A5066628402- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical and Molecular Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Tuberculosis Research and Epidemiology
- HIV-related health complications and treatments
- Mycobacterium research and diagnosis
- SARS-CoV-2 detection and testing
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Tuberculosis
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- COVID-19 and Mental Health
- Computational Drug Discovery Methods
- Topic Modeling
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
Stanford University
2016-2025
Stanford Medicine
2004-2025
Palo Alto University
2000-2024
National Institutes of Health
2016
University of New Mexico
2011
Gilead Sciences (United States)
2000-2010
KU Leuven
2003-2010
Hesco (United States)
2010
Environmental Protection Agency
2009
University College London
2006-2009
Getting HIV Under Control Approximately 1 in 300 people infected with are “controllers” who able to maintain long-term control of the virus without medication and do not progress AIDS. Uncovering genetic basis for this ability is great interest. Pereyra et al. (p. 1551 , published online 4 November; see Perspective by McMichael Jones ) now present genome-wide association results from patients enrolled International Controllers Study. The analysis compared controllers European,...
The HIV RT and Protease Sequence Database is an on-line relational database that catalogues evolutionary drug-related human immunodeficiency virus reverse transcriptase (RT) protease sequence variation (http://hivdb.stanford.edu). contains a compilation of nearly all published sequences including International Collaboration submissions (e.g., GenBank) in journal articles. Sequences are linked to data about the source sample anti-HIV drug treatment history individual from whom isolate was...
Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines provide feedback on the success prevention programs. To accurately compare rates across geographic regions times, World Health Organization has recommended adoption a consensus genotypic definition resistance. In January 2007, we outlined criteria for developing list mutations drug-resistance surveillance compiled 80 RT protease meeting these (surveillance mutations;...
Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance tests is one most difficult tasks facing clinicians caring for HIV-1-infected patients. There are many mutations, and they arise in complex patterns that cause varying levels drug resistance. In addition, HIV-1 exists vivo as a population containing genomic variants. Genotypic-resistance testing detects mutations present common variants but may not detect minor Therefore, interpretation...
In the United States there have been recent outbreaks of multidrug-resistant tuberculosis. These primarily involved persons infected with human immunodeficiency virus (HIV).
The detection of mutant spectra within a population microorganisms is critical for the management drug-resistant infections. We performed ultra-deep pyrosequencing to detect minor sequence variants in HIV-1 protease and reverse transcriptase (RT) genes from clinical plasma samples. estimated empirical error rates four plasmid clones used them develop statistical approach distinguish authentic sequencing errors eight Ultra-deep detected an average 58 per sample compared with by conventional...
<h2>Summary</h2><h3>Background</h3> Antiretroviral therapy (ART) is crucial for controlling HIV-1 infection through wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir disoproxil fumarate-containing regimens are increasingly used to treat prevent HIV, although few data exist frequency risk factors of acquired drug resistance in regions hardest hit by the HIV pandemic. We aimed do a global assessment after virological failure with first-line...
Contemporary antiretroviral therapies (ART) and management strategies have diminished both human immunodeficiency virus (HIV) treatment failure the acquired resistance to drugs in resource-rich regions, but transmission of drug-resistant viruses has not similarly decreased. In low- middle-income ART roll-out improved outcomes, resulted increasing transmitted resistances. Our objective was review methods detect it, provide updated recommendations for testing monitoring drug HIV-infected...
Abstract There are many pharmacologic therapies that being used or considered for treatment of coronavirus disease 2019 (COVID-19), with rapidly changing efficacy and safety evidence from trials. The objective was to develop evidence-based, rapid, living guidelines intended support patients, clinicians, other healthcare professionals in their decisions about management patients COVID-19. In March 2020, the Infectious Diseases Society America (IDSA) formed a multidisciplinary guideline panel...
Among the 30 nonsynonymous nucleotide substitutions in Omicron S-gene are 13 that have only rarely been seen other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of at sites will likely impact (1) interactions between subunits Spike trimer and predisposition to shift from down up configurations, (2) with ACE2 receptors, (3) priming for membrane fusion. We show here that, based on both rarity these intrapatient sequencing reads patterns selection...
As novel SARS-CoV-2 variants with different patterns of spike protein mutations have emerged, the susceptibility these to neutralization by antibodies has been rapidly assessed. However, data are generated using approaches and scattered across publications making it difficult for be located synthesized. The Stanford Coronavirus Resistance Database (CoV-RDB; https://covdb.stanford.edu ) is designed house comprehensively curated published on neutralizing monoclonal (mAbs), convalescent plasma...
Background The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation 470 million worldwide COVID-19 infections, corresponds around 200 people experiencing long COVID symptoms. Despite this, its clinical features are not well-defined. Methods We collected retrospective data from 140 patients with a post-COVID-19 clinic demographics, risk factors, illness severity (graded as one-mild five-severe), functional status, 29 symptoms principal component cluster...
Importance There is an urgent need to identify treatments for postacute sequelae of SARS-CoV-2 infection (PASC). Objective To assess the efficacy a 15-day course nirmatrelvir-ritonavir in reducing severity select PASC symptoms. Design, Setting, and Participants This was 15-week blinded, placebo-controlled, randomized clinical trial conducted from November 2022 September 2023 at Stanford University (California). The participants were adults with moderate severe symptoms 3 months or longer...
The optimal sequencing of antiretroviral regimens for the treatment infection with human immunodeficiency virus type 1 (HIV-1) is unknown. We compared several different strategies.This multicenter, randomized, partially double-blind trial used a factorial design to compare pairs sequential three-drug regimens, starting regimen including zidovudine and lamivudine or didanosine stavudine in combination either nelfinavir efavirenz. primary end point was length time failure second regimen.A...