Stephan Ripke

ORCID: 0000-0003-3622-835X
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About
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Research Areas
  • Genetic Associations and Epidemiology
  • Genetics and Neurodevelopmental Disorders
  • Bipolar Disorder and Treatment
  • Genomic variations and chromosomal abnormalities
  • Autism Spectrum Disorder Research
  • Genomics and Rare Diseases
  • Epigenetics and DNA Methylation
  • Bioinformatics and Genomic Networks
  • Child and Adolescent Psychosocial and Emotional Development
  • Cognitive Abilities and Testing
  • Schizophrenia research and treatment
  • Tryptophan and brain disorders
  • Genetic Syndromes and Imprinting
  • Birth, Development, and Health
  • Genetic Mapping and Diversity in Plants and Animals
  • Functional Brain Connectivity Studies
  • Attention Deficit Hyperactivity Disorder
  • Health, Environment, Cognitive Aging
  • Inflammatory Bowel Disease
  • Neural and Behavioral Psychology Studies
  • Genetic and phenotypic traits in livestock
  • Stress Responses and Cortisol
  • Diet and metabolism studies
  • Adolescent and Pediatric Healthcare
  • Mental Health Research Topics

Charité - Universitätsmedizin Berlin
2016-2025

Broad Institute
2016-2025

Freie Universität Berlin
2019-2025

Humboldt-Universität zu Berlin
2019-2025

Massachusetts General Hospital
2015-2024

Central Institute of Mental Health
2024

Heidelberg University
2024

University Hospital Heidelberg
2024

Harvard University
2013-2023

University of Utah
2023

Stephan Ripke Benjamin M. Neale Aiden Corvin James Walters Kai-How Farh and 95 more Peter Holmans Phil Lee Brendan Bulik‐Sullivan David Collier Hailiang Huang Tune H. Pers Ingrid Agartz Esben Agerbo Margot Albus Madeline Alexander Farooq Amin Silviu‐Alin Bacanu Martin Begemann Richard A. Belliveau Judit Bene Sarah E. Bergen Elizabeth Bevilacqua Tim B. Bigdeli Donald W. Black Richard Bruggeman Nancy G. Buccola Randy L. Buckner William Byerley Wiepke Cahn Guiqing Cai Dominique Campion Rita M. Cantor Vaughan J. Carr Noa Carrera Stanley V. Catts Kimberly D. Chambert Raymond Chan Ronald Y.L. Chen Eric Chen Wei Cheng Eric Cheung Siow Ann Chong C. Robert Cloninger David Cohen Nadine Cohen Paul Cormican Nick Craddock James J. Crowley David Curtis Michael Davidson Kenneth L. Davis Franziska Degenhardt Jurgen Del‐Favero Ditte Demontis Dimitris Dikeos Timothy G. Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Naser Durmishi Peter Eichhammer Johan G. Eriksson Valentina Escott‐Price Laurent Essioux Ayman H. Fanous Martilias S. Farrell Josef Frank Lude Franke Robert Freedman Nelson B. Freimer Marion Friedl Joseph I. Friedman Menachem Fromer Giulio Genovese Lyudmila Georgieva Ina Giegling Paola Giusti‐Rodríguez Stephanie Godard Jacqueline I. Goldstein В. Е. Голимбет Srihari Gopal Jacob Gratten Lieuwe de Haan Christian Hammer Marian L. Hamshere Mark Hansen Thomas Hansen Vahram Haroutunian Annette M. Hartmann Frans Henskens Stefan Herms Joel N. Hirschhorn Per Hoffmann Andrea Hofman Mads V. Hollegaard David M. Hougaard Masashi Ikeda Inge Joa

