To determine whether there is an association between higher vancomycin trough concentrations and attainment of a calculated area under the concentration-time curve (AUC)/minimum inhibitory concentration (MIC) ≥400.A retrospective analysis was conducted among vancomycin-treated adult patients with positive methicillin-resistant Staphylococcus aureus (MRSA) culture. Attainment AUC/MIC ≥400 compared troughs in reference range 15 to 20 mg/L those following ranges: <10, 10 14.9, >20 mg/L....

Abstract Background Infectious Diseases Society of America guidelines recommend 14 days antifungal therapy for Candida urinary tract infections (UTIs). For bacterial UTIs, studies have demonstrated that shorter antibiotic durations comparable outcomes to longer durations. To our knowledge, there are no data compare (7 days) versus (14 UTI. Methods This was a single-center, retrospective cohort study between 1/1/15 and 1/1/24 at 752-bed academic medical center. Inclusion criteria were...

Abstract Background ChatGPT is an artificial intelligence tool used by practitioners to answer clinical questions. It’s unknown whether provides quality responses infectious diseases (ID)-specific This study surveyed ID pharmacist subject matter experts (SMEs) assess the of responses. Methods The primary outcome was percentage considered useful. Secondary outcomes were SME’s ratings correctness, completeness, and safety (C/C/S). One hundred clinically encountered questions pharmacists...

Limited evidence describes dalbavancin use in infective endocarditis (IE).A 27-year-old pregnant female received 4 weeks of for methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia and tricuspid valve IE after conventional therapy was no longer an option due to non-compliance. Despite having a smaller cardiac vegetation following dalbavancin, she bacteraemic <2 later with vancomycin-intermediate (VISA) telavancin-non-susceptible S. aureus.This is the first report unsuccessful...

Current international guidelines offer a conditional recommendation to consider single dose of IV desmopressin (DDAVP) for antiplatelet-associated intracranial hemorrhage based on low-quality evidence. We provide the first comparative assessment analyzing DDAVP effectiveness and safety in hemorrhage.Retrospective chart review.Single tertiary care academic medical center.Adult patients taking at least one antiplatelet agent presenting history documented evidence cerebral CT scan were...

Abstract Background It is unknown whether ChatGPT provides quality responses to infectious diseases (ID) pharmacotherapy questions. This study surveyed ID pharmacist subject matter experts (SMEs) assess the of version 3.5 (GPT-3.5) responses. Methods The primary outcome was percentage GPT-3.5 considered useful by SME rating. Secondary outcomes were SMEs' ratings correctness, completeness, and safety. Rating definitions based on literature review. One hundred questions entered into without...

Despite the numerous benefits of outpatient parenteral antimicrobial therapy (OPAT), appreciable risks drug-related problems (DRPs) exist. No studies to date comprehensively assess DRPs in this population.Objectives study were (1) characterize frequency and types experienced by patients discharged on OPAT (2) determine fraction adverse drug reactions (ADRs) resulting hospital readmission or emergency department (ED) presentation changes therapy.This was a retrospective chart analysis...

This study aimed to assess the impact of area under curve (AUC)-based vancomycin monitoring on pharmacist-initiated dose adjustments after transitioning from a trough-only an AUC-based method at our institution.A retrospective cohort patients treated with for complicated methicillin-resistant Staphylococcus aureus (MRSA) infection between November 2013 and December 2016 was conducted. The frequency assessed monitored via approaches trough ranges: 10 14.9 mg/L 15 20 mg/L.Fifty were included:...

Study Objective To compare rates of nephrotoxicity, time to nephrotoxicity onset, and clinical failure among patients who received continuous infusion (C‐I) or intermittent (I‐I) vancomycin in an outpatient parenteral antimicrobial therapy (OPAT) program. Nephrotoxicity was defined as increase serum creatinine greater than 0.5 mg/dl a 50% from baseline for two consecutive measurements while receiving during OPAT. Clinical unplanned readmission, extension therapy, change antibiotics. Design...

Background: Approximately 30% of antimicrobials prescribed in the outpatient setting are unnecessary and up to 50% inappropriate. Despite this, antimicrobial stewardship (AS) efforts mostly focus on inpatient setting, limited data describe AS interventions at hospital discharge. Acknowledging potential value discharge AS, we used our existing resources review oral prescriptions. Objective: The primary objective this retrospective, single-center study was evaluate impact an program Methods...

Background Published literature has demonstrated commercially available premix vancomycin (5 mg/mL) and piperacillin-tazobactam (67.5 as physically compatible via simulated Y-site methodology. Compatibility actual infusion yet to be established. Objective To assess compare the compatibility of concentrations evaluation. Methods Vancomycin were tested using methodologies. Simulated was performed previously published methods visual inspection, turbidity evaluation, pH Evaluation occurred...

Background Anti-Xa monitoring is utilized to measure the extent of anticoagulation in certain patient populations receiving enoxaparin. It essential accurately obtain this pharmacodynamic marker for safe and effective management. Objectives To determine frequency correctly drawn anti-Xa concentrations accordance with predefined institutional criteria number dose adjustments implemented based on incorrectly concentrations. Methods This was a retrospective, single-center, cohort study among...

There is limited information describing pharmacist participation in prophylactic enoxaparin monitoring the surgical intensive care unit (SICU).Our study sought to: 1) characterize recommendations for trauma patients admitted to SICU, 2) describe frequency that medical providers accept and 3) illustrate our SICU service achieve anti-factor Xa trough concentrations (AFXa-TRs) of 0.11 - 0.20 IU/mL following recommendation adjust dosing.Adult who had an AFXa-TR drawn after at least three...

Pharmacy-driven medication history (MH) programs have been shown to reduce the number of serious or potentially life-threatening (S/PLT) discrepancies (MDs) in many settings, but not Intensive Care Units (ICUs).MHs were repeated over a 6-week period. Demographics, number, and nature MDs documented. Discrepancy severity was graded using previously published method. Primary outcome proportion MHs containing >1 S/PLT MDs.Sixty-three repeated. Pharmacy less likely contain ≥1 (0% vs. 50%, P <...

Abstract Purpose We describe the structure, implementation, and initial evaluation of a formal residency research certificate program (RRCP) designed to further advance residents’ knowledge skills in an effort better prepare residents for involvement during their careers. Summary Pharmacy programs vary degree emphasis on education training structure resident activities. Limited data describing pharmacy are available. To educate process, State University New York Upstate Hospital developed...

Background: Compliance with guideline recommendations for surgical antibiotic prophylaxis (SAP) in colorectal surgery, particularly redosing, has been suboptimal at many institutions including ours. This study aimed to evaluate if single-dose ertapenem improves compliance SAP versus multiple-dose elective surgery. Methods: A retrospective, cohort of the use compared standard care agents was performed adult patients undergoing surgery an academic medical center between January 2020 and...