A5033772317- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Drug-Induced Adverse Reactions
- Pharmaceutical Practices and Patient Outcomes
- Clostridium difficile and Clostridium perfringens research
- Blood disorders and treatments
- Microscopic Colitis
- Urinary Tract Infections Management
- Infective Endocarditis Diagnosis and Management
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Nosocomial Infections in ICU
- COVID-19 diagnosis using AI
- Sepsis Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Innovations in Medical Education
- Artificial Intelligence in Healthcare and Education
- Vibrio bacteria research studies
- Patient Satisfaction in Healthcare
Temple University
2016-2025
Infectious Diseases Society of America
2021
Gallagher (United States)
2000-2016
Merck (Singapore)
2016
Engineering Associates (United States)
2016
Temple University Hospital
2011-2013
American College of Clinical Pharmacy
2010-2013
Office of Infectious Diseases
2013
Temple College
2012
Crozer-Keystone Health System
2012
Abstract There are many pharmacologic therapies that being used or considered for treatment of coronavirus disease 2019 (COVID-19), with rapidly changing efficacy and safety evidence from trials. The objective was to develop evidence-based, rapid, living guidelines intended support patients, clinicians, other healthcare professionals in their decisions about management patients COVID-19. In March 2020, the Infectious Diseases Society America (IDSA) formed a multidisciplinary guideline panel...
Ceftazidime-avibactam is a novel cephalosporin-beta-lactamase inhibitor combination that active against many carbapenem-resistant Enterobacteriaceae (CRE). We describe retrospective chart review for 60 patients who received ceftazidime-avibactam CRE infection. In-hospital mortality was 32%, 53% of had microbiological cure, and 65% clinical success. In this severely ill population with infections, an appropriate option.
Abstract Background Multidrug-resistant Pseudomonas aeruginosa infections remain common in hospitals worldwide. We investigated the outcomes associated with use of ceftolozane-tazobactam for treatment these infections. Methods Data were collected retrospectively from 20 across United States about adults who received multidrug-resistant P any source at least 24 hours. The primary outcome was a composite 30-day and inpatient mortality, secondary clinical success microbiological cure....
Antimicrobials are commonly prescribed and often misunderstood. With more than 50% of hospitalized patients receiving an antimicrobial agent at any point in time, judicious optimal use these drugs is paramount to advancing patient care. This narrative will focus on myths relevant nuanced consultation from infectious diseases specialists, particularly surrounding specific considerations for a variety antibiotics.
Pharmacists are key partners in antimicrobial stewardship efforts, yet their degree of education on and attitudes toward this topic during training not well documented. An electronic survey measuring knowledge regarding use resistance was administered to graduating pharmacy students at 12 US schools pharmacy. Of 1445 students, 579 (40%) completed the survey. The vast majority (94%) believed that strong antimicrobials important for careers, 89% desired more appropriate use. Most (84%)...
We describe outcomes of patients with infections carbapenem-resistant Klebsiella pneumoniae (CRKP) who received ertapenem-containing double-carbapenem therapy (ECDCT). Clinical success was observed in 7/18 (39%) overall: bloodstream infections, 3/7 (43%); pneumonia, 1/5 (20%); intraabdominal 0/2 (0%); urinary tract 2/3 (67%); and a skin structure infection, 1/1 (100%). Microbiologic 11/14 (79%) evaluable patients; 5/18 (28%) died. ECDCT may be effective for CRKP limited treatment options.
ABSTRACT We studied the clinical and economic impact of a protocol encouraging use fidaxomicin as first-line drug for treatment Clostridium difficile infection (CDI) in patients hospitalized during 2-year period. This study evaluated who received oral vancomycin or CDI All included were eligible administration via that encouraged its selected patients. The primary endpoint was 90-day readmission with diagnosis CDI. Hospital charges insurance reimbursements readmissions calculated along cost...
When tetracyclines were introduced in the 1940s, these antibiotics offered a broad spectrum of activity against multiple types pathogens. However, their utility waned after selection tetracycline resistance pathogens which they effective. Omadacycline is semisynthetic aminomethylcycline antibacterial derived from class that unaffected by mechanisms. It has an appropriate for community-acquired infections, including those caused many resistant organisms. offers well-tolerated treatment acute...
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Based primarily on in vitro and animal models, with little data directly addressing patient outcomes, current guidelines recommend treating staphylococcal prosthetic valve endocarditis (PVE) antibiotic combinations including gentamicin rifampin. Here, we synthesize the clinical adjunctive rifampin PVE.We conducted a systematic review meta-analysis of PubMed- Cochrane-indexed studies reporting outcomes PVE treated rifampin, gentamicin, both agents, or neither (ie, glycopeptide β-lactam...
Abstract Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for treatment bacteremia or pneumonia due to MDR P. aeruginosa. We found that with resulted in higher rates clinical success compared after controlling baseline differences between cohorts. The objective this determine impact patient subgroups on overall findings. Methods patients were matched 1:1 within each site based severity illness, infection type, time initiation. primary...
Abstract Background ChatGPT is an artificial intelligence tool used by practitioners to answer clinical questions. It’s unknown whether provides quality responses infectious diseases (ID)-specific This study surveyed ID pharmacist subject matter experts (SMEs) assess the of responses. Methods The primary outcome was percentage considered useful. Secondary outcomes were SME’s ratings correctness, completeness, and safety (C/C/S). One hundred clinically encountered questions pharmacists...
Abstract Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for treatment bacteremia or pneumonia due to MDR P. aeruginosa. We previously demonstrated that with resulted in higher rates clinical success compared CZA. The objective this analysis compare day 30 Desirability Outcome Ranking (DOOR) between matched patient pairs. Methods patients were 1:1 within each site based on severity illness, infection type, time initiation. DOOR scale...