10.1038/nature13595 article EN Nature 2014-07-01
Sang Lee Stephan Ripke Benjamin M. Neale Stephen V. Faraone Shaun Purcell and 95 more Roy H. Perlis Bryan Mowry Anita Thapar Michael E. Goddard Esther M. John Devin Absher Ingrid Agartz Huda Akil Farooq Amin Ole A. Andreassen Adebayo Anjorin Richard Anney Verneri Anttila Dan E. Arking Philip Asherson Maria Helena Pinto de Azevedo Lena Backlund Judith A. Badner Anthony Bailey Tobias Banaschewski Jack D. Barchas Michael R. Barnes Thomas B. Barrett Nicholas Bass Agatino Battaglia Michael J. Bauer Mónica Bayés Frank Bellivier Sarah E. Bergen Wade H. Berrettini Catalina Betancur Thomas Bettecken Joseph Biederman Elisabeth B. Binder Donald W. Black Douglas Blackwood Cinnamon S. Bloss Michael Boehnke Dorret I. Boomsma Gerome Breen René Breuer Richard Bruggeman Paul Cormican Nancy G. Buccola Jan K. Buitelaar William E. Bunney Joseph D. Buxbaum William Byerley Enda M. Byrne Sian Caesar Wiepke Cahn Rita M. Cantor Miguel Casas Aravinda Chakravarti Kimberly Chambert Khalid Choudhury Sven Cichon C. Robert Cloninger David Collier Edwin H. Cook Hilary Coon Bru Cormand Aiden Corvin William Coryell David W. Craig Ian Craig Jennifer Crosbie Michael L. Cuccaro David Curtis Darina Czamara Susmita Datta Géraldine Dawson Richard Day Eco J. C. de Geus Franziska Degenhardt Srdjan Djurovic Gary Donohoe Alysa E. Doyle Jubao Duan Frank Dudbridge Eftichia Duketis Richard P. Ebstein Howard J. Edenberg Josephine Elia Sean Ennis Bruno Étain Ayman H. Fanous Anne Farmer I. Nicol Ferrier Matthew Flickinger Éric Fombonne Tatiana Foroud Josef Frank Barbara Franke Christine Fraser

10.1038/ng.2711 article EN Nature Genetics 2013-08-11

Abstract Here we describe an R library for genome-wide association (GWA) analysis. It implements effective storage and handling of GWA data, fast procedures genetic data quality control, testing single nucleotide polymorphisms with binary or quantitative traits, visualization results also provides easy interfaces to standard statistical graphical implemented in base special libraries We evaluated GenABEL using one simulated two real sets. conclude that enables the analysis on desktop...

10.1093/bioinformatics/btm108 article EN Bioinformatics 2007-03-23
Verneri Anttila Brendan Bulik‐Sullivan Hilary K. Finucane Raymond K. Walters José Brás and 95 more Laramie E. Duncan Valentina Escott‐Price Guido J. Falcone Padhraig Gormley Rainer Malik Nikolaos A. Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H. Lee Patrick Turley Benjamin Grenier‐Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean‐François Deleuze Emmanuelle Duron Badri N. Vardarajan Christiane Reitz Alison Goate Matthew J. Huentelman M. Ilyas Kamboh Eric B. Larson Ekaterina Rogaeva Peter St George‐Hyslop Hákon Hákonarson Walter A. Kukull Lindsay A. Farrer Lisa L. Barnes Thomas G. Beach F. Yesim Demirci Elizabeth Head Christine M. Hulette Gregory A. Jicha John S.K. Kauwe Jonathan Kaye James B. Leverenz Allan I. Levey Andrew P. Lieberman V. Shane Pankratz Wayne W. Poon Joseph F. Quinn Andrew J. Saykin Lon S. Schneider Amanda Smith Joshua A. Sonnen Robert A. Stern Vivianna M. Van Deerlin Linda J. Van Eldik Denise Harold Giancarlo Russo David C. Rubinsztein Antony Bayer Magda Tsolaki Petroula Proitsi Nick C. Fox Harald Hampel Michael J. Owen Simon Mead Peter Passmore Kevin Morgan Markus M. Nöthen Jonathan M. Schott Martin N. Rossor Michelle K. Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al‐Chalabi Joshua C. Bis Agustı́n Ruiz Merçé Boada Sudha Seshadri Alexa S. Beiser Kenneth Rice Sven J. van der Lee Philip L. De Jager Daniel H. Geschwind Markus J. Riemenschneider Steffi G. Riedel‐Heller Jerome I. Rotter Gerhard Ransmayr Bradley T. Hyman Carlos Cruchaga Montserrat Alegret Bendik S. Winsvold Priit Palta Kai-How Farh Ester Cuenca-León Nicholas A. Furlotte

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified genetic sharing 25 disorders from genome-wide association studies 265,218 patients 784,643 control participants assessed relationship to 17 phenotypes 1,191,588 individuals. Psychiatric common variant risk, whereas neurological appear more distinct one another psychiatric disorders. also identified significant between a number...

