Stephan Ripke
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Genomic variations and chromosomal abnormalities
- Autism Spectrum Disorder Research
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Child and Adolescent Psychosocial and Emotional Development
- Cognitive Abilities and Testing
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Genetic Syndromes and Imprinting
- Birth, Development, and Health
- Genetic Mapping and Diversity in Plants and Animals
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Inflammatory Bowel Disease
- Neural and Behavioral Psychology Studies
- Genetic and phenotypic traits in livestock
- Stress Responses and Cortisol
- Diet and metabolism studies
- Adolescent and Pediatric Healthcare
- Mental Health Research Topics
Charité - Universitätsmedizin Berlin
2016-2025
Broad Institute
2016-2025
Freie Universität Berlin
2019-2025
Humboldt-Universität zu Berlin
2019-2025
Massachusetts General Hospital
2015-2024
Central Institute of Mental Health
2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Harvard University
2013-2023
University of Utah
2023
Abstract Here we describe an R library for genome-wide association (GWA) analysis. It implements effective storage and handling of GWA data, fast procedures genetic data quality control, testing single nucleotide polymorphisms with binary or quantitative traits, visualization results also provides easy interfaces to standard statistical graphical implemented in base special libraries We evaluated GenABEL using one simulated two real sets. conclude that enables the analysis on desktop...
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified genetic sharing 25 disorders from genome-wide association studies 265,218 patients 784,643 control participants assessed relationship to 17 phenotypes 1,191,588 individuals. Psychiatric common variant risk, whereas neurological appear more distinct one another psychiatric disorders. also identified significant between a number...
Getting HIV Under Control Approximately 1 in 300 people infected with are “controllers” who able to maintain long-term control of the virus without medication and do not progress AIDS. Uncovering genetic basis for this ability is great interest. Pereyra et al. (p. 1551 , published online 4 November; see Perspective by McMichael Jones ) now present genome-wide association results from patients enrolled International Controllers Study. The analysis compared controllers European,...
Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...