here, we introduce a less intense paradigm subjects anticipate, prepare, give speeches under simulated evaluation without harsh...
People often form polarized beliefs about others. In a clinical setting this is referred to as dichotomous or ‘split’ representation of others, whereby others are not imbued with possessing mixtures opposing properties. Here, we formalise these accounts an oversimplified categorical model others’ internal, intentional, states. We show how resulting idealization and devaluation can be stabilized by attributing unexpected behaviour fictive external factors. For example, under idealization,...
Cognitive-behavioral therapy (CBT) leverages interactions between thoughts, feelings, and actions. In this paper, we use neurocomputational modelling to deepen our understanding of the mechanisms underlying these how therapeutic interventions can produce behavioral change through different in cases. We describe an active inference model that allows formal simulations cognitive (i.e., restructuring) exposure) producing adaptive behavior reducing maladaptive avoidance behavior). Using example...
Abstract Love is probably the most fascinating feeling that a person ever experiences. However, little known about what happening in brains of romantic couple –the central and salient relationship during adult age– while they are particularly tender exchanging loving words with one another. To gain insight into nearly natural interaction, we collected data from N=84 individuals (including N=43 heterosexual couples) simultaneously two functional magnetic resonance imaging scanners, sent...