10.1126/science.aap8757 article EN Science 2018-06-21
Pamela Sklar Stephan Ripke Laura J. Scott Ole A. Andreassen Sven Cichon and 95 more Nick Craddock Howard J. Edenberg John I. Nürnberger Marcella Rietschel Douglas Blackwood Aiden Corvin Matthew Flickinger Weihua Guan Morten Mattingsdal Andrew McQuillin Phoenix Kwan Thomas F. Wienker Mark J. Daly Frank Dudbridge Peter Holmans Danyu Lin Margit Burmeister Tiffany A. Greenwood Marian L. Hamshere Pierandrea Muglia Erin N. Smith Peter P. Zandi Caroline M. Nievergelt R. Anne McKinney Paul D. Shilling Nicholas J. Schork Cinnamon S. Bloss Tatiana Foroud Daniel L. Koller Elliot S. Gershon Chunyu Liu Judith A. Badner William A. Scheftner William Lawson Evaristus A. Nwulia Maria Hipolito William Coryell John Rice William Byerley Francis J. McMahon Thomas G. Schulze Wade H. Berrettini Falk W. Lohoff James B. Potash Pamela B. Mahon Melvin G. McInnis Sebastian Zöllner Peng Zhang David W. Craig Szabocls Szelinger Thomas B. Barrett René Breuer Sandra Meier Jana Strohmaier Stephanie H. Witt Federica Tozzi Anne Farmer Peter McGuffin John S. Strauss Wei Xu Kristen M. Kennedy John B. Vincent K. Matthews Richard Day Manuel A. R. Ferreira Colm Ó'Dúshláine Roy H. Perlis Soumya Raychaudhuri Douglas M. Ruderfer Susan J. Lee Jordan W. Smoller Jun Li Devin Absher William E. Bunney Jack D. Barchas Alan F. Schatzberg Edward G. Jones Fan Meng Robert C. Thompson Stanley J. Watson Richard M. Myers Huda Akil Michael Boehnke Kim Chambert Jennifer L. Moran Ed Scolnick Srdjan Djurovic Ingrid Melle Gunnar Morken Michael Gill Derek W. Morris Emma M. Quinn Thomas W. Mühleisen Franziska Degenhardt Manuel Mattheisen

10.1038/ng.943 article EN Nature Genetics 2011-09-18
Bjarni J. Vilhjálmsson Jian Yang Hilary K. Finucane Alexander Gusev Sara Lindström and 95 more Stephan Ripke Giulio Genovese Po−Ru Loh Gaurav Bhatia Ron Do Tristan J. Hayeck Hong‐Hee Won Sekar Kathiresan Michele T. Pato Carlos N. Pato Rulla M. Tamimi Eli A. Stahl Noah Zaitlen Bogdan Paşaniuc Gillian M. Belbin Eimear E. Kenny Mikkel Heide Schierup Philip L. De Jager Nikolaos A. Patsopoulos Steve McCarroll Mark J. Daly Shaun Purcell Daniel I. Chasman Benjamin M. Neale Michael E. Goddard Peter M. Visscher Peter Kraft Hon‐Cheong So Alkes L. Price Stephan Ripke Benjamin M. Neale Aiden Corvin James Walters Kai-How Farh Peter Holmans Phil Lee Brendan Bulik‐Sullivan David Collier Hailiang Huang Tune H. Pers Ingrid Agartz Esben Agerbo Margot Albus Madeline Alexander Farooq Amin Silviu‐Alin Bacanu Martin Begemann Richard A. Belliveau Judit Bene Sarah E. Bergen Elizabeth Bevilacqua Tim B. Bigdeli Donald W. Black Richard Bruggeman Nancy G. Buccola Randy L. Buckner William Byerley Wiepke Cahn Guiqing Cai Dominique Campion Rita M. Cantor Vaughan J. Carr Noa Carrera Stanley V. Catts Kimberly D. Chambert Raymond Chan Ronald Y.L. Chen Eric Chen Wei Cheng Eric F.C. Cheung Siow Ann Chong C. Robert Cloninger David Cohen Nadine Cohen Paul Cormican Nick Craddock James J. Crowley David Curtis Michael Davidson Kenneth L. Davis Franziska Degenhardt Jurgen Del‐Favero Lynn E. DeLisi Ditte Demontis Dimitris Dikeos Timothy G. Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Naser Durmishi Peter Eichhammer Johan G. Eriksson Valentina Escott‐Price

10.1016/j.ajhg.2015.09.001 article EN publisher-specific-oa The American Journal of Human Genetics 2015-10-01
Florencia Pereyra Xiaoming Jia Paul J. McLaren Amalio Telenti Paul I. W. de Bakker and 95 more Bruce D. Walker Stephan Ripke Chanson J. Brumme Sara L. Pulit Mary Carrington Carl Kadie Jonathan M. Carlson David Heckerman Robert Graham Robert M. Plenge Steven G. Deeks Lauren Gianniny Gabriel Crawford Jordan Sullivan Elena González Leela Davies Amy L. Camargo Jamie Moore Nicole Beattie Supriya Gupta Andrew Crenshaw Noël P. Burtt Candace Guiducci Namrata Gupta Xiaojiang Gao Qi Ying Yuko Yuki Alicja Piechocka‐Trocha Emily Cutrell Rachel Rosenberg Kristin Moss Paul Lemay Jessica O'Leary Todd M. Schaefer Pranshu Verma Ildikó Tóth Brian L. Block B.M. Baker Alissa C. Rothchild Jeffrey Lian Jacqueline Proudfoot Donna Marie L. Alvino Seanna Vine Marylyn M. Addo Todd M. Allen Marcus Altfeld Matthew R. Henn Sylvie Le Gall Hendrik Streeck David W. Haas Daniel R. Kuritzkes Gregory K. Robbins Robert W. Shafer Roy M. Gulick Cecilia Shikuma Richard Haubrich Sharon A. Riddler Paul E. Sax Eric S. Daar Heather J. Ribaudo Brian K. Agan Shanu Agarwal Richard L Ahern Brady Allen Sherly Altidor Eric Lewin Altschuler Sujata Ambardar Kathryn Anastos Ben Anderson Val Anderson Ushan Andrady Diana Antoniskis David R. Bangsberg D Barbaro W W Barrie Jennifer Bartczak Simon Barton Patricia Basden Nesli Basgoz Suzane Bazner Nicholaos Bellos Anne M Benson Judith Berger Nicole F. Bernard Annette M Bernard Christopher Birch Stanley Bodner Robert Bolan Emilie T Boudreaux Meg Bradley J. Braun Jon E Brndjar Stephen J. Brown Katherine A. Brown Sheldon T. Brown

Getting HIV Under Control Approximately 1 in 300 people infected with are “controllers” who able to maintain long-term control of the virus without medication and do not progress AIDS. Uncovering genetic basis for this ability is great interest. Pereyra et al. (p. 1551 , published online 4 November; see Perspective by McMichael Jones ) now present genome-wide association results from patients enrolled International Controllers Study. The analysis compared controllers European,...

10.1126/science.1195271 article EN Science 2010-11-05
Christian R. Marshall Daniel P. Howrigan Daniele Merico Bhooma Thiruvahindrapuram Wenting Wu and 95 more Douglas S. Greer Danny Antaki Aniket Shetty Peter Holmans Dalila Pinto Madhusudan Gujral William M. Brandler Dheeraj Malhotra Zhouzhi Wang Karin V. Fuentes Fajarado Michelle S. Maile Stephan Ripke Ingrid Agartz Margot Albus Madeline Alexander Farooq Amin Joshua R. Atkins Silviu‐Alin Bacanu Richard A. Belliveau Sarah E. Bergen Marcelo Bertalan Elizabeth Bevilacqua Tim B. Bigdeli Donald W. Black Richard Bruggeman Nancy G. Buccola Randy L. Buckner Brendan Bulik‐Sullivan William Byerley Wiepke Cahn Guiqing Cai Murray J. Cairns Dominique Campion Rita M. Cantor Vaughan J. Carr Noa Carrera Stanley V. Catts Kimberley D. Chambert Wei Cheng C. Robert Cloninger David Cohen Paul Cormican Nick Craddock Benedicto Crespo‐Facorro James J. Crowley David Curtis Michael Davidson Kenneth L. Davis Franziska Degenhardt Jurgen Del‐Favero Lynn E. DeLisi Dimitris Dikeos Timothy G. Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Peter Eichhammer Johan G. Eriksson Valentina Escott‐Price Laurent Essioux Ayman H. Fanous Kai-How Farh Martilias S. Farrell Josef Frank Lude Franke Robert Freedman Nelson B. Freimer Joseph I. Friedman Andreas J. Forstner Menachem Fromer Giulio Genovese Lyudmila Georgieva Elliot S. Gershon Ina Giegling Paola Giusti‐Rodríguez Stephanie Godard Jacqueline I. Goldstein Jacob Gratten Lieuwe de Haan Marian L. Hamshere Thomas Hansen Thomas Hansen Vahram Haroutunian Annette M. Hartmann Frans A. Henskens Stefan Herms Joel N. Hirschhorn Per Hoffmann Andrea Hofman Hailiang Huang Masashi Ikeda Inge Joa Anna K. Kähler

10.1038/ng.3725 article EN Nature Genetics 2016-11-21

Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...

10.1126/science.aad6469 article EN Science 2018-02-09
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